Click inspired synthesis of hexa and octadecavalent peripheral galactosylated glycodendrimers and their possible therapeutic applications

2019 ◽  
Vol 43 (31) ◽  
pp. 12475-12482 ◽  
Author(s):  
Anand K. Agrahari ◽  
Anoop S. Singh ◽  
Ashish Kumar Singh ◽  
Nidhi Mishra ◽  
Mala Singh ◽  
...  
Keyword(s):  
Therapeutic Potential ◽  
Therapeutic Applications

Click inspired glycodendrimers comprising a rigid hexapropargyloxy benzene core with peripheral β-d-galactopyranosidic units were developed and evaluated for their therapeutic potential.

scholarly journals Mesenchymal Stem Cell-Derived Extracellular Vesicle: A Promising Alternative Therapy for Osteoporosis

2021 ◽  
Vol 22 (23) ◽  
pp. 12750
Author(s):  
Cheng-Hsiu Lu ◽  
Yi-An Chen ◽  
Chien-Chih Ke ◽  
Ren-Shyan Liu
Keyword(s):  
Stem Cells ◽  
Therapeutic Potential ◽  
Large Population ◽  
Alternative Therapy ◽  
Osteoporosis Treatment ◽  
Extracellular Vesicle ◽  
Therapeutic Effects ◽  
Promising Alternative ◽  
Treatment Of Osteoporosis ◽  
Therapeutic Applications

Osteoporosis is the chronic metabolic bone disease caused by the disturbance of bone remodeling due to the imbalance of osteogenesis and osteoclastogenesis. A large population suffers from osteoporosis, and most of them are postmenopausal women or older people. To date, bisphosphonates are the main therapeutic agents in the treatment of osteoporosis. However, limited therapeutic effects with diverse side effects caused by bisphosphonates hindered the therapeutic applications and decreased the quality of life. Therefore, an alternative therapy for osteoporosis is still needed. Stem cells, especially mesenchymal stem cells, have been shown as a promising medication for numerous human diseases including many refractory diseases. Recently, researchers found that the extracellular vesicles derived from these stem cells possessed the similar therapeutic potential to that of parental cells. To date, a number of studies demonstrated the therapeutic applications of exogenous MSC-EVs for the treatment of osteoporosis. In this article, we reviewed the basic back ground of EVs, the cargo and therapeutic potential of MSC-EVs, and strategies of engineering of MSC-EVs for osteoporosis treatment.

scholarly journals Increased Mesenchymal Stem Cell Functionalization in Three-Dimensional Manufacturing Settings for Enhanced Therapeutic Applications

2021 ◽  
Vol 9 ◽  
Author(s):  
Dimitrios Kouroupis ◽  
Diego Correa
Keyword(s):  
Therapeutic Potential ◽  
Ex Vivo ◽  
Three Dimensional ◽  
Therapeutic Applications ◽  
Cell Based Therapy ◽  
Donor Variability ◽  
Healing Bone ◽  
Preclinical Animal Models

Mesenchymal stem/stromal cell (MSC) exist within their in vivo niches as part of heterogeneous cell populations, exhibiting variable stemness potential and supportive functionalities. Conventional extensive 2D in vitro MSC expansion, aimed at obtaining clinically relevant therapeutic cell numbers, results in detrimental effects on both cellular characteristics (e.g., phenotypic changes and senescence) and functions (e.g., differentiation capacity and immunomodulatory effects). These deleterious effects, added to the inherent inter-donor variability, negatively affect the standardization and reproducibility of MSC therapeutic potential. The resulting manufacturing challenges that drive the qualitative variability of MSC-based products is evident in various clinical trials where MSC therapeutic efficacy is moderate or, in some cases, totally insufficient. To circumvent these limitations, various in vitro/ex vivo techniques have been applied to manufacturing protocols to induce specific features, attributes, and functions in expanding cells. Exposure to inflammatory cues (cell priming) is one of them, however, with untoward effects such as transient expression of HLA-DR preventing allogeneic therapeutic schemes. MSC functionalization can be also achieved by in vitro 3D culturing techniques, in an effort to more closely recapitulate the in vivo MSC niche. The resulting spheroid structures provide spatial cell organization with increased cell–cell interactions, stable, or even enhanced phenotypic profiles, and increased trophic and immunomodulatory functionalities. In that context, MSC 3D spheroids have shown enhanced “medicinal signaling” activities and increased homing and survival capacities upon transplantation in vivo. Importantly, MSC spheroids have been applied in various preclinical animal models including wound healing, bone and osteochondral defects, and cardiovascular diseases showing safety and efficacy in vivo. Therefore, the incorporation of 3D MSC culturing approach into cell-based therapy would significantly impact the field, as more reproducible clinical outcomes may be achieved without requiring ex vivo stimulatory regimes. In the present review, we discuss the MSC functionalization in 3D settings and how this strategy can contribute to an improved MSC-based product for safer and more effective therapeutic applications.

