Anticancer auranofin engages 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) as a target

Metallomics ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 1925-1936 ◽  
Author(s):  
Songhai Tian ◽  
Fung-Ming Siu ◽  
Chun-Nam Lok ◽  
Yi Man Eva Fung ◽  
Chi-Ming Che
Keyword(s):  
Mechanism Of Action ◽  
Coenzyme A ◽  
Subcellular Fractionation ◽  
Proteomics Analysis ◽  
Anticancer Mechanism ◽  
Fractionation Method ◽  
Novel Target ◽  
Coenzyme A Reductase

Subcellular fractionation method was used with HPLC-MS/MS technique for proteomics analysis to study the anticancer mechanism of action of auranofin. HMGCR is identified as a novel target of auranofin.

scholarly journals Mechanism of Action of a 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor on Apolipoprotein B-100 Kinetics in Visceral Obesity

2002 ◽  
Vol 87 (5) ◽  
pp. 2283-2289 ◽  
Author(s):  
Dick C. Chan ◽  
Gerald F. Watts ◽  
P. Hugh R. Barrett ◽  
Trevor A. Mori ◽  
Lawrence J. Beilin ◽  
...  
Keyword(s):  
Mechanism Of Action ◽  
Apolipoprotein B ◽  
Reductase Inhibitor ◽  
Coenzyme A ◽  
Visceral Obesity ◽  
Coenzyme A Reductase

pH Properties and chemical mechanism of action of 3-hydroxy-3-methylglutaryl coenzyme A reductase

Biochemistry ◽  
1981 ◽  
Vol 20 (4) ◽  
pp. 887-894 ◽  
Author(s):  
Dulce Veloso ◽  
W. W. Cleland ◽  
John W. Porter
Keyword(s):  
Mechanism Of Action ◽  
Coenzyme A ◽  
Chemical Mechanism ◽  
Coenzyme A Reductase

Immunotropic Effects and Proposed Mechanism of Action for 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Inhibitors (Statins)

2018 ◽  
Vol 83 (8) ◽  
pp. 874-889 ◽  
Author(s):  
T. I. Arefieva ◽  
A. Yu. Filatova ◽  
A. V. Potekhina ◽  
A. M. Shchinova
Keyword(s):  
Mechanism Of Action ◽  
Coenzyme A ◽  
Reductase Inhibitors ◽  
Coenzyme A Reductase

Simvastatin, an HMG–Coenzyme A Reductase Inhibitor, Improves Endothelial Function Within 1 Month

Circulation ◽  
1997 ◽  
Vol 95 (5) ◽  
pp. 1126-1131 ◽  
Author(s):  
Gerard O'Driscoll ◽  
Danny Green ◽  
Roger R. Taylor
Keyword(s):  
Endothelial Function ◽  
Reductase Inhibitor ◽  
Coenzyme A ◽  
Coenzyme A Reductase
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