Visual detection of odorant geraniol enabled by integration of a human olfactory receptor into polydiacetylene/lipid nano-assembly

Nanoscale ◽  
2019 ◽  
Vol 11 (16) ◽  
pp. 7582-7587 ◽  
Author(s):  
Taegon Kim ◽  
Dongseok Moon ◽  
Jin Hyuk Park ◽  
Heehong Yang ◽  
Seongyeon Cho ◽  
...  
Keyword(s):  
Olfactory Receptor ◽  
Visual Detection ◽  
Specific Interaction ◽  
Odorant Detection

We fabricated a polydiacetylene lipid/human olfactory receptor nano-assembly for the “visualization of odorant detection” upon specific interaction with the target odorant, triggering a colorimetric transition and a distinctive fluorescence increase.

Odorant detection using liposome containing olfactory receptor in the SPR system

2014 ◽  
Vol 198 ◽  
pp. 188-193 ◽  
Author(s):  
Eun Hae Oh ◽  
Sang Hun Lee ◽  
Hwi Jin Ko ◽  
Tai Hyun Park
Keyword(s):  
Olfactory Receptor ◽  
Odorant Detection

Gas Phase Odorant Detection by Insect Olfactory Receptor

2021 ◽  
pp. 1-1
Author(s):  
Hongchao Deng ◽  
Hidefumi Mitsuno ◽  
Ryohei Kanzaki ◽  
Takamichi Nakamoto
Keyword(s):  
Gas Phase ◽  
Olfactory Receptor ◽  
Odorant Detection

Ultrastructural aspects of olfactory signal transduction and its development

1994 ◽  
Vol 52 ◽  
pp. 142-143
Author(s):  
Bert Ph. M. Menco
Keyword(s):  
Signal Transduction ◽  
Olfactory Receptor ◽  
Receptor Cell ◽  
Freeze Substitution ◽  
Luminal Surface ◽  
Tissue Sections ◽  
Olfactory Receptor Cells ◽  
Receptor Cells ◽  
Olfactory Signal ◽  
Odor Molecule

Vertebrate olfactory receptor cells are specialized neurons that have numerous long tapering cilia. The distal parts of these cilia line the interface between the external odorous environment and the luminal surface of the olfactory epithelium. The length and number of these cilia results in a large surface area that presumably increases the chance that an odor molecule will meet a receptor cell. Advanced methods of cryoprepration and immuno-gold labeling were particularly useful to preserve the delicate ultrastructural and immunocytochemical features of olfactory cilia required for localization of molecules involved in olfactory signal-transduction. We subjected olfactory tissues to freeze-substitution in acetone (unfixed tissues) or methanol (fixed tissues) followed by low temperature embedding in Lowicryl K11M for that purpose. Tissue sections were immunoreacted with several antibodies against proteins that are presumably important in olfactory signal-transduction.

Anxious anticipation prolongs emotional interference for rapid visual detection.

Emotion ◽  
2019 ◽  
Vol 19 (7) ◽  
pp. 1127-1137
Author(s):  
Nadia Haddara ◽  
Jonathan Ravid ◽  
Erica L. Miller ◽  
Molly O'Hagan ◽  
Chris Caracciolo ◽  
...  
Keyword(s):  
Visual Detection ◽  
Emotional Interference

Heparin Counteracts the Antiaggregating Effect of Prostacyclin by Potentiating Platelet Aggregation

1983 ◽  
Vol 49 (02) ◽  
pp. 081-083 ◽  
Author(s):  
Vittorio Bertelé ◽  
Maria Carla Roncaglioni ◽  
Maria Benedetta Donati ◽  
Giovanni de Gaetano
Keyword(s):  
Platelet Aggregation ◽  
Human Platelet ◽  
Specific Interaction ◽  
Inhibitory Effect ◽  
Effective Inhibitor ◽  
Inhibitory Potency ◽  
Human Platelet Aggregation

SummaryIt has recently been reported that heparin neutralizes the inhibitory effect of prostacyclin (PGI2) on human platelet aggregation. The mechanism of this interaction has not yet been unequivocally established. We present here evidence that heparin (Liquemin Roche) does not react directly with PGI2 but counteracts its inhibitory effect by potentiating platelet aggregation. In the absence of heparin, PGI2 was a less effective inhibitor of platelet aggregation induced by the combination of ADP and serotonin than by ADP alone. Moreover, the inhibitory effect of PGI2 was similarly reduced when increasing the concentrations of ADP (in the absence of heparin). The lack of a specific interaction between heparin and PGI2 is supported by the observation that, in the presence of heparin, other prostaglandins such as PGD2 and PGE1, and a non-prostanoid compound such as adenosine also appeared to lose their inhibitory potency. It is concluded that heparin opposes platelet aggregation inhibitory effect of PGI2 by enhancement of platelet aggregation.

Function of the olfactory receptor OR2AT4 in alveolar macrophages

2020 ◽  
Author(s):  
D Weidinger ◽  
D Alisch ◽  
K Jamal Jameel ◽  
M Ruhe ◽  
F Yusuf ◽  
...  
Keyword(s):  
Alveolar Macrophages ◽  
Olfactory Receptor
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