Is protein context responsible for peptide-mediated interactions?

2019 ◽  
Vol 15 (4) ◽  
pp. 280-295 ◽  
Author(s):  
Peng Zhou ◽  
Qingqing Miao ◽  
Fugang Yan ◽  
Zhongyan Li ◽  
Qianhu Jiang ◽  
...  
Keyword(s):  
Cell Signaling ◽  
Signaling Pathways ◽  
The Stability ◽  
Cell Signaling Pathways

Many cell signaling pathways are orchestrated by the weak, transient, and reversible peptide-mediated interactions (PMIs). Here, the role of protein context in contributing to the stability and specificity of PMIs is investigated systematically.

Scaffold Proteins and their Roles in Human Diseases

2020 ◽  
Vol 14 (01) ◽  
pp. 15-29
Author(s):  
Somsubhro Mukherjee ◽  
Boon Chuan Low
Keyword(s):  
Cell Signaling ◽  
Signaling Pathways ◽  
Drug Targets ◽  
Metabolic Diseases ◽  
Scaffold Proteins ◽  
Human Diseases ◽  
Normal Functions ◽  
Cellular Pathways ◽  
Cell Signaling Pathways

Scaffold proteins are critical regulators of important cell signaling pathways. Though scaffolds are not stringently defined in meaning, they are known to interact with numerous components of a signaling pathway, binding and bridging them into distinct and functional complexes. They control signal transduction and assist the localization of pathway components (organized in complexes) to definite regions of the cell such as the endosomes, plasma membrane, the cytoplasm, mitochondria, Golgi, and the nucleus. Years of research in this field have revealed the versatility of this class of protein and the important role it plays in maintaining the normal functions of the human body. Here, we discuss the role of several scaffold proteins which are implicated in important signaling pathways that play important roles in cardiac diseases, metabolic diseases, neurological disorders, and cancer. Their versatility and functions in human diseases make them attractive drug targets, several of which have been investigated in clinical trials. Future studies of scaffold proteins should give us an in-depth knowledge of how cell signaling works in normal and pathological conditions and would offer avenues to disrupt harmful cellular pathways to circumvent diseases.

The role of melatonin in targeting cell signaling pathways in neurodegeneration

2019 ◽  
Vol 1443 (1) ◽  
pp. 75-96 ◽  
Author(s):  
Mayuri Shukla ◽  
Vorapin Chinchalongporn ◽  
Piyarat Govitrapong ◽  
Russel J. Reiter
Keyword(s):  
Cell Signaling ◽  
Signaling Pathways ◽  
Cell Signaling Pathways

T2065 Curcumin Suppresses Intestinal Epithelial Response to Clostridium difficile Infection: Role of Cell Signaling Pathways

2009 ◽  
Vol 136 (5) ◽  
pp. A-631
Author(s):  
Nandakumar Srinivasan ◽  
Dharmalingam Subramaniam ◽  
Aarthi Varman ◽  
Rama P. Ramanujam ◽  
Courtney W. Houchen ◽  
...  
Keyword(s):  
Clostridium Difficile ◽  
Cell Signaling ◽  
Signaling Pathways ◽  
Clostridium Difficile Infection ◽  
Intestinal Epithelial ◽  
Cell Signaling Pathways

scholarly journals Glycogen Synthase Kinase-3 Is Required for EfficientDictyosteliumChemotaxis

2010 ◽  
Vol 21 (15) ◽  
pp. 2788-2796 ◽  
Author(s):  
Regina Teo ◽  
Kimberley J. Lewis ◽  
Josephine E. Forde ◽  
W. Jonathan Ryves ◽  
Jonathan V. Reddy ◽  
...  
Keyword(s):  
Cell Signaling ◽  
Signaling Pathways ◽  
Cell Fate ◽  
Glycogen Synthase ◽  
Cell Aggregation ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3 ◽  
Cell Fate Determination ◽  
Cell Signaling Pathways

Glycogen synthase kinase-3 (GSK3) is a highly conserved protein kinase that is involved in several important cell signaling pathways and is associated with a range of medical conditions. Previous studies indicated a major role of the Dictyostelium homologue of GSK3 (gskA) in cell fate determination during morphogenesis of the fruiting body; however, transcriptomic and proteomic studies have suggested that GSK3 regulates gene expression much earlier during Dictyostelium development. To investigate a potential earlier role of GskA, we examined the effects of loss of gskA on cell aggregation. We find that cells lacking gskA exhibit poor chemotaxis toward cAMP and folate. Mutants fail to activate two important regulatory signaling pathways, mediated by phosphatidylinositol 3,4,5-trisphosphate (PIP3) and target of rapamycin complex 2 (TORC2), which in combination are required for chemotaxis and cAMP signaling. These results indicate that GskA is required during early stages of Dictyostelium development, in which it is necessary for both chemotaxis and cell signaling.

scholarly journals Role of non-coding RNAs as novel biomarkers for detection of colorectal cancer progression through interaction with the cell signaling pathways

Gene ◽  
2020 ◽  
Vol 753 ◽  
pp. 144796 ◽  
Author(s):  
Mohadeseh Esmaeili ◽  
Maryam Keshani ◽  
Mehrdad Vakilian ◽  
Maryam Esmaeili ◽  
Maryam Peymani ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Signaling ◽  
Signaling Pathways ◽  
Cancer Progression ◽  
Novel Biomarkers ◽  
Non Coding Rnas ◽  
Colorectal Cancer Progression ◽  
Cell Signaling Pathways

scholarly journals A Novel Prognostic Biomarker ARRDC2 has Potential to Define Tumor Microenvironment in Ovarian Cancer

2021 ◽  
Author(s):  
Mengjun Zhang ◽  
Yunduo Liu ◽  
Yuan Liu ◽  
Siyu Hou ◽  
Hao Li ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cell Signaling ◽  
Signaling Pathways ◽  
Immune Microenvironment ◽  
Poor Overall Survival ◽  
Protein Levels ◽  
Diagnosis And Prognosis ◽  
Tumor Immune Microenvironment ◽  
Cell Signaling Pathways

Abstract Purpose: The abnormal expression of α-arrestin protein family plays a key regulatory role in the occurrence and development of many cancers, including colorectal cancer and cervical cancer, and is inseparable from changes in the tumor immune microenvironment. However, the role of ARRDC2, an important member of this family, in the malignant biological process of ovarian cancer (OC) has not been reported, and its role in the change of the immune microenvironment is also unknown.Methods: In this study, HPA, TCGA, GEO and other databases were used to explore the role of ARRDC2 in the diagnosis and prognosis assessment of ovarian cancer. Then, GO, KEGG analysis and GSEA analysis of the biological processes and cell signaling pathways that ARRDC2 may be involved in activated or inhibited. In addition, the TIMER and TISIDB database were used to conduct in-depth research on the role of ARRDC2 in the change of the immune microenvironment of ovarian cancer. Finally, the CMAP database explored and screened drugs that may be used for treatment.Results: There were significant differences between OC and ARRDC2 mRNA and protein levels. High ARRDC2 expression level is associated with poor overall survival and can be used as an independent prognostic factor. Interestingly, ARRDC2 expression is positively correlated with B cells, Neutrophils, Dendritic cells and CD8+ T cells, signifying that ARRDC2 may be related to infiltration of immune cells. ARRDC2 and its co-expressed genes are enriched in cell signaling pathways related to the immune system. Finally, we explored two possible drugs for the treatment of ovarian cancer.Conclusion: The differentially expressed ARRDC2 may be a potential prognostic and diagnostic indicator and can be used as a novel biomarker for exploring the immune microenvironment of ovarian cancer.

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