One-pot synthesis of tetrahydro-pyrrolobenzodiazepines and tetrahydro-pyrrolobenzodiazepinones through sequential 1,3-dipolar cycloaddition/N-alkylation (N-acylation)/Staudinger/aza-Wittig reactions

2019 ◽  
Vol 21 (16) ◽  
pp. 4489-4494 ◽  
Author(s):  
Xiaoming Ma ◽  
Xiaofeng Zhang ◽  
John Mark Awad ◽  
Guoshu Xie ◽  
Weiqi Qiu ◽  
...  
Keyword(s):  
Green Chemistry ◽  
Dipolar Cycloaddition ◽  
Diastereoselective Synthesis ◽  
One Pot ◽  
One Pot Synthesis ◽  
Wittig Reactions ◽  
Reaction Processes

A new diastereoselective synthesis of benzodiazepines and diazepinones is developed. This one-pot and three-step synthesis of four components gave two different heterocyclic scaffolds. Green chemistry metrics analysis of the reaction processes provided favorable results.

Hypervalent-Iodine Mediated One-Pot Synthesis of Isoxazolines and Isoxazoles bearing Difluoromethyl Phosphonate Moiety

2021 ◽  
Author(s):  
Romana Pajkert ◽  
Henryk Koroniak ◽  
Pawel Kafarski ◽  
Gerd Volker Roeschenthaler
Keyword(s):  
Nitrile Oxide ◽  
Dipolar Cycloaddition ◽  
Hypervalent Iodine ◽  
One Pot ◽  
One Pot Synthesis

A one-pot, regioselective 1,3-dipolar cycloaddition of in situ generated (diethoxyphosphoryl)difluoromethyl nitrile oxide toward selected alkenes and alkynes is reported. This protocol enables facile access to 3,5-disubstituted isoxazolines and isoxazoles bearing...

scholarly journals Organocatalytic Enantioselective Cascade Michael−Michael−Wittig Reactions of Phosphorus Ylides: One-Pot Synthesis of theall-cisTrisubstituted Cyclohexenecarboxylates via the [1 + 2 + 3] Annulation

2009 ◽  
Vol 11 (22) ◽  
pp. 5246-5249 ◽  
Author(s):  
Bor-Cherng Hong ◽  
Rei-Hau Jan ◽  
Chih-Wei Tsai ◽  
Roshan Y. Nimje ◽  
Ju-Hsiou Liao ◽  
...  
Keyword(s):  
Phosphorus Ylides ◽  
One Pot ◽  
One Pot Synthesis ◽  
Wittig Reactions

One-pot synthesis of new triazole-sucrose derivatives via click chemistry and evaluation of their antitubercular activity

2016 ◽  
Vol 22 (4) ◽  
Author(s):  
Khaoula Hajlaoui ◽  
Ahlem Guesmi ◽  
Naoufel Ben Hamadi ◽  
Moncef Msaddek
Keyword(s):  
Click Chemistry ◽  
Copper Nanoparticles ◽  
Antitubercular Activity ◽  
Antimycobacterial Activity ◽  
Dipolar Cycloaddition ◽  
One Pot ◽  
Effective Catalyst ◽  
One Pot Synthesis

AbstractReadily prepared copper nanoparticles are an effective catalyst for 1,3-dipolar cycloaddition of carbohydrate azide and a variety of alkynes that furnishes the corresponding 1,2,3-triazole-sucrose derivatives in excellent yields. Products were screened for their antimycobacterial activity against

ChemInform Abstract: A One-Pot Synthesis and 1,3-Dipolar Cycloaddition of [1,2]Dithiolo[4,3-b]indole-3(4H)-thiones.

ChemInform ◽  
2009 ◽  
Vol 40 (30) ◽  
Author(s):  
Lidia S. Konstantinova ◽  
Kirill A. Lysov ◽  
Stanislav A. Amelichev ◽  
Natalia V. Obruchnikova ◽  
Oleg A. Rakitin
Keyword(s):  
Dipolar Cycloaddition ◽  
One Pot ◽  
One Pot Synthesis
Sign in / Sign up

Export Citation Format

Share Document