Diosgenin-conjugated PCL–MPEG polymeric nanoparticles for the co-delivery of anticancer drugs: design, optimization, in vitro drug release and evaluation of anticancer activity

2019 ◽  
Vol 43 (17) ◽  
pp. 6622-6635 ◽  
Author(s):  
Sevinc Ilkar Erdagi ◽  
Ufuk Yildiz
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Anticancer Drugs ◽  
Polymeric Nanoparticles ◽  
Cancer Drug ◽  
In Vitro Drug Release ◽  
Polymeric Nanoparticle ◽  
Anti Cancer ◽  
Cancer Drug Delivery

In this study, a polymeric nanoparticle-mediated dual anti-cancer drug delivery system was designed and developed.

scholarly journals Fragmented polymer nanotubes from sonication-induced scission with a thermo-responsive gating system for anti-cancer drug delivery

2014 ◽  
Vol 2 (10) ◽  
pp. 1327-1334 ◽  
Author(s):  
Guofang Chen ◽  
Ruoyao Chen ◽  
Chunxiao Zou ◽  
Danwen Yang ◽  
Zhe-Sheng Chen
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Cancer Drug ◽  
Gating System ◽  
Anti Cancer ◽  
Grafting From ◽  
Cancer Drug Delivery ◽  
Polymer Nanotubes

Fragmented polymer nanotubes with a thermo-responsive gating system were prepared by a 2-fold “grafting-from” strategy and sonication-induced scission for efficient drug delivery. In vitro thermo-responsive DOX drug release and chemotoxicity were testified with such nanocarriers.

Characterization of Anti-Cancer Drug Materials Loaded Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) Microspheres for Drug Delivery System in Biochemical Material System

2012 ◽  
Vol 600 ◽  
pp. 137-143
Author(s):  
Jing Hui ◽  
Xiao Jie Yu ◽  
Yue Zhang ◽  
Feng Qing Hu
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Encapsulation Efficiency ◽  
In Vitro Release ◽  
Cancer Drug ◽  
Material System ◽  
Anti Cancer

Poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) is one of the components of polyhydroxyalkanoates (PHAs) and some of its mechanical properties have been shown to improve over poly (3-hydroxybutyrate) (PHB) and poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV). The investigation of PHBHHx microspheres as a drug delivery system was prepared by emulsion-solvent evaporation method for the sustained release of anti-cancer drug 5-fluorouracil (5-FU) and cyclosporin A (CsA). The mean diameter of the PHBHHx microspheres ranged from 5.24 to 22.10 μm dependent on the different processing parameters. The PHBHHx concentration, emulsifier concentration, anti-cancer drug dosage, and agitation speed, were optimized according to the encapsulation efficiency of 4% PHBHHx, 0.5% SDS, 10 mg anti-cancer drug, and 500 rpm. Under optimized conditions, the encapsulation efficiency of 5-FU and CsA microspheres were 7.19% and 96.44%, respectively. The morphologies of scanning electron microscope (SEM) suggested that PHBHHx microspheres were relatively smooth that provided better dispersion compared to PHB microspheres. The in vitro release profiles indicated 32.42% of 5-FU and 30.61% of CsA were released from PHBHHx microspheres during the initial burst phase, and the drug release from PHBHHx microsphere could be detected even after one month. The characteristics of PHBHHx microspheres demonstrated the feasibility of PHBHHx microsphere as a novel matrix for drug release system. With positive maintenance of the therapeutic concentrations of the drug, side effects can be reduced and patient compliance can be improved.

scholarly journals Recent Advances in the Cancer Drug Delivery: Nanocarrier Approach

2021 ◽  
Vol 69 (1) ◽  
Author(s):  
Deepak Prashar ◽  
Poonam Poonam
Keyword(s):  
Drug Delivery ◽  
Anticancer Drugs ◽  
Present Status ◽  
Present Review ◽  
Cancer Drug ◽  
Multiple Resistance ◽  
Poor Solubility ◽  
Anti Cancer ◽  
Cancer Drug Delivery ◽  
Tumor Drugs

The present review work tries to explore the present status of the nano carriers in the delivery of anti cancer drugs. The shortcomings associated with the anticancer drugs like poor solubility, multiple resistance and less bioavailability is been investigating using different nano formulations. The recent advance work on nanoparticles for the delivery of anti tumor drugs is focused along with the different patents available. The different technologies available in the present scenario for the delivery of anti-cancers drugs are being highlightened.

scholarly journals 3D Printed Calcium Phosphate Cement (CPC) Scaffolds for Anti-Cancer Drug Delivery

Pharmaceutics ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1077
Author(s):  
Yan Wu ◽  
Lisa Woodbine ◽  
Antony M. Carr ◽  
Amit R. Pillai ◽  
Ali Nokhodchi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Calcium Phosphate ◽  
Bone Graft ◽  
Bone Cancer ◽  
Cancer Drug ◽  
Anti Cancer ◽  
3D Printed ◽  
Polymeric Solutions ◽  
Cancer Drug Delivery

One of the main applications of bone graft materials is filling the gap after the surgical removal of bone cancer or tumors. Insufficient healing commonly leads to non-union fracture which could lead to cancer resurgence or infection. Emerging 3D printing of on-demand bone graft biomaterials can deliver personalized solutions with minimized risk of relapse and recurrence of cancer after bone removal surgery. This research aims to explore 3D printed calcium phosphate cement (CPC) based scaffolds as novel anti-cancer drug delivery systems to treat bone cancer. For the study, various 3D printed CPC based scaffolds (diameter 5 mm) with interconnected pores were utilized. Various optimized polymeric solutions containing a model anticancer drug 5-fluorouracil (5-FU) was used to homogenously coat the CPC scaffolds. Both hydrophilic Soluplus (SOL) and polyethylene glycol (PEG) and a combination of both were used to develop stable coating solutions. The surface morphology of the coated scaffolds, observed via SEM, revealed deposition of the polymeric solution represented by a semi-smooth surface as opposed to the blank scaffolds that showed a smoother surface. An advanced surface analysis conducted via confocal microscopy showed a homogenous distribution of the drug throughout the coated scaffolds. Solid-state analysis studied by applying differential scanning calorimetry (DSC) and X-ray diffraction (XRD) revealed semi-crystalline nature of the drug whereas mechanical analysis conducted via texture analysis showed no evidence in the change of the mechanical properties of the scaffolds after polymeric solutions were applied. The FTIR analysis revealed no major intermolecular interactions between 5-FU and the polymers used for coatings except for F2 where a potential nominal interaction was evidenced corresponding to higher Soluplus content in the formulation. In vitro dissolution studies showed that almost 100% of the drug released within 2 h for all scaffolds. Moreover, in vitro cell culture using two different cell lines (Hek293T-human kidney immortalized cell line and HeLa-human bone osteosarcoma epithelial cell line) showed significant inhibition of cell growth as a function of decreased numbers of cells after 5 days. It can be claimed that the developed 5-FU coated 3D printed scaffolds can successfully be used as bone graft materials to potentially treat bone cancer or bone neoplasm and for personalized medical solutions in the form of scaffolds for regenerative medicine or tissue engineering applications.

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