Cuscuta chinensis flavonoids down-regulate the DNA methylation of the H19/Igf2 imprinted control region and estrogen receptor alpha promoter of the testis in bisphenol A exposed mouse offspring

2020 ◽  
Vol 11 (1) ◽  
pp. 787-798 ◽  
Author(s):  
Yuanyuan Wei ◽  
Chao Han ◽  
Shuying Li ◽  
Yuqing Cui ◽  
Yongzhan Bao ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Estrogen Receptor ◽  
Bisphenol A ◽  
Control Region ◽  
Estrogen Receptor Alpha ◽  
Emerging Contaminant ◽  
Reproductive Disorders ◽  
Receptor Alpha ◽  
Cuscuta Chinensis

Exposure to the emerging contaminant bisphenol A (BPA) is ubiquitous and associated with reproductive disorders.

scholarly journals Perinatal exposure to low-dose bisphenol A disrupts learning/memory and DNA methylation of estrogen receptor alpha in the hippocampus

2016 ◽  
Vol 5 (3) ◽  
pp. 828-835 ◽  
Author(s):  
Huailong Chang ◽  
Mu Wang ◽  
Wei Xia ◽  
Tian Chen ◽  
Wenqian Huo ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Estrogen Receptor ◽  
Bisphenol A ◽  
Brain Development ◽  
Estrogen Receptor Alpha ◽  
Low Dose ◽  
Perinatal Exposure ◽  
Developmental Exposure ◽  
Receptor Alpha ◽  
And Behaviors

Developmental exposure to bisphenol A (BPA) has been indicated to pose long-lasting effects on brain development and behaviors in adulthood.

scholarly journals DNA methylation and demethylation underlie the sex difference in estrogen receptor alpha in the arcuate nucleus

2021 ◽  
Author(s):  
Laura R. Cortes ◽  
Carla D. Cisternas ◽  
Iagn N. K. V. Cabahug ◽  
Damian Mason ◽  
Emma K. Ramlall ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Estrogen Receptor ◽  
Sex Difference ◽  
Estrogen Receptor Alpha ◽  
Arcuate Nucleus ◽  
Receptor Alpha

scholarly journals Hormone-Like Effects of Bisphenol A on p53 and Estrogen Receptor Alpha in Breast Cancer Cells

2019 ◽  
Vol 8 (1) ◽  
pp. 169-184 ◽  
Author(s):  
Victoria Lloyd ◽  
Mia Morse ◽  
Betsy Purakal ◽  
Jordan Parker ◽  
Paige Benard ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Bisphenol A ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Estrogen Receptor Alpha ◽  
Receptor Alpha

Bisphenol a regulates the estrogen receptor alpha signaling in developing hippocampus of male rats through estrogen receptor

Hippocampus ◽  
2014 ◽  
Vol 24 (12) ◽  
pp. 1570-1580 ◽  
Author(s):  
Xiao-Bin Xu ◽  
Ye He ◽  
Chen Song ◽  
Xin Ke ◽  
Shi-Jun Fan ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Bisphenol A ◽  
Estrogen Receptor Alpha ◽  
Male Rats ◽  
Receptor Alpha

scholarly journals Discovery of a Novel Seminal Fluid Microbiome and Influence of Estrogen Receptor Alpha Genetic Status

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Angela B. Javurek ◽  
William G. Spollen ◽  
Amber M. Mann Ali ◽  
Sarah A. Johnson ◽  
Dennis B. Lubahn ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Estrogen Receptor ◽  
Estrogen Receptor Alpha ◽  
Seminal Fluid ◽  
Reproductive Function ◽  
Adult Health ◽  
Reproductive Disorders ◽  
Bacterial Composition ◽  
Receptor Alpha ◽  
Health And Disease

Abstract Bacteria harbored in the male reproductive system may influence reproductive function and health of the male and result in developmental origins of adult health and disease (DOHaD) effects in his offspring. Such effects could be due to the seminal fluid, which is slightly basic and enriched with carbohydrates; thereby, creating an ideal habitat for microbes or a potential seminal fluid microbiome (SFM). Using wild-type (WT) and estrogen receptor-alpha (ESR1) knockout (KO) male mice, we describe a unique SFM whose inhabitants differ from gut microbes. The bacterial composition of the SFM is influenced according to whether mice have functional Esr1 genes. Propionibacterium acnes, causative agent of chronic prostatitis possibly culminating in prostate cancer, is reduced in SFM of ESR1 KO compared to WT mice (P ≤ 0.0007). In certain genetic backgrounds, WT mice show a greater incidence of prostate cancer than ESR1 KO, which may be due to increased abundance of P. acnes. Additionally, select gut microbiome residents in ESR1 KO males, such as Lachnospiraceae and Christensenellaceae, might contribute to previously identified phenotypes, especially obesity, in these mutant mice. Understanding how genetics and environmental factors influence the SFM may provide the next frontier in male reproductive disorders and possibly paternal-based DOHaD diseases.

Sign in / Sign up

Export Citation Format

Share Document