On-demand sample injection: combining acoustic actuation with a tear-drop shaped nozzle to generate droplets with precise spatial and temporal control

Lab on a Chip ◽  
2020 ◽  
Vol 20 (2) ◽  
pp. 253-265 ◽  
Author(s):  
Jason C. Brenker ◽  
Citsabehsan Devendran ◽  
Adrian Neild ◽  
Tuncay Alan
Keyword(s):  
Controlled Delivery ◽  
Scientific Instruments ◽  
Temporal Control ◽  
Injection Method ◽  
Sample Injection ◽  
On Demand ◽  
Liquid Samples ◽  
Acoustic Actuation ◽  
Shaped Nozzle

An on-demand droplet injection method for controlled delivery of nanolitre-volume liquid samples to scientific instruments for subsequent analysis is presented.

Simultaneous separation and sensitive detection of four β2-agonists in biological specimens by CE-UV using a field-enhanced sample injection method

2015 ◽  
Vol 7 (1) ◽  
pp. 175-180 ◽  
Author(s):  
Cheng Chen ◽  
Lingchen Meng ◽  
Meixian Li ◽  
Zhiwei Zhu
Keyword(s):  
Cost Effective ◽  
Sensitive Detection ◽  
Injection Method ◽  
Sample Injection ◽  
Simultaneous Separation ◽  
Sensitive Determination ◽  
Β2 Agonists

A rapid, sensitive and cost-effective CE-UV method has been developed for the simultaneous separation and sensitive determination of four beta2-agonists.

scholarly journals Fabrication of a 3D Teflon microdevice for energy free homogeneous liquid flow inside a long microchannel and its application to continuous-flow PCR

RSC Advances ◽  
2017 ◽  
Vol 7 (18) ◽  
pp. 10624-10630 ◽  
Author(s):  
Kieu The Loan Trinh ◽  
Wenming Wu ◽  
Nae Yoon Lee
Keyword(s):  
Liquid Flow ◽  
Continuous Flow ◽  
Homogeneous Liquid ◽  
Injection Method ◽  
Sample Injection ◽  
Single Heater

The 3D spiral PTFE microdevice was fabricated for performing continuous-flow PCR using a single heater and via semi-automated sample injection method.

scholarly journals Biohybrid Microswimmers Against Bacterial Infections

2021 ◽  
Author(s):  
Inga S. Shchelik ◽  
João V. D. Molino ◽  
Karl Gademann
Keyword(s):  
Bacterial Infections ◽  
Surface Engineering ◽  
High Efficiency ◽  
Dimensional Space ◽  
Three Dimensional ◽  
Covalent Attachment ◽  
Temporal Control ◽  
Selective Treatment ◽  
On Demand

Biohybrid microswimmers exploit the natural abilities of motile microorganisms e.g. in releasing cargo on-demand with high spatial and temporal control. However, using such engineered swarms to deliver antibiotics addressing bacterial infections has not yet been realized. In the present study, a design strategy for biohybrid microswimmers is reported, which features the covalent attachment of antibiotics to the motile green algae Chlamydomonas reinhardtii via a photo-cleavable linker. The surface engineering of the algae does not rely on genetic manipulations, proceeds with high efficiency, does not impair the viability or phototactic ability of microalgae, and allows for caging of the antibiotic on the surface for subsequent release via external stimuli. Two different antibiotic classes have been separately utilized, which result in activity against both gram-positive and gram-negative strains. Guiding the biohybrid microswimmers by an external beacon, and on-demand delivery of the drugs by light with high spatial and temporal control, allowed for strong inhibition of bacterial growth in vivo. This efficient strategy could potentially allow for the selective treatment of bacterial infections by engineered algal microrobots with high precision in space and time. Overall, this work presents an operationally simple production of biohybrid microswimmers loaded with antibiotic cargo to combat bacterial infections precisely delivered in three-dimensional space.

Spatial and temporal control of on-demand propane–air flame ignition by active photothermal effect of aluminum nanoenergetics

2013 ◽  
Vol 160 (9) ◽  
pp. 1842-1847 ◽  
Author(s):  
Jacques E. Abboud ◽  
Naibo Jiang ◽  
Zhili Zhang ◽  
Sukesh Roy ◽  
James R. Gord
Keyword(s):  
Photothermal Effect ◽  
Temporal Control ◽  
On Demand ◽  
Flame Ignition
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