Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines to develop functionalized ligands to target adenosine receptors: fluorescent ligands as an example

Stephanie Federico; Enrico Margiotta; Silvia Paoletta; Sonja Kachler; Karl-Norbert Klotz; Kenneth A. Jacobson; Giorgia Pastorin; Stefano Moro; Giampiero Spalluto

doi:10.1039/c9md00014c

Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines to develop functionalized ligands to target adenosine receptors: fluorescent ligands as an example

MedChemComm ◽

10.1039/c9md00014c ◽

2019 ◽

Vol 10 (7) ◽

pp. 1094-1108 ◽

Cited By ~ 3

Author(s):

Stephanie Federico ◽

Enrico Margiotta ◽

Silvia Paoletta ◽

Sonja Kachler ◽

Karl-Norbert Klotz ◽

...

Keyword(s):

Adenosine Receptor ◽

Adenosine Receptors ◽

Receptor Antagonists ◽

Fluorescent Ligands ◽

Functionalized Ligands

A series of adenosine receptor antagonists bearing a reactive linker was developed.

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Conjugable A3 adenosine receptor antagonists for the development of functionalized ligands and their use in fluorescent probes

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2019.111886 ◽

2020 ◽

Vol 186 ◽

pp. 111886 ◽

Cited By ~ 3

Author(s):

Stephanie Federico ◽

Enrico Margiotta ◽

Stefano Moro ◽

Eszter Kozma ◽

Zhan-Guo Gao ◽

...

Keyword(s):

Fluorescent Probes ◽

Adenosine Receptor ◽

Receptor Antagonists ◽

A3 Adenosine Receptor ◽

Functionalized Ligands

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Reversal of the antiinflammatory effects of methotrexate by the nonselective adenosine receptor antagonists theophylline and caffeine: Evidence that the antiinflammatory effects of methotrexate are mediated via multiple adenosine receptors in rat adjuvant arthritis

Arthritis & Rheumatism ◽

10.1002/1529-0131(200003)43:3<656::aid-anr23>3.0.co;2-h ◽

2000 ◽

Vol 43 (3) ◽

pp. 656 ◽

Cited By ~ 115

Author(s):

M. Carmen Montesinos ◽

Josephine S. Yap ◽

Avani Desai ◽

Inmaculada Posadas ◽

Christine T. McCrary ◽

...

Keyword(s):

Adenosine Receptor ◽

Adenosine Receptors ◽

Adjuvant Arthritis ◽

Receptor Antagonists ◽

Rat Adjuvant Arthritis ◽

Antiinflammatory Effects

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Ligand-Based Virtual Screening Using Tailored Ensembles: A Prioritization Tool for Dual A2A Adenosine Receptor Antagonists / Monoamine Oxidase B Inhibitors

Current Pharmaceutical Design ◽

10.2174/1381612822666160302103542 ◽

2016 ◽

Vol 22 (21) ◽

pp. 3082-3096 ◽

Cited By ~ 7

Author(s):

Aliuska Morales Helguera ◽

Yunierkis Perez-Castillo ◽

M. Natália D.S. Cordeiro ◽

Eduardo Tejera ◽

César Paz-y-Miño ◽

...

Keyword(s):

Virtual Screening ◽

Monoamine Oxidase ◽

Adenosine Receptor ◽

Monoamine Oxidase B ◽

Receptor Antagonists ◽

A2a Adenosine Receptor

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A3 Adenosine Receptor Antagonists

Mini-Reviews in Medicinal Chemistry ◽

10.2174/1389557510101040417 ◽

2001 ◽

Vol 1 (4) ◽

pp. 417-427 ◽

Cited By ~ 12

Author(s):

C. Muller

Keyword(s):

Adenosine Receptor ◽

Receptor Antagonists ◽

A3 Adenosine Receptor

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A2A Adenosine Receptor Antagonists as Therapeutic Candidates: Are They Still an Interesting Challenge?

Mini-Reviews in Medicinal Chemistry ◽

10.2174/1389557518666180423113051 ◽

2018 ◽

Vol 18 (14) ◽

pp. 1168-1174 ◽

Cited By ~ 8

Author(s):

Barbara Cacciari ◽

Giampiero Spalluto ◽

Stephanie Federico

Keyword(s):

Adenosine Receptor ◽

Receptor Antagonists ◽

A2a Adenosine Receptor

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Adenosine receptor antagonists inhibit the development of morphine sensitization in the C57BL/6 mouse

Neuroscience Letters ◽

10.1016/s0304-3940(99)00188-3 ◽

1999 ◽

Vol 264 (1-3) ◽

pp. 89-92 ◽

Cited By ~ 21

Author(s):

Stuart P Weisberg ◽

Gary B Kaplan

Keyword(s):

Adenosine Receptor ◽

Receptor Antagonists

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Pyrazolo[1,5-c]quinazoline derivatives and their simplified analogues as adenosine receptor antagonists: Synthesis, structure–affinity relationships and molecular modeling studies

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2012.10.031 ◽

2013 ◽

Vol 21 (1) ◽

pp. 283-294 ◽

Cited By ~ 32

Author(s):

Daniela Catarzi ◽

Vittoria Colotta ◽

Flavia Varano ◽

Daniela Poli ◽

Lucia Squarcialupi ◽

...

Keyword(s):

Molecular Modeling ◽

Adenosine Receptor ◽

Receptor Antagonists ◽

Modeling Studies ◽

Molecular Modeling Studies ◽

Quinazoline Derivatives

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Tetrahydrobenzothiophenone Derivatives as a Novel Class of Adenosine Receptor Antagonists†

Journal of Medicinal Chemistry ◽

10.1021/jm9504823 ◽

1996 ◽

Vol 39 (2) ◽

pp. 398-406 ◽

Cited By ~ 12

Author(s):

A. Michiel van Rhee ◽

Suhaib M. Siddiqi ◽

Neli Melman ◽

Dan Shi ◽

William L. Padgett ◽

...

Keyword(s):

Adenosine Receptor ◽

Receptor Antagonists

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Pyrazolo-triazolo-pyrimidines as adenosine receptor antagonists: A complete structure–activity profile

Purinergic Signalling ◽

10.1007/s11302-006-9027-x ◽

2006 ◽

Vol 3 (3) ◽

pp. 183-193 ◽

Cited By ~ 13

Author(s):

Barbara Cacciari ◽

Chiara Bolcato ◽

Giampiero Spalluto ◽

Karl-Norbet Klotz ◽

Magdalena Bacilieri ◽

...

Keyword(s):

Adenosine Receptor ◽

Activity Profile ◽

Receptor Antagonists ◽

Complete Structure ◽

Structure Activity

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Synthesis and pharmacological characterization of a new series of 5,7-disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazine derivatives as adenosine receptor antagonists: A preliminary inspection of ligand–receptor recognition process

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2010.02.039 ◽

2010 ◽

Vol 18 (7) ◽

pp. 2524-2536 ◽

Cited By ~ 25

Author(s):

Giorgia Pastorin ◽

Stephanie Federico ◽

Silvia Paoletta ◽

Marta Corradino ◽

Francesca Cateni ◽

...

Keyword(s):

Adenosine Receptor ◽

Receptor Antagonists ◽

Pharmacological Characterization ◽

Recognition Process ◽

Receptor Recognition ◽

Triazine Derivatives

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