Chiral Ru(ii) complexes act as a potential non-viral gene carrier for directional transportation to the nucleus and cytoplasm

Metallomics ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 504-513
Author(s):  
Qiong Wu ◽  
Shuang-Yan Zhang ◽  
Si-Yan Liao ◽  
Jie-Qiong Cao ◽  
Wen-Jie Zheng ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Self Assembly ◽  
The Self ◽  
Gene Carrier ◽  
Viral Gene ◽  
Carrier System ◽  
Quadruplex Dna ◽  
Novel Approach ◽  
G Quadruplex

A novel approach has been proposed to develop a potent gene carrier system for enantioselectivity on the self-assembly of G-quadruplex DNA promoted by chiral Ru(ii) complexes, and the different assembled nanostructures of cellular uptake to the nucleus and cytoplasm.

Lab in a tube: a fast-assembled colorimetric sensor for highly sensitive detection of oligonucleotides based on a hybridization chain reaction

RSC Advances ◽  
2015 ◽  
Vol 5 (55) ◽  
pp. 44714-44721 ◽  
Author(s):  
Siqi Zhang ◽  
Kun Wang ◽  
Zhenyu Li ◽  
Zhongmin Feng ◽  
Ting Sun
Keyword(s):  
Complex Formation ◽  
Dna Sequence ◽  
Self Assembly ◽  
The Self ◽  
Hybridization Chain Reaction ◽  
Chain Reaction ◽  
Highly Sensitive ◽  
G Quadruplex ◽  
Colored Product ◽  
Highly Sensitive Detection

Upon adding THBV, the self-assembly of THBV with H1 allows the rest of the DNA sequence of H1 to accelerate H1–H2 complex formation. The G-quadruplex at the end of the H1–H2 complex could catalyze TMB into a colored product.

scholarly journals A Ruthenium(ii) complex as a potential luminescent switch-on probe for G-quadruplex DNA

RSC Advances ◽  
2017 ◽  
Vol 7 (38) ◽  
pp. 23727-23734 ◽  
Author(s):  
Li Li ◽  
Hui-Min Liu ◽  
Xu-Kui Liu ◽  
Si-Yan Liao ◽  
Yu-Tao Lan ◽  
...  
Keyword(s):  
Self Assembly ◽  
Quadruplex Dna ◽  
G Quadruplex

A ruthenium(ii) complex can be developed as a potential luminescence switch-on probe through selectively recognizing and promoting self-assembly of c-myc G-quadruplex DNA.

Polymeric Janus nanoparticles templated by block copolymer thin films

RSC Advances ◽  
2015 ◽  
Vol 5 (55) ◽  
pp. 44218-44221 ◽  
Author(s):  
Elio Poggi ◽  
Jean-Pierre Bourgeois ◽  
Bruno Ernould ◽  
Jean-François Gohy
Keyword(s):  
Thin Films ◽  
Surface Modification ◽  
Block Copolymer ◽  
Block Copolymers ◽  
Self Assembly ◽  
The Self ◽  
Polymer Grafting ◽  
Novel Approach ◽  
Janus Nanoparticles

We report a novel approach to synthesize well-defined polymeric Janus nanoparticles by combining the self-assembly of block copolymers in thin films and surface modification by polymer grafting.

Synthesis and aggregation properties of boron-dipyrromethene dyes conjugated with guanine units

2018 ◽  
Vol 22 (09n10) ◽  
pp. 944-952 ◽  
Author(s):  
Fen Li ◽  
Yongjie Zhang ◽  
Lina Zhou ◽  
Xin Zhang ◽  
Zhijian Chen
Keyword(s):  
Self Assembly ◽  
Solvent Polarity ◽  
The Self ◽  
X Ray ◽  
X Ray Crystallography ◽  
H Nmr ◽  
Nmr Study ◽  
Vis Spectroscopy ◽  
G Quadruplex ◽  
Boron Dipyrromethene

Two boron-dipyrromethene dyes bearing a conjugated guanine unit (G-BODIPYs) 1 and 2 were synthesized and fully characterized. The self-assembly properties of these dyes were investigated by X-ray crystallography, [Formula: see text]H NMR and UV-vis spectroscopy. As revealed by X-ray crystal structure studies, G-BODIPY 1 self-assembled into ribbon-like structures due to the intermolecular hydrogen bonding and [Formula: see text]–[Formula: see text] stacking interaction. Concentration-dependent [Formula: see text]H NMR experiments confirmed the formation of hydrogen bonds of the guanine units in solution for both dye 1 and 2. In the presence of K[Formula: see text], the characteristic signals for the formation of cyclic G-quadruplex structures were observed in the [Formula: see text]H NMR study. Aggregation of G-BODIPY dyes was further monitored by UV-vis absorption spectroscopy by varying the solvent polarity and temperature. H-type aggregates of dye 1, which was characterized by a new hypsochromically shifted absorption band with [Formula: see text] 461 nm, was obtained. In the presence of K[Formula: see text], the enhancement of stability was observed for the H-aggregates of dye 1.

Self-assembly of isomannide-based monoesters of C18-fatty acids and their cellular uptake studies

RSC Advances ◽  
2016 ◽  
Vol 6 (76) ◽  
pp. 72074-72079 ◽  
Author(s):  
Prabhu Dhasaiyan ◽  
Nimisha Parekh ◽  
T. Vijai Kumar Reddy ◽  
G. Sandhya Rani ◽  
B. L. A. Prabhavathi Devi ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Stearic Acid ◽  
Cellular Uptake ◽  
Self Assembly ◽  
The Self ◽  
Self Assembling ◽  
Uptake Studies

The self-assembling behavior of oleic, elaidic and stearic acid-isomannide glycolipids is revealed.

scholarly journals Chiral Ruthenium(II) Polypyridyl Complexes: Stabilization of G-Quadruplex DNA, Inhibition of Telomerase Activity and Cellular Uptake

PLoS ONE ◽  
2012 ◽  
Vol 7 (12) ◽  
pp. e50902 ◽  
Author(s):  
Qianqian Yu ◽  
Yanan Liu ◽  
Chuan Wang ◽  
Dongdong Sun ◽  
Xingcheng Yang ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Telomerase Activity ◽  
Polypyridyl Complexes ◽  
Quadruplex Dna ◽  
G Quadruplex ◽  
Dna Inhibition

A lipophilic “fully-anti” dodecamer from a (5′S)-5′,8-cyclo-2′-deoxyguanosine

2014 ◽  
Vol 50 (73) ◽  
pp. 10722-10725 ◽  
Author(s):  
Silvia Pieraccini ◽  
Michael A. Terzidis ◽  
Enrico J. Baldassarri ◽  
Giovanna Fragneto ◽  
Paolo Mariani ◽  
...  
Keyword(s):  
Self Assembly ◽  
The Self ◽  
G Quadruplex ◽  
Lipophilic Derivative

The self-assembly of a lipophilic derivative of mutagenic (5′S)-5′,8-cyclo-2′-deoxyguanosine has been investigated by CD, NMR and SANS. The derivative forms a dodecameric G-quadruplex composed of three stacked fully-anti G-quartets.

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