Amelioration of clinical course and demyelination in the cuprizone mouse model in relation to ketogenic diet

2020 ◽  
Vol 11 (6) ◽  
pp. 5647-5663 ◽  
Author(s):  
Ning Zhang ◽  
Chunhong Liu ◽  
Ruiyan Zhang ◽  
Li Jin ◽  
Xiaohan Yin ◽  
...  
Keyword(s):  
Mouse Model ◽  
Ketogenic Diet ◽  
Clinical Course ◽  
High Fat ◽  
Carbohydrate Diet ◽  
Neuroprotective Effects ◽  
Low Carbohydrate Diet ◽  
Low Carbohydrate

Ketogenic diet (KD) is defined as a high-fat, low-carbohydrate diet with appropriate amounts of protein, which has broad neuroprotective effects.

scholarly journals Ketogenic Diet-Induced Severe Ketoacidosis in a Lactating Woman: A Case Report and Review of the Literature

2019 ◽  
Vol 2019 ◽  
pp. 1-4
Author(s):  
Benedicta Nneoma Nnodum ◽  
Eziafa Oduah ◽  
David Albert ◽  
Mark Pettus
Keyword(s):  
Ketogenic Diet ◽  
Case Reports ◽  
High Fat ◽  
Carbohydrate Diet ◽  
Low Carbohydrate Diet ◽  
Lactating Mothers ◽  
Low Carbohydrate ◽  
Life Threatening ◽  
Clinically Significant ◽  
Prompt Diagnosis

The ketogenic diet (KD) is a high-fat, adequate-protein, and low-carbohydrate diet that leads to nutritional ketosis and weight loss. It is known to induce ketosis but is not an established cause of clinically significant ketoacidosis. Lactation ketoacidosis is well established in bovine literature but remains a rare phenomenon in humans. Here we present a life-threatening case of severe ketoacidosis in a nondiabetic lactating mother on a strict ketogenic diet. We review the available case reports of lactation ketoacidosis in humans and the mechanisms thereof. Although ketogenic diet has been shown to be safe in nonpregnant individuals, the safety of this diet in lactating mothers is not known. Health professionals and mothers should be made aware of the potential risk associated with a strict ketogenic diet when combined with lactation. Prompt diagnosis and immediate treatment cannot be overemphasized. To our knowledge, this is the first reported case of life-threatening lactation ketoacidosis associated with ketogenic diet while consuming an adequate number of calories per day.

scholarly journals Long-Term Ketogenic Diet Induces Metabolic Acidosis, Anemia, and Oxidative Stress in Healthy Wistar Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-7 ◽  
Author(s):  
Aryadi Arsyad ◽  
Irfan Idris ◽  
Andi A. Rasyid ◽  
Rezky A. Usman ◽  
Kiki R. Faradillah ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Metabolic Acidosis ◽  
Ketogenic Diet ◽  
Wistar Rats ◽  
Blood Gas ◽  
High Fat ◽  
Carbohydrate Diet ◽  
Low Carbohydrate Diet ◽  
Low Carbohydrate

Background. Ketogenic diet has been used as supportive therapy in a range of conditions including epilepsy, diabetes mellitus, and cancer. Objective. This study aimed to investigate the effects of long-term consumption of ketogenic diet on blood gas, hematological profiles, organ functions, and superoxide dismutase level in a rat model. Materials and Methods. Fifteen male Wistar rats were divided into control (n = 8) and ketogenic (n = 7) groups. Controls received standard diet contained 52.20% of carbohydrates, 7.00% fat, and 15.25% protein; meanwhile, the ketogenic group received a high-fat-low-carbohydrate diet which contained 5.66% of carbohydrate, 86.19% fat, and 8.15% protein. All rats were caged individually and received 30g of either standard or high-fat-low-carbohydrate pellets. The experiment was carried out for 60 days before the blood samples were taken and analyzed to obtain blood gas, cell counts, organ biomarkers, and plasma antioxidant superoxide dismutase (SOD) levels. Results. The rats subjected to ketogenic diet experienced a marked decrease in body weight, blood sugar, and increased blood ketones (p<0.05). The average blood pH was 7.36 ± 0.02 and base excess was −5.57 ± 2.39 mOsm/L, which were significantly lower than controls (p<0.05). Hematological analysis showed significantly lower erythrocyte, hemoglobin, and hematocrit levels. No significant changes were found in alanine aminotransferase, aspartate aminotransferase, urea, and creatinine levels, indicating normal liver and kidney functions. Nevertheless, plasma SOD level significantly reduced with ketogenic diet. Conclusion. Long-term ketogenic diet induces metabolic acidosis, anemia, and reduced antioxidant enzyme level in rats following 60 days of consuming high-fat-low-carbohydrate diet.

scholarly journals Popular Diets: Ketogenic Diet

EDIS ◽  
2020 ◽  
Vol 2020 (5) ◽  
Author(s):  
Kelsey Gemmill ◽  
Daniela Rivero-Mendoza ◽  
Wendy J. Dahl
Keyword(s):  
Social Media ◽  
Weight Loss ◽  
Ketogenic Diet ◽  
Human Nutrition ◽  
Food Science ◽  
High Fat ◽  
Carbohydrate Diet ◽  
Low Carbohydrate Diet ◽  
The Past ◽  
Low Carbohydrate

The ketogenic diet is a high-fat, very low carbohydrate diet. The first documented use of the ketogenic diet was in 1921 to treat epilepsy in children. In the past few years, the ketogenic diet has resurged in popularity as a potential means for weight loss. The ketogenic diet has become popular due to celebrity endorsement and social media influences. This new 4-page publication of the UF/IFAS Food Science and Human Nutrition Department explains the concepts behind this diet, explores the available menu, and examines whether this diet is safe and effective. Written by Kelsey Gemmill, Daniela Rivero-Mendoza, and Wendy Dahl.https://edis.ifas.ufl.edu/fs403

scholarly journals Ketogenic Diet in Epileptic Encephalopathies

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Suvasini Sharma ◽  
Manjari Tripathi
Keyword(s):  
Ketogenic Diet ◽  
Refractory Epilepsy ◽  
Dravet Syndrome ◽  
High Fat ◽  
Carbohydrate Diet ◽  
Epileptic Encephalopathies ◽  
Low Carbohydrate Diet ◽  
Ohtahara Syndrome ◽  
Low Carbohydrate ◽  
Atonic Seizures

The ketogenic diet is a medically supervised high-fat, low-carbohydrate diet that has been found useful in patients with refractory epilepsy. It has been shown to be effective in treating multiple seizure types and epilepsy syndromes. In this paper, we review the use of the ketogenic diet in epileptic encephalopathies such as Ohtahara syndrome, West syndrome, Dravet syndrome, epilepsy with myoclonic atonic seizures, and Lennox-Gastaut syndrome.

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