Production of GABA-enriched idli with ACE inhibitory and antioxidant properties using Aspergillus oryzae: the antihypertensive effects in spontaneously hypertensive rats

2020 ◽  
Vol 11 (5) ◽  
pp. 4304-4313 ◽  
Author(s):  
Mohsen Zareian ◽  
Ehsan Oskoueian ◽  
Marjan Majdinasab ◽  
Bita Forghani
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Antioxidant Properties ◽  
Fermented Food ◽  
Aminobutyric Acid ◽  
Converting Enzyme ◽  
Hypertensive Rats ◽  
Angiotensin I ◽  
Spontaneously Hypertensive ◽  
Angiotensin I Converting Enzyme ◽  
Ace Inhibitory

The present study aimed to develop a fermented food (idli) with enhanced γ-aminobutyric acid (GABA) and angiotensin I-converting enzyme (ACE) inhibitory properties using a GABA-producing fungus.

A novel angiotensin-I converting enzyme inhibitory peptide derived from the glutelin of vinegar soaked black soybean and its antihypertensive effect in spontaneously hypertensive rats

2019 ◽  
Vol 166 (3) ◽  
pp. 223-230 ◽  
Author(s):  
Yueyuan Zhang ◽  
Yanling Zhang ◽  
Peiyao Chen ◽  
Fengjue Shu ◽  
Kai Li ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Spontaneously Hypertensive Rats ◽  
Converting Enzyme ◽  
Hypertensive Rats ◽  
Angiotensin I ◽  
Ace Inhibitory Activity ◽  
Spontaneously Hypertensive ◽  
Black Soybean ◽  
Angiotensin I Converting Enzyme ◽  
Ace Inhibitory

AbstractVinegar soaked black soybean is a traditional Chinese food widely used for the treatment of hypertension. While its pharmacodynamic substance was not fully unveiled. It contained abundant glutelin, thus the purpose of this study was to obtain potent antihypertensive peptides from vinegar soaked black soybean. Black soybean was soaked with vinegar and then glutelin was first catalyzed by alcalase. Ultrafiltration, ion exchange chromatography and reversed-phase high performance liquid chromatography were sequentially applied to separate and purify the angiotensin-I converting enzyme (ACE) inhibitory peptides from glutelin hydrolysates. As a result, the fraction L1-4 with the highest ACE inhibitory activity (83.41%) at the final concentration of 0.01 mg/ml was obtained and five peptides were then identified. These peptides were further optimized by virtual screening combining with in silico proteolysis. Finally, a novel tetrapeptide Phe-Gly-Ser-Phe (FGSF) was obtained. FGSF exhibited high in vitro ACE inhibitory activity (IC50 = 117.11 μM) and in vivo hypotensive effect which maximally reduced systolic blood pressure of 21.95 mmHg at 20 mg/kg body weight in spontaneously hypertensive rats. Our study demonstrated that FGSF derived from vinegar soaked black soybean might be used as a promising ingredient for pharmaceuticals against hypertension and its related diseases.

Characterization of signaling pathways of Angiotensin I‐Converting Enzyme in mesangial cells of spontaneously hypertensive rats (SHR)

2011 ◽  
Vol 25 (S1) ◽  
Author(s):  
Rosana Inácio Reis ◽  
Lucas Tabajara Parreiras‐e‐Silva ◽  
Christiane Becari ◽  
Maria Claudina Andrade ◽  
Maria Cristina Oliveira Salgado ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Spontaneously Hypertensive Rats ◽  
Mesangial Cells ◽  
Converting Enzyme ◽  
Hypertensive Rats ◽  
Angiotensin I ◽  
Spontaneously Hypertensive ◽  
Angiotensin I Converting Enzyme
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