scholarly journals Anticancer drug delivery to cancer cells using alkyl amine-functionalized nanodiamond supraparticles

2019 ◽  
Vol 1 (9) ◽  
pp. 3406-3412 ◽  
Author(s):  
Yue Yu ◽  
Xi Yang ◽  
Ming Liu ◽  
Masahiro Nishikawa ◽  
Takahiro Tei ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery ◽  
Alkyl Amine ◽  
Amine Functionalized ◽  
Potential Applications

Nanocarriers have attracted increasing interest due to their potential applications in anticancer drug delivery.

scholarly journals AN ARTICLE REVIEW ON TUMOR-SPECIFIC AUTOMATED DRUG DELIVERY SYSTEM

2021 ◽  
Vol 9 (01) ◽  
pp. 1056-1057
Author(s):  
M. Lavanya ◽  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Tumor Cells ◽  
Drug Delivery System ◽  
Anticancer Drug ◽  
Delivery System ◽  
Anticancer Drug Delivery

In this article, targeted and controlled anticancer drug delivery and release with magneto-electric nanoparticles, published in 2016, rodzinski et al., explain how magneto-electric nanoparticles abbreviated as (mens) can be used to monitor the delivery of drugs and their release into cancer cells. They go further to explain how they use this automated drug delivery system to eradicate cancerous tumor cells.

Chitosan nanoparticles for lipophilic anticancer drug delivery: Development, characterization and in vitro studies on HT29 cancer cells

2016 ◽  
Vol 145 ◽  
pp. 362-372 ◽  
Author(s):  
Angela Abruzzo ◽  
Giampaolo Zuccheri ◽  
Federica Belluti ◽  
Simona Provenzano ◽  
Laura Verardi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Anticancer Drug ◽  
Chitosan Nanoparticles ◽  
In Vitro Studies ◽  
Anticancer Drug Delivery

Amphiphilic drug–drug assembly via dual-responsive linkages for small-molecule anticancer drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (71) ◽  
pp. 66420-66430 ◽  
Author(s):  
Tian Zhong ◽  
Ran Huang ◽  
Lianjiang Tan
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Anticancer Drug ◽  
Small Molecule ◽  
Disulfide Bonds ◽  
Anticancer Drug Delivery ◽  
Dual Responsive ◽  
Amphiphilic Drug

Amphiphilic drug–drug assembly nanoparticles based on dual-responsive H-bonding-instructed disulfide bonds can release irinotecan and doxorubicin simultaneously in cancer cells for anticancer purposes.

scholarly journals Doxorubicin–Gelatin/Fe3O4–Alginate Dual-Layer Magnetic Nanoparticles as Targeted Anticancer Drug Delivery Vehicles

Polymers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 1747
Author(s):  
Chiung-Hua Huang ◽  
Ting-Ju Chuang ◽  
Cherng-Jyh Ke ◽  
Chun-Hsu Yao
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Drug Release ◽  
Cancer Cells ◽  
Anticancer Drug ◽  
Magnetic Layer ◽  
Drug Delivery Vehicles ◽  
Anticancer Drug Delivery ◽  
Delivery Vehicles ◽  
Mcf 7

In this study, magnetic nanoparticles composed of a core (doxorubicin–gelatin) and a shell layer (Fe3O4–alginate) were developed to function as targeted anticancer drug delivery vehicles. The anticancer drug doxorubicin (DOX) was selected as a model drug and embedded in the inner gelatin core to obtain high encapsulation efficiency. The advantage of the outer magnetic layer is that it targets the drug to the tumor tissue and provides controlled drug release. The physicochemical properties of doxorubicin–gelatin/Fe3O4–alginate nanoparticles (DG/FA NPs) were characterized using scanning electron microscopy, Fourier transform infrared spectroscopy (FTIR), and X-ray diffraction. The mean diameter of DG/FA NPs, which was determined using a zeta potential analyzer, was 401.8 ± 3.6 nm. The encapsulation rate was 64.6 ± 11.8%. In vitro drug release and accumulation were also studied. It was found that the release of DOX accelerated in an acidic condition. With the manipulation of an external magnetic field, DG/FA NPs efficiently targeted Michigan Cancer Foundation-7 (MCF-7) breast cancer cells and showed in the nucleus after 6 h of incubation. After 12 h of incubation, the relative fluorescence intensity reached 98.4%, and the cell viability of MCF-7 cells decreased to 52.3 ± 4.64%. Dual-layer DG/FA NPs could efficiently encapsulate and deliver DOX into MCF-7 cells to cause the death of cancer cells. The results show that DG/FA NPs have the potential for use in targeted drug delivery and cancer therapy.

