A comparative study between Chinese propolis and Brazilian green propolis: metabolite profile and bioactivity

2020 ◽  
Vol 11 (3) ◽  
pp. 2368-2379 ◽  
Author(s):  
Min Yuan ◽  
Xu-jiang Yuan ◽  
Miguel Pineda ◽  
Ze-yu Liang ◽  
Jian He ◽  
...  

A comparative study between Chinese propolis and Brazilian green propolis showed that they have a distinct chemome but similar antioxidant and anti-inflammatory potential.

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Ewelina Szliszka ◽  
Anna Mertas ◽  
Zenon P. Czuba ◽  
Wojciech Król

Artepillin C (3,5-diprenyl-4-hydroxycinnamic acid) is the main bioactive component of Brazilian green propolis. The aim of this study was to investigate the anti-inflammatory effect of artepillin C on LPS + IFN-γ- or PMA-stimulated RAW264.7 macrophages. The cell viability was evaluated by MTT and LDH assays. The radical scavenging ability was determined using DPPH•and ABTS•+. ROS and RNS generation was analyzed by chemiluminescence. NO concentration was detected by the Griess reaction. The release of various cytokines by activated RAW264.7 cells was measured in the culture supernatants using a multiplex bead array system based on xMAP technology. NF-κB activity was confirmed by the ELISA-based TransAM NF-κB kit. At the tested concentrations, the compound did not decrease the cell viability and did not cause the cytotoxicity. Artepillin C exerted strong antioxidant activity, significantly inhibited the production of ROS, RNS, NO, and cytokine IL-1β, IL-3, IL-4, IL-5, IL-9, IL-12p40, IL-13, IL-17, TNF-α, G-CSF, GM-CSF, MCP-1, MIP-1α, MIP-1β, RANTES, and KC, and markedly blocked NF-κB expression in stimulated RAW264.7 macrophages. Our findings provide new insights for understanding the mechanism involved in the anti-inflammatory effect of artepillin C and support the application of Brazilian green propolis in complementary and alternative medicine.


Author(s):  
OJS Admin

Ketoprofen belongs to non-steroidal anti-inflammatory drug which has better results in pain management with combination of steroid and anesthetic drug. In this study compression of two combination had been observed.


Author(s):  
Amit Kumar Jha ◽  
Amit Kumar Jha

Various exogenous and endogenous stimuli incite a complex reaction in vascularized connective tissue called inflammation. Non sterodial antiinflammatory drugs are used to reduce inflammation Preferential COX-2 inhibitors namely diclofenac and aceclofenac was taken for my present work and anti inflammatory effect was compared with control and with each other. Student-t-test-was done to compare result. It was found that inflammation varied significantly across the three groups (P=000) compared to control, in~lammation was less in both diclofenac and aceclofenac (P=00). Reduction of inflammation with diclofenac was less, in comparision to aceclofenac at end. Aceclofenac is more efficacious than diclofenac. Keywords: Aceclofenac, diclofenac, Anti inflammatory effect


2020 ◽  
Vol 16 (67) ◽  
pp. 183
Author(s):  
Eunson Hwang ◽  
Tae-Hoo Yi ◽  
Jung-Eun Yang ◽  
SulWoong Park ◽  
HienT T. Ngo ◽  
...  

2017 ◽  
Vol 32 (22) ◽  
pp. 2740-2744 ◽  
Author(s):  
M. Meera ◽  
A. Ruckmani ◽  
R. Saravanan ◽  
R. Lakshmipathy prabhu

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