Influence of sodium pyrophosphate on the physicochemical and gelling properties of myofibrillar proteins under hydroxyl radical-induced oxidative stress

2020 ◽  
Vol 11 (3) ◽  
pp. 1996-2004 ◽  
Author(s):  
Yungang Cao ◽  
Wenhui Ma ◽  
Jiankang Wang ◽  
Shuhua Zhang ◽  
Zhenyu Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hydroxyl Radical ◽  
Rheological Behavior ◽  
Sodium Pyrophosphate ◽  
Myofibrillar Proteins ◽  
Gelling Properties

Sodium pyrophosphate (PP) addition changed the rheological behavior and improved the gelling properties of oxidative stressed myofibrillar proteins (MP).

scholarly journals The effect of fibrin on rheological behavior, gelling properties and microstructure of myofibrillar proteins

LWT ◽  
2022 ◽  
Vol 153 ◽  
pp. 112457
Author(s):  
Juanjuan Du ◽  
Changyu Zhou ◽  
Qiang Xia ◽  
Ying Wang ◽  
Fang Geng ◽  
...  
Keyword(s):  
Rheological Behavior ◽  
Myofibrillar Proteins ◽  
Gelling Properties

Effect of hydroxyl radical induced oxidation on the physicochemical and gelling properties of shrimp myofibrillar protein and its mechanism

2021 ◽  
Vol 351 ◽  
pp. 129344
Author(s):  
De-Yang Li ◽  
Zhi-Feng Tan ◽  
Zi-Qiang Liu ◽  
Chao Wu ◽  
Hui-Lin Liu ◽  
...  
Keyword(s):  
Hydroxyl Radical ◽  
Myofibrillar Protein ◽  
Gelling Properties

Fenton-like reaction of iron(II)-histidine complex generates hydroxyl radical: implications for oxidative stress and Alzheimer's disease

2021 ◽  
Author(s):  
Can Wang ◽  
Zheng Wang ◽  
Binglin Zeng ◽  
Meiqing Zheng ◽  
Nao Xiao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Hydroxyl Radical ◽  
Common Understanding

The hydroxyl radical (•OH), generated from Fenton/Fenton-like reactions of iron(II) species in biology, can oxidatively damage biomolecules, inducing oxidative stress and diseases. However, this common understanding has been questioned recently...

Physicochemical changes of myofibrillar proteins of squid (Argentinus ilex) induced by hydroxyl radical generating system

2019 ◽  
Vol 297 ◽  
pp. 124941 ◽  
Author(s):  
Bhoke Marwa Nyaisaba ◽  
Shaimaa Hatab ◽  
Xinxin Liu ◽  
Yu Chen ◽  
Xuhuan Chen ◽  
...  
Keyword(s):  
Hydroxyl Radical ◽  
Myofibrillar Proteins ◽  
Physicochemical Changes ◽  
Generating System

Induction of Gamma-Glutamyltransferase Activity and Consequent Pro-oxidant Reactions in Human Macrophages Exposed to Crocidolite Asbestos

2019 ◽  
Vol 177 (2) ◽  
pp. 476-482 ◽  
Author(s):  
Alessandro Corti ◽  
Justine Bonetti ◽  
Silvia Dominici ◽  
Simona Piaggi ◽  
Vanna Fierabracci ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hydroxyl Radical ◽  
Fenton Reaction ◽  
Redox Cycling ◽  
Pathogenic Potential ◽  
Gamma Glutamyltransferase ◽  
Reduction Of Iron ◽  
Healthy Donors ◽  
Iron Redox

Abstract Asbestos is the main causative agent of malignant pleural mesothelioma. The variety known as crocidolite (blue asbestos) owns the highest pathogenic potential, due to the dimensions of its fibers as well as to its content of iron. The latter can in fact react with macrophage-derived hydrogen peroxide in the so called Fenton reaction, giving rise to highly reactive and mutagenic hydroxyl radical. On the other hand, hydroxyl radical can as well originate after thiol-dependent reduction of iron, a process capable of starting its redox cycling. Previous studies showed that glutathione (GSH) is one such thiol, and that cellular gamma-glutamyltransferase (GGT) can efficiently potentiate GSH-dependent iron redox cycling and consequent oxidative stress. As GGT is expressed in macrophages and is released upon their activation, the present study was aimed at verifying the hypothesis that GSH/GGT-dependent redox reactions may participate in the oxidative stress following the activation of macrophages induced by crocidolite asbestos. Experiments in acellular systems confirmed that GGT-mediated metabolism of GSH can potentiate crocidolite-dependent production of superoxide anion, through the production of highly reactive dipeptide thiol cysteinyl-glycine. Cultured THP-1 macrophagic cells, as well as isolated monocytes obtained from healthy donors and differentiated to macrophages in vitro, were investigated as to their expression of GGT and the effects of exposure to crocidolite. The results show that crocidolite asbestos at subtoxic concentrations (50–250 ng/1000 cells) can upregulate GGT expression, which raises the possibility that macrophage-initiated, GSH/GGT-dependent pro-oxidant reactions may participate in the pathogenesis of tissue damage and inflammation consequent to crocidolite intoxication.

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