Talipexole variations as novel bitopic dopamine D2 and D3 receptor ligands

MedChemComm ◽  
2019 ◽  
Vol 10 (11) ◽  
pp. 1926-1929
Author(s):  
Lars Stank ◽  
Annika Frank ◽  
Stefanie Hagenow ◽  
Holger Stark
Keyword(s):  
Dopamine Receptor ◽  
D3 Receptor ◽  
Receptor Ligands ◽  
Dopamine D2

We linked 5,6,7,8-tetrahydro-4H-thiazoloazepine scaffolds with phenylpiperazine pharmacophores to generate bitopic dopamine receptor ligands.

N-(4-(4-(2-Halogenophenyl)piperazin-1-yl)butyl) Substituted Cinnamoyl Amide Derivatives as Dopamine D2 and D3 Receptor Ligands.

ChemInform ◽  
2007 ◽  
Vol 38 (31) ◽  
Author(s):  
Oliver Saur ◽  
Anneke E. Hackling ◽  
Sylvie Perachon ◽  
Jean-Charles Schwartz ◽  
Pierre Sokoloff ◽  
...  
Keyword(s):  
D3 Receptor ◽  
Receptor Ligands ◽  
Dopamine D2 ◽  
Amide Derivatives

scholarly journals Effects of Acute and Chronic Treatments with Dopamine D2 and D3 Receptor Ligands on Cocaine versus Food Choice in Rats

2017 ◽  
Vol 362 (1) ◽  
pp. 161-176 ◽  
Author(s):  
Morgane Thomsen ◽  
Andrew C. Barrett ◽  
Paul Butler ◽  
S. Stevens Negus ◽  
S. Barak Caine
Keyword(s):  
Food Choice ◽  
D3 Receptor ◽  
Receptor Ligands ◽  
Dopamine D2 ◽  
Acute And Chronic Treatments

scholarly journals Controlling receptor function from the extracellular vestibule of G-protein coupled receptors

2020 ◽  
Vol 56 (91) ◽  
pp. 14167-14170
Author(s):  
Attila Egyed ◽  
Katalin Domány-Kovács ◽  
Bence Koványi ◽  
Ferenc Horti ◽  
Dalma Kurkó ◽  
...  
Keyword(s):  
G Protein ◽  
Functional Activity ◽  
Binding Pocket ◽  
G Protein Coupled Receptors ◽  
D3 Receptor ◽  
Receptor Function ◽  
Receptor Ligands ◽  
Dopamine D2 ◽  
G Protein Coupled

Here we show that the functional activity and signalling of dopamine D2 and D3 receptor ligands can be fine tuned from the extracellular secondary binding pocket (SBP) located far from the signalling interface.

scholarly journals Understanding the structural requirements of hybrid (S)-6-((2-(4-phenylpiperazin-1-yl)ethyl)(propyl)amino)-5,6,7,8-tetrahydronaphthalen-1-ol and its analogs as D2/D3 receptor ligands: a 3D QSAR investigation

MedChemComm ◽  
2014 ◽  
Vol 5 (9) ◽  
pp. 1384-1399 ◽  
Author(s):  
Gyan Modi ◽  
Horrick Sharma ◽  
Prashant S. Kharkar ◽  
Aloke K. Dutta
Keyword(s):  
3D Qsar ◽  
Structural Factors ◽  
D3 Receptor ◽  
Receptor Ligands ◽  
Structural Requirements ◽  
Dopamine D2

The present study reports the 3D QSAR of dopamine D2/D3 ligands to gain insights into the structural factors responsible for affinity and D3 selectivity.

Decreased Dopamine D2/D3-Receptor Binding in the Temporal Lobe and the Bilateral Basal Ganglia in patients with Temporal Lobe Epilepsy

2012 ◽  
Vol 43 (01) ◽  
Author(s):  
VE Bernedo Paredes ◽  
H Schwartz ◽  
M Gartenschläger ◽  
M Gartenschläger ◽  
HG Buchholz ◽  
...  
Keyword(s):  
Basal Ganglia ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Receptor Binding ◽  
D3 Receptor ◽  
Dopamine D2

Conformational analysis and molecular modeling of 1-phenyl-, 4-phenyl-, and 1-benzyl-1,2,3,4-tetrahydroisoquinolines as D1 dopamine receptor ligands

1989 ◽  
Vol 32 (9) ◽  
pp. 2050-2058 ◽  
Author(s):  
Paul S. Charifson ◽  
J. Phillip Bowen ◽  
Steven D. Wyrick ◽  
Andrew J. Hoffman ◽  
Michael Cory ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Conformational Analysis ◽  
Dopamine Receptor ◽  
Receptor Ligands ◽  
D1 Dopamine Receptor

Increased Dopamine D2/D3 Receptor Binding After Recovery from Anorexia Nervosa Measured by Positron Emission Tomography and [11C]Raclopride

2005 ◽  
Vol 58 (11) ◽  
pp. 908-912 ◽  
Author(s):  
Guido K. Frank ◽  
Ursula F. Bailer ◽  
Shannan E. Henry ◽  
Wayne Drevets ◽  
Carolyn C. Meltzer ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Anorexia Nervosa ◽  
Receptor Binding ◽  
Emission Tomography ◽  
D3 Receptor ◽  
Dopamine D2 ◽  
Positron Emission
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