Green tea polyphenols prevent lipopolysaccharide-induced inflammatory liver injury in mice by inhibiting NLRP3 inflammasome activation

2019 ◽  
Vol 10 (7) ◽  
pp. 3898-3908 ◽  
Author(s):  
Dongxu Wang ◽  
Man Zhang ◽  
Taotao Wang ◽  
Min Cai ◽  
Frank Qian ◽  
...  
Keyword(s):  
Public Health ◽  
Liver Injury ◽  
Green Tea ◽  
Liver Diseases ◽  
Public Health Problem ◽  
Green Tea Polyphenols ◽  
Inflammasome Activation ◽  
Nlrp3 Inflammasome Activation ◽  
Significant Public Health Problem ◽  
Significant Public Health

Inflammatory liver diseases present a significant public health problem.

scholarly journals Sero-evaluation of Immune Responses to Vibrio cholerae in a Postelimination Setting

2020 ◽  
Vol 7 (5) ◽  
Author(s):  
Tai The Diep ◽  
Owen Jensen ◽  
Nguyen Van Thuong ◽  
Nguyen Thi Ngoc Nhi ◽  
Nguyen Ngoc Anh Thu ◽  
...  
Keyword(s):  
Public Health ◽  
Immune Responses ◽  
Specific Antibody ◽  
Public Health Problem ◽  
Antibody Testing ◽  
Southern Vietnam ◽  
Significant Public Health Problem ◽  
Significant Public Health ◽  
Clinical Surveillance ◽  
Blood Spot

Abstract Cholera remains a significant public health problem worldwide. In settings of declining incidence, serosurveillance may be used to augment clinical surveillance. We utilized dried blood spot sampling and cholera-specific antibody testing to examine the serologic profiles of vaccinated and unvaccinated children in southern Vietnam, where cholera was recently eliminated.

scholarly journals Patient Perception of Ideal Body Weight and the Effect of Body Mass Index

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Rozhin Naghshizadian ◽  
Amir A. Rahnemai-Azar ◽  
Kruthi Kella ◽  
Michael M. Weber ◽  
Marius L. Calin ◽  
...  
Keyword(s):  
Public Health ◽  
Body Weight ◽  
Public Health Problem ◽  
Ideal Body Weight ◽  
Contributing Factors ◽  
Education Of Patients ◽  
Significant Public Health Problem ◽  
Significant Public Health ◽  
Ideal Body ◽  
Obesity Prevention Programs

Objective. Despite much effort, obesity remains a significant public health problem. One of the main contributing factors is patients’ perception of their target ideal body weight. This study aimed to assess this perception.Methods. The study took place in an urban area, with the majority of participants in the study being Hispanic (65.7%) or African-American (28.0%). Patients presented to an outpatient clinic were surveyed regarding their ideal body weight and their ideal BMI calculated. Subsequently they were classified into different categories based on their actual measured BMI. Their responses for ideal BMI were compared.Results. In 254 surveys, mean measured BMI was 31.71 ± 8.01. Responses to ideal BMI had a range of 18.89–38.15 with a mean of 25.96 ± 3.25. Mean (±SD) ideal BMI for patients with a measured BMI of <18.5, 18.5–24.9, 25–29.9, and ≥30 was 20.14 ± 1.46, 23.11 ± 1.68, 25.69 ± 2.19, and 27.22 ± 3.31, respectively. These differences were highly significant (P<0.001, ANOVA).Conclusions. Most patients had an inflated sense of their target ideal body weight. Patients with higher measured BMI had higher target numbers for their ideal BMI. Better education of patients is critical for obesity prevention programs.

scholarly journals Arthritis and Benznidazole: More Closely Related than We Thought

2014 ◽  
Vol 59 (1) ◽  
pp. 727-729 ◽  
Author(s):  
E. Aldasoro ◽  
M. J. Pinazo ◽  
I. Oliveira ◽  
J. Munoz ◽  
E. Posada ◽  
...  
Keyword(s):  
Public Health ◽  
Chagas Disease ◽  
Health Problem ◽  
Parasitic Infection ◽  
Public Health Problem ◽  
Drug Reactions ◽  
Content Type ◽  
Significant Public Health Problem ◽  
Rare Side Effect ◽  
Significant Public Health

ABSTRACTChagas disease is a parasitic infection that leads to a significant public health problem in countries where the disease is endemic and where it is nonendemic. Benznidazole is the most commonly used drug for the etiological treatment of Chagas disease. Patients treated with benznidazole suffer frequent adverse drug reactions. Although arthralgia is common, arthritis has been reported as a very rare side effect. The objective of this study was to describe arthritis in a cohort ofTrypanosoma cruzi-infected patients treated with benznidazole.

