scholarly journals The cytotoxic potential of cationic triangulenes against tumour cells

MedChemComm ◽  
2019 ◽  
Vol 10 (11) ◽  
pp. 1881-1891 ◽  
Author(s):  
Euphemia Leung ◽  
Lisa I. Pilkington ◽  
Mohinder M. Naiya ◽  
David Barker ◽  
Ayesha Zafar ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Tumour Cells ◽  
Cytotoxic Potential ◽  
Dna Intercalators

Close-shelled carbocations DNA intercalators Pr-ADOTA and Pr-DAOTA are very cytotoxic against the cancer cell lines MDA-MB-231 (breast) and HCT116 (colon).

A Review on Camptothecin Analogs with Promising Cytotoxic Profile

2019 ◽  
Vol 18 (13) ◽  
pp. 1796-1814 ◽  
Author(s):  
Sk. Abdul Amin ◽  
Nilanjan Adhikari ◽  
Tarun Jha ◽  
Shovanlal Gayen
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Structure Property ◽  
Cytotoxic Potential ◽  
Structure Property Relationships ◽  
Structure Activity ◽  
Camptothecin Analogs ◽  
Pharmacokinetic Properties ◽  
Quantitative Structure Activity Relationships

Camptothecin (CPT), obtained from Camptotheca acuminata (Nyssaceae), is a quinoline type of alkaloid. Apart from various traditional uses, it is mainly used as a potential cytotoxic agent acting against a variety of cancer cell lines. Though searches have been continued for last six decades, still it is a demanding task to design potent and cytotoxic CPTs. Different CPT analogs are synthesized to enhance the cytotoxic potential as well as to increase the pharmacokinetic properties of these analogs. Some of these analogs were proven to be clinically effective in different cancer cell lines. In this article, different CPT analogs have been highlighted extensively to get a detail insight about the structure-property relationships as well as different quantitative structure-activity relationships (QSARs) modeling of these analogs are also discussed. This study may be beneficial for designing newer CPT analogs in future.

Evaluation of the Cytotoxic Potential of Natural Products Employing a Battery of Human Cancer Cell Lines

Planta Medica ◽  
1990 ◽  
Vol 56 (06) ◽  
pp. 673-673
Author(s):  
J. Pezzuto ◽  
C. Beattie ◽  
K Lowell ◽  
W. Mar ◽  
S. Swanson ◽  
...  
Keyword(s):  
Natural Products ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Cytotoxic Potential ◽  
Human Cancer Cell Lines

scholarly journals Selective Cytotoxic Potential of IFN-γ and TNF-α on Breast Cancer Cell Lines (T47D and MCF7)

2015 ◽  
Vol 11 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Wahyu Widowati ◽  
Harry Murti ◽  
Diana Krisanti Jasaputra ◽  
Sutiman B. Sumitro ◽  
M. Aris Widodo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Lines ◽  
Breast Cancer Cell Lines ◽  
Cytotoxic Potential ◽  
Tnf Α ◽  
Ifn Γ

scholarly journals Cytotoxic potential of sponge extracts from Mauritius Waters on human cancer cell lines

2020 ◽  
Vol 5 (3) ◽  
Author(s):  
Prerna Roy ◽  
Avin Ramanjooloo ◽  
Jay Rovisham Singh Doorga ◽  
Girish Beedessee ◽  
Thierry Cresteil ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Cytotoxic Potential ◽  
Human Cancer Cell Lines

scholarly journals Synthesis and In Vitro Cytotoxic Activity of Chromenopyridones

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Balwinder Singh ◽  
Vishal Sharma ◽  
Gagandeep Singh ◽  
Rakesh Kumar ◽  
Saroj Arora ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Hep G2 ◽  
Cytotoxic Potential ◽  
Human Cancer Cell Lines ◽  
Mcf 7

Novel substituted chromenopyridones (3a–j and 6a–d) were synthesized and evaluated in vitro for the cytotoxic activity against various human cancer cell lines such as prostate (PC-3), breast (MCF-7), CNS (IMR-32), cervix (Hela), and liver (Hep-G2). preliminary cytotoxic screening showed that all the compounds possess a good to moderate inhibitory activity against various cancer cell lines. Particularly, compound 6b bearing allyl moiety displayed a significant cytotoxic potential in comparison to standard drugs.

scholarly journals Detection of circulating tumour cells on mRNA levels with established breast cancer cell lines

2012 ◽  
Vol 1 (2) ◽  
pp. 231-234
Author(s):  
MICHAEL ZEBISCH ◽  
ALEXANDRA C. KÖLBL ◽  
ULRICH ANDERGASSEN ◽  
STEPHAN HUTTER ◽  
JULIA NEUGEBAUER ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Lines ◽  
Tumour Cells ◽  
Breast Cancer Cell Lines ◽  
Mrna Levels ◽  
Circulating Tumour Cells
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