Bridging Yoga Therapy and Personal Practice: The Power of Sadhana

2012 ◽  
Vol 22 (1) ◽  
pp. 89-90
Author(s):  
Ananda Balayogi Bhavanani
Keyword(s):  
Therapeutic Potential ◽  
Scientific Evidence ◽  
Yoga Therapy ◽  
Therapeutic Applications ◽  
Weakest Link ◽  
Conscious Living ◽  
Research Findings ◽  
Holistic Therapy

Yoga chikitsa (yoga as a holistic therapy) is becoming extremely popular, and numerous studies worldwide are providing scientific evidence of its therapeutic potential. 1-5 In our zest to make yoga popular, we may be missing the experiential link in the chain. The interconnectivity between research findings, their therapeutic applications, and the yoga therapist's practice must be strengthened to maintain the integrity of the practice of yoga. The strength of any chain is defined by its weakest link. Similarly, the healing potential of yoga chikitsa depends on the personal sadhana (practice) and conscious living of the therapist. We are the conduits, and we are responsible for transmitting the spirit of yoga to our patients or clients.

Therapeutic Potential of Equol: A Comprehensive Review

2020 ◽  
Vol 26 (45) ◽  
pp. 5837-5843
Author(s):  
Atiya Fatima ◽  
Mohd Shariq Khan ◽  
Md. Wasi Ahmad
Keyword(s):  
Estrogen Receptors ◽  
Human Health ◽  
Therapeutic Potential ◽  
Bacterial Flora ◽  
Parent Molecule ◽  
Comprehensive Review ◽  
Therapeutic Applications ◽  
High Affinity ◽  
Anti Cancer ◽  
Neuroprotective Efficacy

Equol (4',7-isoflavandiol), is a phytoestrogenic compound, which is synthesized from parent molecule diadzein by intestinal bacterial flora. It is among one of the most extensively researched molecule due to its high affinity towards estrogen receptors. Its enantiomeric form S-equol has been explored in the treatment of estrogen/androgen mediated diseases. Various therapeutic applications such as anti-cancer, cardioprotective, antidiabetic, antiosteoporosis, anti-ageing, and neuroprotective efficacy are attributed to it. This review explored major studies related to biochemistry and pharmacological applications of equol for human health.

scholarly journals A guide to maximizing the therapeutic potential of protein–polymer conjugates by rational design

2018 ◽  
Vol 47 (24) ◽  
pp. 8998-9014 ◽  
Author(s):  
Jeong Hoon Ko ◽  
Heather D. Maynard
Keyword(s):  
Rational Design ◽  
Therapeutic Potential ◽  
Careful Planning ◽  
Therapeutic Applications ◽  
Polymer Conjugates ◽  
Protein Polymer ◽  
Conjugation Chemistry ◽  
Polymer Conjugation ◽  
Selection Of

Careful planning in the selection of the protein, polymer, conjugation chemistry, and analysis can help maximize the potential of protein–polymer conjugates for therapeutic applications.

scholarly journals Triiodothyroacetic acid in health and disease

2017 ◽  
Vol 234 (2) ◽  
pp. R99-R121 ◽  
Author(s):  
Stefan Groeneweg ◽  
Robin P Peeters ◽  
Theo J Visser ◽  
W Edward Visser
Keyword(s):  
Thyroid Hormone ◽  
Transcriptional Activation ◽  
Therapeutic Potential ◽  
Transmembrane Transport ◽  
Ongoing Research ◽  
Therapeutic Applications ◽  
Physiological Relevance ◽  
Health And Disease ◽  
Mct8 Deficiency

Thyroid hormone (TH) is crucial for development and metabolism of many tissues. The physiological relevance and therapeutic potential of TH analogs have gained attention in the field for many years. In particular, the relevance and use of 3,3′,5-triiodothyroacetic acid (Triac, TA3) has been explored over the last decades. Although TA3 closely resembles the bioactive hormone T3, differences in transmembrane transport and receptor isoform-specific transcriptional activation potency exist. For these reasons, the application of TA3 as a treatment for resistance to TH (RTH) syndromes, especially MCT8 deficiency, is topic of ongoing research. This review is a summary of all currently available literature about the formation, metabolism, action and therapeutic applications of TA3.

scholarly journals Aza- and Azo-Stilbenes: Bio-Isosteric Analogs of Resveratrol

Molecules ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 605 ◽  
Author(s):  
Gérard Lizard ◽  
Norbert Latruffe ◽  
Dominique Vervandier-Fasseur
Keyword(s):  
Therapeutic Potential ◽  
Biological Activities ◽  
Research Groups ◽  
Aromatic Rings ◽  
Therapeutic Applications ◽  
Structure Activity Relationships ◽  
Natural Polyphenols ◽  
Structure Activity ◽  
Resveratrol Analogs ◽  
Resveratrol Derivatives

Several series of natural polyphenols are described for their biological and therapeutic potential. Natural stilbenoid polyphenols, such as trans-resveratrol, pterostilbene and piceatannol are well-known for their numerous biological activities. However, their moderate bio-availabilities, especially for trans-resveratrol, prompted numerous research groups to investigate innovative and relevant synthetic resveratrol derivatives. This review is focused on isosteric resveratrol analogs aza-stilbenes and azo-stilbenes in which the C=C bond between both aromatic rings was replaced with C=N or N=N bonds, respectively. In each series, synthetic ways will be displayed, and structural sights will be highlighted and compared with those of resveratrol. The biological activities of some of these molecules will be presented as well as their potential therapeutic applications. In some cases, structure-activity relationships will be discussed.

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