Lanthanum chloride impairs spatial learning and memory by inducing [Ca2+]m overload, mitochondrial fission–fusion disorder and excessive mitophagy in hippocampal nerve cells of rats

Metallomics ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 592-606 ◽  
Author(s):  
Miao Yu ◽  
Jinghua Yang ◽  
Xiang Gao ◽  
Wenchang Sun ◽  
Shiyu Liu ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Mitochondrial Fission ◽  
Nerve Cells ◽  
Lanthanum Chloride ◽  
Spatial Learning And Memory

Lanthanum chloride damages hippocampal nerve cells of rats through inducing [Ca2+]m overload, mitochondrial fission–fusion disorder, and excessive mitophagy.

Lanthanum chloride impairs spatial learning and memory and downregulates NF-κB signalling pathway in rats

2013 ◽  
Vol 87 (12) ◽  
pp. 2105-2117 ◽  
Author(s):  
Linlin Zheng ◽  
Jinghua Yang ◽  
Qiufang Liu ◽  
Fei Yu ◽  
Shengwen Wu ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Signalling Pathway ◽  
Lanthanum Chloride ◽  
Spatial Learning And Memory

scholarly journals GABAB receptor antagonist promotes hippocampal neurogenesis and facilitates cognitive function recovery following acute cerebral ischemia in mice

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Dan Song ◽  
Yaohua Chen ◽  
Cheng Chen ◽  
Lili Chen ◽  
Oumei Cheng
Keyword(s):  
Cognitive Function ◽  
Cerebral Ischemia ◽  
Learning And Memory ◽  
Spatial Learning ◽  
Hippocampal Neurogenesis ◽  
Morris Water Maze Test ◽  
Spatial Learning And Memory ◽  
In Vitro Experiments ◽  
Adult Mice

Abstract Purpose and background Previous studies have suggested that promoting endogenous neurogenesis has great significance for the recovery of cognitive dysfunction caused by cerebral ischemia (CI). Pharmacological inhibition of GABAB receptor can enhance neurogenesis in adult healthy and depressed mice. In the study, we intended to investigate the effects of GABAB receptor antagonists on cognitive function and hippocampal neurogenesis in mice following CI. Methods Adult mice were subjected to bilateral common carotid artery occlusion (BCCAO) for 20 min to induce CI and treated with CGP52432 (antagonist of GABAB receptor, CGP, 10 mg/kg intraperitoneal injection) starting 24 h after CI. The Morris water maze test was performed to test spatial learning and memory at day 28. Immunofluorescence was applied to detect neurogenesis in the DG region at day 14 and 28. In in vitro experiments, cell proliferation was detected by CCK8 and immunofluorescence, and the expression of cAMP/CREB signaling pathway-related proteins was detected by ELISA assay and Western blot. Results CGP significantly improved spatial learning and memory disorders caused by CI, and it enhanced the proliferation of neural stem cells (NSCs), the number of immature neurons, and the differentiation from newborn cells to neurons. In vitro experiments further confirmed that CGP dose-dependently enhanced the cell viability of NSCs, and immunofluorescence staining showed that CGP promoted the proliferation of NSCs. In addition, treatment with CGP increased the expression of cAMP, PKA, and pCREB in cultured NSCs. Conclusion Inhibition of GABAB receptor can effectively promote hippocampal neurogenesis and improve spatial learning and memory in adult mice following CI.

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