scholarly journals Argininamide-type neuropeptide Y Y1 receptor antagonists: the nature of Nω-carbamoyl substituents determines Y1R binding mode and affinity

2020 ◽  
Vol 11 (2) ◽  
pp. 274-282
Author(s):  
Jonas Buschmann ◽  
Theresa Seiler ◽  
Günther Bernhardt ◽  
Max Keller ◽  
David Wifling
Keyword(s):  
Neuropeptide Y ◽  
Binding Mode ◽  
Reference Compound ◽  
Induced Fit Docking ◽  
Receptor Antagonists ◽  
Induced Fit ◽  
Y1 Receptor

Replacement of the carbamoyl residue (R) in reference compound 2 by larger residues (e.g.72) strongly affected Y1R affinity. In case of very bulky carbamoyl substituents (e.g.78), an inverted binding mode was suggested by induced-fit docking.

Design, synthesis and evaluation of a novel cyclohexanamine class of neuropeptide Y Y1 receptor antagonists

2009 ◽  
Vol 19 (16) ◽  
pp. 4781-4785 ◽  
Author(s):  
Kaimei Cho ◽  
Makoto Ando ◽  
Kensuke Kobayashi ◽  
Hiroshi Miyazoe ◽  
Toshiaki Tsujino ◽  
...  
Keyword(s):  
Neuropeptide Y ◽  
Receptor Antagonists ◽  
Design Synthesis ◽  
Y1 Receptor

1,3-Disubstituted benzazepines as neuropeptide Y Y1 receptor antagonists

1999 ◽  
Vol 7 (8) ◽  
pp. 1703-1714 ◽  
Author(s):  
Yasushi Murakami ◽  
Sanji Hagishita ◽  
Tetsuo Okada ◽  
Makoto Kii ◽  
Hiroshi Hashizume ◽  
...  
Keyword(s):  
Neuropeptide Y ◽  
Receptor Antagonists ◽  
Y1 Receptor

Highly Selective and Potent Neuropeptide Y (NPY) Y1 Receptor Antagonists Based on [Pro30, Tyr32, Leu34]NPY(28-36)-NH2(BW1911U90)†

2001 ◽  
Vol 44 (10) ◽  
pp. 1479-1482 ◽  
Author(s):  
Ambikaipakan Balasubramaniam ◽  
Vikas C. Dhawan ◽  
Deborra E. Mullins ◽  
William T. Chance ◽  
Sulaiman Sheriff ◽  
...  
Keyword(s):  
Neuropeptide Y ◽  
Receptor Antagonists ◽  
Y1 Receptor

Neuropeptide Y (NPY) Y1 Receptor Antagonists

2001 ◽  
pp. 672-673
Author(s):  
V. C. Dhawan ◽  
D. E. Mullins ◽  
W. T. Chance ◽  
S. Sheriff ◽  
M. Guzzi ◽  
...  
Keyword(s):  
Neuropeptide Y ◽  
Receptor Antagonists ◽  
Y1 Receptor

Dihydropyridine Neuropeptide Y Y1 Receptor Antagonists

2002 ◽  
Vol 12 (3) ◽  
pp. 379-382 ◽  
Author(s):  
Graham S. Poindexter ◽  
Marc A. Bruce ◽  
Karen L. LeBoulluec ◽  
Ivo Monkovic ◽  
Scott W. Martin ◽  
...  
Keyword(s):  
Neuropeptide Y ◽  
Receptor Antagonists ◽  
Y1 Receptor

1,3-Disubstituted Benzazepines as Novel, Potent, Selective Neuropeptide Y Y1 Receptor Antagonists

1999 ◽  
Vol 42 (14) ◽  
pp. 2621-2632 ◽  
Author(s):  
Yasushi Murakami ◽  
Hirokazu Hara ◽  
Tetsuo Okada ◽  
Hiroshi Hashizume ◽  
Makoto Kii ◽  
...  
Keyword(s):  
Neuropeptide Y ◽  
Receptor Antagonists ◽  
Y1 Receptor

scholarly journals Novel dimeric DOTA-coupled peptidic Y1-receptor antagonists for targeting of neuropeptide Y receptor-expressing cancers

2011 ◽  
Vol 1 (1) ◽  
pp. 21 ◽  
Author(s):  
David Chatenet ◽  
Renzo Cescato ◽  
Beatrice Waser ◽  
Judit Erchegyi ◽  
Jean E Rivier ◽  
...  
Keyword(s):  
Neuropeptide Y ◽  
Receptor Antagonists ◽  
Y1 Receptor ◽  
Neuropeptide Y Receptor

Synthesis and Evaluation of a Series of Novel 2-[(4-Chlorophenoxy)methyl]- benzimidazoles as Selective Neuropeptide Y Y1 Receptor Antagonists

1998 ◽  
Vol 41 (15) ◽  
pp. 2709-2719 ◽  
Author(s):  
Hamideh Zarrinmayeh ◽  
Anne M. Nunes ◽  
Paul L. Ornstein ◽  
Dennis M. Zimmerman ◽  
M. Brian Arnold ◽  
...  
Keyword(s):  
Neuropeptide Y ◽  
Receptor Antagonists ◽  
Y1 Receptor

Induced-Fit Docking Approach Provides Insight into the Binding Mode and Mechanism of Action of HIV-1 Integrase Inhibitors

ChemMedChem ◽  
2009 ◽  
Vol 4 (9) ◽  
pp. 1446-1456 ◽  
Author(s):  
Maria Letizia Barreca ◽  
Nunzio Iraci ◽  
Laura De Luca ◽  
Alba Chimirri
Keyword(s):  
Mechanism Of Action ◽  
Binding Mode ◽  
Integrase Inhibitors ◽  
Induced Fit Docking ◽  
Induced Fit ◽  
Docking Approach ◽  
Insight Into ◽  
Hiv 1

GR231118 (1229U91) and other analogues of the C-terminus of neuropeptide Y are potent neuropeptide Y Y1 receptor antagonists and neuropeptide Y Y4 receptor agonists

1998 ◽  
Vol 349 (1) ◽  
pp. 97-105 ◽  
Author(s):  
Eric M Parker ◽  
Carol K Babij ◽  
Ambikaipakan Balasubramaniam ◽  
Robert E Burrier ◽  
Mario Guzzi ◽  
...  
Keyword(s):  
Neuropeptide Y ◽  
Receptor Antagonists ◽  
Receptor Agonists ◽  
Y1 Receptor ◽  
C Terminus ◽  
Y4 Receptor
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