scholarly journals Sound-driven dissipative self-assembly of aromatic biomolecules into functional nanoparticles

2020 ◽  
Vol 5 (3) ◽  
pp. 553-563 ◽  
Author(s):  
Sukhvir Kaur Bhangu ◽  
Gianfranco Bocchinfuso ◽  
Muthupandian Ashokkumar ◽  
Francesca Cavalieri
Keyword(s):  
Amino Acid ◽  
Self Assembly ◽  
High Frequency ◽  
Aromatic Amino Acid ◽  
Biological Properties ◽  
Acoustic Energy ◽  
High Frequency Ultrasound ◽  
Functional Nanoparticles ◽  
Frequency Ultrasound

The out-of-equilibrium self-assembly of simple aromatic amino acid molecules is driven by high frequency ultrasound, where acoustic energy acts as a fuel to form uniform supramolecular nanostructures with multifarious optical and biological properties.

scholarly journals Sono-Assembly of the [Arg-Phe]4 Octapeptide into Biofunctional Nanoparticles

Nanomaterials ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 1772
Author(s):  
Anshul Baral ◽  
Sukhvir K. Bhangu ◽  
Rita Cimino ◽  
Juliane N. B. D. Pelin ◽  
Wendel A. Alves ◽  
...  
Keyword(s):  
Self Assembly ◽  
High Frequency ◽  
Colloidal Stability ◽  
Fluorescent Nanoparticles ◽  
High Frequency Ultrasound ◽  
One Pot ◽  
Combined Use ◽  
External Agents ◽  
Green Technique ◽  
Frequency Ultrasound

High-frequency ultrasound treatment is found to be a one-pot green technique to produce peptide-based nanostructures by ultrasound assisted self-assembly of oligopeptides. [Arg-Phe]4 octapeptides, consisting of alternating arginine (Arg/R) and phenylalanine (Phe/F) sequences, were subjected to 430 kHz ultrasound in aqueous solution in the absence of any external agents, to form [RF]4 nanoparticles ([RF]4-NPs), ~220 nm in diameter. A comprehensive analysis of the obtained nanoparticles demonstrated that the aromatic moieties of the oligopeptides can undergo oxidative coupling to form multiple oligomeric species, which then self-assemble into well-defined fluorescent nanoparticles. [RF]4-NPs were functionalized with polyethylene glycol (PEGylated) to improve their colloidal stability. Unlike the parent peptide, the PEGylated [RF]4-NPs showed limited cytotoxicity towards MDA-MB-231 cells. Furthermore, the intracellular trafficking of PEGylated [RF]4-NPs was investigated after incubation with MDA-MB-231 cells to demonstrate their efficient endo-lysosomal escape. This work highlights that the combined use of ultrasonic technologies and peptides enables easy fabrication of nanoparticles, with potential application in drug delivery.

Self-assembling behaviour of a modified aromatic amino acid in competitive medium

Soft Matter ◽  
2020 ◽  
Vol 16 (28) ◽  
pp. 6599-6607 ◽  
Author(s):  
Pijush Singh ◽  
Souvik Misra ◽  
Nayim Sepay ◽  
Sanjoy Mondal ◽  
Debes Ray ◽  
...  
Keyword(s):  
Amino Acid ◽  
Self Assembly ◽  
Aromatic Amino Acid ◽  
Photophysical Properties ◽  
Solvent Mixture ◽  
The Self ◽  
Solvent Ratio ◽  
Self Assembling

The self-assembly and photophysical properties of 4-nitrophenylalanine (4NP) are changed with the alteration of solvent and final self-assembly state of 4NP in competitive solvent mixture and are dictated by the solvent ratio.

scholarly journals Effectiveness of high frequency ultrasound on pressure ulcer

Medicine ◽  
2019 ◽  
Vol 98 (37) ◽  
pp. e17111 ◽  
Author(s):  
Xiang-qin Gao ◽  
Xiao-mei Xue ◽  
Jian-kang Zhang ◽  
Fei Yan ◽  
Qiu-xia Mu
Keyword(s):  
Pressure Ulcer ◽  
High Frequency ◽  
High Frequency Ultrasound ◽  
Frequency Ultrasound

Evaluation of frontal fibrosing alopecia with ultra‐high‐frequency ultrasound

2021 ◽  
Author(s):  
Carolina Ávila de Almeida ◽  
Simone Guarçoni ◽  
Bruna Duque Estrada ◽  
Maria Carolina Zafra Páez ◽  
Clarissa Canella
Keyword(s):  
High Frequency ◽  
High Frequency Ultrasound ◽  
Ultra High Frequency ◽  
Frequency Ultrasound
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