scholarly journals FRET-based intracellular investigation of nanoprodrugs toward highly efficient anticancer drug delivery

Nanoscale ◽  
2020 ◽  
Vol 12 (32) ◽  
pp. 16710-16715
Author(s):  
Farsai Taemaitree ◽  
Beatrice Fortuni ◽  
Yoshitaka Koseki ◽  
Eduard Fron ◽  
Susana Rocha ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery ◽  
Highly Efficient ◽  
Intracellular Investigation

FRET Nanoprodrugs (FRET-NPDs) were synthesized and internalized in cancer cells to study their intracellular dynamics and degradation.

Biocompatible magnetic tris(2-aminoethyl)amine functionalized nanocrystalline cellulose as a novel nanocarrier for anticancer drug delivery of methotrexate

2017 ◽  
Vol 41 (5) ◽  
pp. 2160-2168 ◽  
Author(s):  
Mahdi Rahimi ◽  
Salman Shojaei ◽  
Kazem D. Safa ◽  
Zarrin Ghasemi ◽  
Roya Salehi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Anticancer Drug ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Ph Responsive ◽  
Anticancer Drug Delivery ◽  
Amine Functionalized ◽  
Targeted Drug ◽  
Targeted Drug Delivery System

A smart, pH-responsive and biocompatible nanocarrier, aimed to achieve an efficient targeted drug delivery system, was facilely synthesized.

RNA aptamer-conjugated liposome as an efficient anticancer drug delivery vehicle targeting cancer cells in vivo

2014 ◽  
Vol 196 ◽  
pp. 234-242 ◽  
Author(s):  
Si Eun Baek ◽  
Kwang Hyun Lee ◽  
Yong Serk Park ◽  
Deok-Kun Oh ◽  
Sangtaek Oh ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Anticancer Drug ◽  
Rna Aptamer ◽  
Delivery Vehicle ◽  
Drug Delivery Vehicle ◽  
Anticancer Drug Delivery

ARGININE- AND ACRYLONITRILE-MODIFIED CHITOSAN NANOPARTICLES FOR ANTICANCER DRUG DELIVERY

NANO ◽  
2014 ◽  
Vol 09 (07) ◽  
pp. 1450075 ◽  
Author(s):  
LIANCHENG YIN ◽  
TING SU ◽  
JING CHANG ◽  
RONG LIU ◽  
BIN HE ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Anticancer Drug ◽  
Laser Scanning ◽  
Drug Loading ◽  
Chitosan Nanoparticles ◽  
Laser Scanning Microscopy ◽  
Confocal Laser ◽  
Anticancer Drug Delivery ◽  
Modified Chitosan

Chitosan (CS) is an excellent natural biodegradable and biocompatible polymer for biomedical applications, however, its poor solubility in water or organic solvents limits its applications in drug delivery. In order to resolve this problem, chitosan was modified with acrylonitrile (AN) and arginine (Arg), the modified chitosan (AN–CS–Arg) was characterized by 1 H NMR and Fourier transform infrared (FTIR). The AN–CS–Arg was self-assembled into nanoparticles to encapsulate anticancer drug doxorubicin (DOX). The size and morphology of the blank and drug-loaded AN–CS–Arg (AN–CS–Arg/DOX) nanoparticles were measured by dynamic light scattering (DLS), scanning electron microscopy (SEM) and atomic force microscopy (AFM). The mean size of both blank and AN–CS–Arg/DOX nanoparticles were around 50 nm and 170 nm, respectively. The drug-loading content was about 12%. The release profile of AN–CS–Arg/DOX nanoparticles was investigated in vitro, 80% encapsulated DOX could be released within 80 h. The AN–CS–Arg nanoparticles were nontoxic to both NIH 3T3 fibroblasts and HepG2 cancer cells. The cellular uptake of the AN–CS–Arg nanoparticles was trafficked via Confocal Laser Scanning Microscopy and Flow Cytometry, both results showed that the AN–CS–Arg nanoparticles could be internalized in HepG2 cells efficiently. The IC50 of AN–CS–Arg/DOX nanoparticles to HepG2 cancer cells was 10.0 μg/mL. The AN–CS–Arg nanoparticles are potential carriers for anticancer drug delivery.

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