Superwarfarin poisoning: A significant public health problem

1994 ◽  
Vol 19 (1) ◽  
pp. 55-65 ◽  
Author(s):  
Alan E. Rauch ◽  
Richard Weininger ◽  
Donald Pasquale ◽  
Peter T. Burkart ◽  
Harry G. Dunn ◽  
...  
Keyword(s):  
Public Health ◽  
Health Problem ◽  
Public Health Problem ◽  
Significant Public Health Problem ◽  
Significant Public Health

scholarly journals What about the other 50 percent of the Canadian population? Food allergies ignored in national policy plan

2018 ◽  
Vol 5 (3) ◽  
pp. 285-289
Author(s):  
Susan Elliott ◽  
Francesca Cardwell
Keyword(s):  
Public Health ◽  
Food Allergy ◽  
Research Policy ◽  
National Policy ◽  
Public Health Problem ◽  
Food Allergies ◽  
Canadian Population ◽  
Significant Public Health Problem ◽  
Significant Public Health

Food allergy is a growing public health epidemic in Canada, affecting 50 percent of Canadian households either directly or indirectly. Despite the physical, psychosocial and quality of life impacts to those affected, food allergy has recently been ignored in the Canadian policy context. While the complete etiology of food allergy remains unknown, we have enough information to make strong policy choices that can maximize choice and minimize risk for affected Canadians, and place Canada at the forefront of food allergy management and research. Policy recognizing food allergy as a chronic health issue that represents a significant public health problem in Canada is critical.

scholarly journals Editorial: A Review of Micronutrients and the Immune System—Working in Harmony to Reduce the Risk of Infection

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 4180
Author(s):  
Ascensión Marcos
Keyword(s):  
Public Health ◽  
Immune System ◽  
Health Problem ◽  
Public Health Problem ◽  
Risk Of Infection ◽  
Recent Memory ◽  
Significant Public Health Problem ◽  
Significant Public Health

The emergence of the SARS-CoV virus in December 2019 saw the beginning of an unprecedented pandemic that represents the most significant public health problem in recent memory [...]

scholarly journals Seroprevalence of antibodies toRickettsia typhiin the Waikato region of New Zealand

2016 ◽  
Vol 144 (11) ◽  
pp. 2283-2289 ◽  
Author(s):  
M. Y. LIM ◽  
P. WEINSTEIN ◽  
A. BELL ◽  
T. HAMBLING ◽  
D. M. TOMPKINS ◽  
...  
Keyword(s):  
Public Health ◽  
New Zealand ◽  
Public Health Problem ◽  
Health Interventions ◽  
Murine Typhus ◽  
Rickettsia Felis ◽  
Significant Difference ◽  
Significant Public Health Problem ◽  
Significant Public Health ◽  
Human Sera

SUMMARYThe first reported New Zealand-acquired case of murine typhus occurred near Auckland in 1989. Since then, 72 locally acquired cases have been recorded from northern New Zealand. By 2008, on the basis of the timing and distribution of cases, it appeared that murine typhus was escalating and spreading southwards. To explore the presence ofRickettsia typhiin the Waikato region, we conducted a seroprevalence study, using indirect immunofluorescence, Western blot, and cross-adsorption assays of blood donor samples. Of 950 human sera from Waikato, 12 (1·3%) hadR. typhiantibodies. The seroprevalence forR. typhiwas slightly higher in northern Waikato (1·4%) compared to the south (1·2%; no significant difference,χ2P= 0·768 atP< 0·05). Our results extend the reported southern range ofR. typhiby 140 km and indicate it is endemic in Waikato. Evidence of pastRickettsia felisinfections was also detected in six sera. Globally,R. felisis an emerging disease of concern and this pathogen should also be considered when locally acquired rickettsiosis is suspected. If public health interventions are to be implemented to reduce the risk of rickettsioses as a significant public health problem, improvements in rickettsial diagnostics and surveillance will be necessary.

scholarly journals Baclofen in the short-term maintenance treatment of benzodiazepine dependence

2014 ◽  
Vol 05 (S 01) ◽  
pp. S053-S054 ◽  
Author(s):  
Lekhansh Shukla ◽  
Arun Kandasamy ◽  
Muralidharan Kesavan ◽  
Vivek Benegal
Keyword(s):  
Public Health ◽  
Gaba Receptor ◽  
Maintenance Treatment ◽  
Public Health Problem ◽  
Short Term ◽  
Significant Public Health Problem ◽  
Significant Public Health ◽  
Benzodiazepine Dependence ◽  
Term Maintenance

ABSTRACTBenzodiazepine (BZD) dependence is a significant public health problem. Apart from the long-term tapering doses of BZD, no others drugs are available for the maintenance treatment of BZD dependence. Baclofen has been used in alcohol and other drug dependence as long-term anti-craving agent. Since alcohol and BZD act through the GABA receptor, we attempted to study the effect of Baclofen as maintenance treatment in a series of five cases with BZD dependence.

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