A nitro-capped tetraaniline derivative with AIE features for BSA detection and the selective imaging of Gram-positive bacteria

2019 ◽  
Vol 43 (30) ◽  
pp. 11816-11820 ◽  
Author(s):  
Beibei Liu ◽  
Kun Wang ◽  
Hao Lu ◽  
Mingming Huang ◽  
Jiping Yang
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Gram Positive ◽  
Gram Positive Bacteria ◽  
Turn On

A nitro-capped tetraaniline derivative (NO2-B3-Ani4-NO2) with AIE feature was synthesized and characterized, which presented an ultrasensitive turn-on response towards bovine serum albumin and selective imaging of Gram-positive bacteria based on AIE mechanism.

Deciphering the positional impact of chlorine in a new series of berberine analogues towards the superb-selective “turn-on” hydrophobic signaling of bovine serum albumin at physiological pH

2020 ◽  
Vol 44 (5) ◽  
pp. 1761-1771 ◽  
Author(s):  
Gopal Chandra Jana ◽  
Sk Nayim ◽  
Nandan Kumar Sahoo ◽  
Somnath Das ◽  
Mt Nasima Aktara ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Limit Of Detection ◽  
Selective Detection ◽  
Turn On

We report a new 9-O-benzyl substituted berberine analogue for the selective detection of BSA with a limit of detection value of 3.30 nM.

A fluorescence turn-on probe for human (bovine) serum albumin based on the hydrolysis of a dioxaborine group promoted by proteins

2017 ◽  
Vol 53 (48) ◽  
pp. 6432-6435 ◽  
Author(s):  
Qian Sun ◽  
Weisi Wang ◽  
Zhaoyang Chen ◽  
Yuhua Yao ◽  
Weibing Zhang ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
High Selectivity ◽  
Biologically Relevant ◽  
Turn On ◽  
Fluorescence Turn On ◽  
Hydrolysis Of

A reaction-based florescence probe CBF for serum albumin (SA) was proposed by connecting a dioxaborine unit with environment-sensitive coumarin fluorophore. CBF exhibits high selectivity and sensitivity toward SA over other biologically relevant species and has potential of detecting SA in biosamples.

Aggregation-Induced Emission Probes for Specific Turn-On Quantification of Bovine Serum Albumin

2020 ◽  
Vol 3 (8) ◽  
pp. 5193-5201
Author(s):  
Yuan Yu ◽  
Qing-Tian Gong ◽  
Wei-Fan Lu ◽  
Yan-Hong Liu ◽  
Zeng-Jie Yang ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Aggregation Induced Emission ◽  
Turn On

Merocyanine 540 adsorbed on polyethylenimine-functionalized graphene oxide nanocomposites as a turn-on fluorescent sensor for bovine serum albumin

2016 ◽  
Vol 18 (33) ◽  
pp. 23400-23406 ◽  
Author(s):  
Tuğba Bayraktutan ◽  
Kadem Meral
Keyword(s):  
Graphene Oxide ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Fluorescent Sensor ◽  
Functionalized Graphene ◽  
Functionalized Graphene Oxide ◽  
Turn On ◽  
Merocyanine 540

We suggest a simple, fast, sensitive and selective BSA sensor designed by assembling MC540 molecules on PEI–GO nanocomposites.

scholarly journals A Study of the Antibacterial Activities and the Mode of Action of L-Methionine and L-Cystine Based Surfactants and their Interaction with Bovine Serum Albumin Using Fluorescence Spectroscopy and in Silico Modelling

2021 ◽  
Vol 12 (6) ◽  
pp. 7356-7375
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Hydrophobic Interactions ◽  
Antibacterial Activities ◽  
Antimicrobial Activities ◽  
Resistant Bacteria ◽  
Binding Studies ◽  
Gram Positive ◽  
Gram Negative

Surfactants are versatile excipients that are commonly employed in diverse pharmaceutical formulations given their broad range of antimicrobial activities. Sulfur-based amino acid surfactants are promising candidates as substitutes for conventional antibacterial agents in light of the current antibiotic resistance crisis. Dodecyl esters of the free amine (SURF1), cationic ester hydrochloride (SURF2), and quaternary ammonium (QUAT3) derivatives of methionine, and the Gemini diester of cystine (GEM4) were synthesized and evaluated for antibacterial activity against Gram-positive and Gram-negative pathogens. All surfactants displayed moderate to high antibacterial activities, particularly on Gram-positive bacteria, with QUAT3 showing the highest activity. Among Gram-negative bacteria, QUAT3, GEM4, and SURF2 were mostly active towards K. pneumoniae with minimum inhibitory concentrations (MIC) ranging from 0.004 to 0.441 mM. QUAT3 and GEM4 displayed a bacteriostatic behavior similar to that of tetracycline, as assessed by broth macrodilution assays. Fluorescence binding studies with 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) revealed that the antibacterial activities could be attributed to a combination of electrostatic and hydrophobic interactions. Bovine serum albumin (BSA) fluorescence and molecular docking studies indicated that SURF1 and QUAT3 interact mainly via van der Waals' forces and hydrogen bonding while SURF2 binds through hydrophobic interactions. QUAT3, which displays broad-spectrum activity, has the potential to combat drug-resistant bacteria.

Sign in / Sign up

Export Citation Format

Share Document