Hyaluronic acid conjugated polydopamine functionalized mesoporous silica nanoparticles for synergistic targeted chemo-photothermal therapy

Nanoscale ◽  
2019 ◽  
Vol 11 (22) ◽  
pp. 11012-11024 ◽  
Author(s):  
Chao Chen ◽  
Wen Tang ◽  
Dawei Jiang ◽  
Guoliang Yang ◽  
Xiaoli Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Photothermal Therapy ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
Site Specific ◽  
Functionalized Mesoporous Silica ◽  
Nano Drug Delivery ◽  
New Strategy ◽  
Surface Fabrication

This work reports a new strategy in surface fabrication of nano-drug delivery systems to achieve site-specific synergetic chemo-photothermal therapy.

scholarly journals Transporter-Targeted Nano-Sized Vehicles for Enhanced and Site-Specific Drug Delivery

Cancers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2837 ◽  
Author(s):  
Longfa Kou ◽  
Qing Yao ◽  
Hailin Zhang ◽  
Maoping Chu ◽  
Yangzom D. Bhutia ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Plasma Membrane ◽  
Blood Brain Barrier ◽  
Drug Delivery Systems ◽  
Cell Types ◽  
Delivery Systems ◽  
Target Cells ◽  
Specific Cell ◽  
Site Specific ◽  
Nano Drug Delivery

Nano-devices are recognized as increasingly attractive to deliver therapeutics to target cells. The specificity of this approach can be improved by modifying the surface of the delivery vehicles such that they are recognized by the target cells. In the past, cell-surface receptors were exploited for this purpose, but plasma membrane transporters also hold similar potential. Selective transporters are often highly expressed in biological barriers (e.g., intestinal barrier, blood–brain barrier, and blood–retinal barrier) in a site-specific manner, and play a key role in the vectorial transfer of nutrients. Similarly, selective transporters are also overexpressed in the plasma membrane of specific cell types under pathological states to meet the biological needs demanded by such conditions. Nano-drug delivery systems could be strategically modified to make them recognizable by these transporters to enhance the transfer of drugs across the biological barriers or to selectively expose specific cell types to therapeutic drugs. Here, we provide a comprehensive review and detailed evaluation of the recent advances in the field of transporter-targeted nano-drug delivery systems. We specifically focus on areas related to intestinal absorption, transfer across blood–brain barrier, tumor-cell selective targeting, ocular drug delivery, identification of the transporters appropriate for this purpose, and details of the rationale for the approach.

Recent Advances of Mesoporous Silica Based Multifunctional Nano Drug Delivery Systems

2013 ◽  
Vol 40 (10) ◽  
pp. 1014
Author(s):  
Xiao-Hong HAO ◽  
Cui-Miao ZHANG ◽  
Xiao-Long LIU ◽  
Xing-Jie LIANG ◽  
Guang JIA ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Recent Advances ◽  
Nano Drug Delivery

Recent Advances in Application of Azobenzenes Grafted on Mesoporous Silica Nanoparticles in Controlled Drug Delivery Systems Using Light as External Stimulus

2020 ◽  
Vol 20 (11) ◽  
pp. 1001-1016
Author(s):  
Sandra Ramírez-Rave ◽  
María Josefa Bernad-Bernad ◽  
Jesús Gracia-Mora ◽  
Anatoly K. Yatsimirsky
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
High Surface ◽  
Delivery Systems ◽  
Surface Reactivity ◽  
External Stimulus ◽  
Recent Advances

Hybrid materials based on Mesoporous Silica Nanoparticles (MSN) have attracted plentiful attention due to the versatility of their chemistry, and the field of Drug Delivery Systems (DDS) is not an exception. MSN present desirable biocompatibility, high surface area values, and a well-studied surface reactivity for tailoring a vast diversity of chemical moieties. Particularly important for DDS applications is the use of external stimuli for drug release. In this context, light is an exceptional alternative due to its high degree of spatiotemporal precision and non-invasive character, and a large number of promising DDS based on photoswitchable properties of azobenzenes have been recently reported. This review covers the recent advances in design of DDS using light as an external stimulus mostly based on literature published within last years with an emphasis on usually overlooked underlying chemistry, photophysical properties, and supramolecular complexation of azobenzenes.

Improving the Efficacy of Anticancer Drugs via Encapsulation and Acoustic Release

2018 ◽  
Vol 18 (10) ◽  
pp. 857-880 ◽  
Author(s):  
Salma E. Ahmed ◽  
Nahid Awad ◽  
Vinod Paul ◽  
Hesham G. Moussa ◽  
Ghaleb A. Husseini
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Special Focus ◽  
Nano Drug Delivery ◽  
Medical Researchers ◽  
History Of ◽  
Overall Performance ◽  
Enhanced Stability

Conventional chemotherapeutics lack the specificity and controllability, thus may poison healthy cells while attempting to kill cancerous ones. Newly developed nano-drug delivery systems have shown promise in delivering anti-tumor agents with enhanced stability, durability and overall performance; especially when used along with targeting and triggering techniques. This work traces back the history of chemotherapy, addressing the main challenges that have encouraged the medical researchers to seek a sanctuary in nanotechnological-based drug delivery systems that are grafted with appropriate targeting techniques and drug release mechanisms. A special focus will be directed to acoustically triggered liposomes encapsulating doxorubicin.

Current HPLC Methods for Assay of Nano Drug Delivery Systems

2017 ◽  
Vol 17 (13) ◽  
pp. 1588-1594 ◽  
Author(s):  
Serife Evrim Kepekci Tekkeli ◽  
Mustafa Volkan Kiziltas
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Nano Drug Delivery

Recent Advances in the Development of Polymeric Nanocarrier Formulations for the Treatment of Colon Cancer

2019 ◽  
Vol 9 (1) ◽  
pp. 2-14
Author(s):  
Sahil Kumar ◽  
Bandna Sharma ◽  
Kiran Thakur ◽  
Tilak R. Bhardwaj ◽  
Deo N. Prasad ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Colon Cancer ◽  
Hyaluronic Acid ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Near Ir ◽  
Targeted Drug ◽  
Poly Ethylene ◽  
Novel Drug

Background: Many efforts have been explored in the last decade to treat colon cancer but nanoparticulate drug delivery systems are making a vital contribution in the improvement of drug delivery to colon cancer cells. Objective: In this review, we attempt to highlight recent advancements in the development of novel drug delivery systems of nanoparticles for the targeted drug delivery to colon. Polymers like Epithelial Cell Adhesion Molecule (EpCAM) aptamer chitosan, Hyaluronic Acid (HA), Chitosan (CS)– Carboxymethyl Starch (CMS), silsesquioxane capped mesoporous silica, Near IR (NIR) fluorescent Human Serum Albumin (HAS), poly(ethylene glycol)-conjugated hyaluronic acid etc. have been discussed by employing various anticancer drugs like doxorubicin, oxaliplatin, paclitaxel, 5-fluorouracil etc. Conclusion: These novel drug delivery systems have been determined to be more efficacious in terms of stability, sustained and targeted drug delivery, therapeutic efficacy, improved bioavailability and enhanced anticancer activity.

New advances in brain-targeting nano-drug delivery systems for Alzheimer's disease

2021 ◽  
pp. 1-67
Author(s):  
Qin Ouyang ◽  
Yingcai Meng ◽  
Wenhu Zhou ◽  
Jianbin Tong ◽  
Zeneng Cheng ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Drug Delivery ◽  
Alzheimer's Disease ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Brain Targeting ◽  
Nano Drug Delivery
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