Single-cell imaging of AuNPs and AgNPs by near-field desorption ionization mass spectrometry

2020 ◽  
Vol 35 (5) ◽  
pp. 927-932 ◽  
Author(s):  
Xiaoling Cheng ◽  
Tongtong Wang ◽  
Zhibin Yin ◽  
Wei Hang
Keyword(s):  
Mass Spectrometry ◽  
Single Cell ◽  
Cell Imaging ◽  
Near Field ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Field Desorption ◽  
Desorption Ionization ◽  
Single Cell Imaging

Nanoparticles (NPs) have prospective applications in the field of biomedicine and biotechnology.

Chemical and Topographical Single‐Cell Imaging by Near‐Field Desorption Mass Spectrometry

2019 ◽  
Vol 131 (14) ◽  
pp. 4589-4594 ◽  
Author(s):  
Zhibin Yin ◽  
Xiaoling Cheng ◽  
Rong Liu ◽  
Xiaoping Li ◽  
Le Hang ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Single Cell ◽  
Cell Imaging ◽  
Near Field ◽  
Field Desorption ◽  
Desorption Mass Spectrometry ◽  
Single Cell Imaging ◽  
Field Desorption Mass Spectrometry

scholarly journals From the discovery of field ionization to field desorption and liquid injection field desorption/ionization-mass spectrometry—A journey from principles and applications to a glimpse into the future

2020 ◽  
Vol 26 (4) ◽  
pp. 241-273 ◽  
Author(s):  
Jürgen H Gross
Keyword(s):  
Mass Spectrometry ◽  
Ionization Mass Spectrometry ◽  
Field Ionization ◽  
Ionization Mass ◽  
Field Desorption ◽  
Magnetic Sector ◽  
Desorption Ionization ◽  
Liquid Injection ◽  
The Future ◽  
Modern Mass

The discovery of the ionizing effect of strong electric fields in the order of volts per Ångstrom in the early 1950s eventually led to the development of field ionization-mass spectrometry (FI-MS). Due to the very low ion currents, and thus, limited by the instrumentation of the 1960s, it took some time for the, by then, new technique to become adopted for analytical applications. In FI-MS, volatile or at least vaporizable samples mainly deliver molecular ions, and consequently, mass spectra showing no or at least minor numbers of fragment ion signals. The next major breakthrough was achieved by overcoming the need to evaporate the analyte prior to ionization. This was accomplished in the early 1970s by simply depositing the samples onto the field emitter and led to field desorption-mass spectrometry (FD-MS). With FD-MS, a desorption ionization method had become available that paved the road to the mass spectral analysis of larger molecules of low to high polarity and even of organic salts. In FD-MS, all of these analytes deliver spectra with no or at least few fragment ion peaks. The last milestone was the development of liquid injection field desorption/ionization (LIFDI) in the early 2000s that allows for sample deposition under the exclusion of atmospheric oxygen and water. In addition to sampling under inert conditions, LIFDI also enables more robust and quicker operation than classical FI-MS and FD-MS procedures. The development and applications of FI, FD, and LIFDI had mutual interference with the mass analyzers that were used in combination with these methods. Vice versa, the demand for using these techniques on other than magnetic sector instruments has effectuated their adaptation to different types of modern mass analyzers. The journey started with magnetic sector instruments, almost skipped quadrupole analyzers, encompassed Fourier transform ion cyclotron resonance (FT-ICR) and orthogonal acceleration time-of-flight (oaTOF) analyzers, and finally arrived at Orbitraps. Even interfaces for continuous-flow LIFDI have been realized. Even though being niche techniques to some degree, one may be confident that FI, FD, and LIFDI have a promising future ahead of them. This Account takes you on the journey from principles and applications of the title methods to a glimpse into the future.

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