Branched mannans from the mushroom Cantharellus cibarius enhance the anticancer activity of natural killer cells against human cancers of lung and colon

2019 ◽  
Vol 10 (9) ◽  
pp. 5816-5826 ◽  
Author(s):  
Marta K. Lemieszek ◽  
Fernando M. Nunes ◽  
Wojciech Rzeski
Keyword(s):  
Colon Cancer ◽  
Natural Killer Cells ◽  
Epithelial Cells ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Natural Killer ◽  
Colon Cancer Cells ◽  
Killer Cells ◽  
Human Cancers

Cantharellus cibarius branched mannans increase natural killer cells NK92 viability and proliferation and enhance their cytotoxicity against lung and colon cancer cells A549 and LS180, at the same time they do not affect lung and colon epithelial cells NL20 and CCD841 CoN.

scholarly journals Ultrasound-enhanced biosynthesis of uniform ZnO nanorice using Swietenia macrophylla seed extract and its in vitro anticancer activity

2021 ◽  
Vol 10 (1) ◽  
pp. 572-585
Author(s):  
Darren Yi Sern Low ◽  
Camille Keisha Mahendra ◽  
Janarthanan Supramaniam ◽  
Loh Teng Hern Tan ◽  
Learn Han Lee ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Hexagonal Wurtzite Structure ◽  
Colon Cancer Cells ◽  
Swietenia Macrophylla ◽  
Zno Nps ◽  
Human Colon Cancer ◽  
Hct 116

Abstract In this study, ultrasonically driven biosynthesis of zinc oxide nanoparticles (ZnO NPs) using Swietenia macrophylla seed ethyl acetate fraction (SMEAF) has been reported. X-ray powder diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR) analyses confirmed the presence of a pure hexagonal wurtzite structure of ZnO. Field emission scanning electron microscope images revealed the formation of uniquely identifiable uniform rice-shaped biologically synthesized ZnOSMEAF particles. The particle sizes of the biosynthesized NPs ranged from 262 to 311 nm. The underlying mechanisms for the biosynthesis of ZnOSMEAF under ultrasound have been proposed based on FTIR and XRD results. The anticancer activity of the as-prepared ZnOSMEAF was investigated against HCT-116 human colon cancer cell lines via methyl thiazolyl tetrazolium assay. ZnOSMEAF exhibited significant anticancer activity against colon cancer cells with higher potency than ZnO particles prepared using the chemical method and SMEAF alone. Exposure of HCT-116 colon cancer cells to ZnOSMEAF promoted a remarkable reduction in cell viability in all the tested concentrations. This study suggests that green sonochemically induced ZnO NPs using medicinal plant extract could be a potential anticancer agent for biomedical applications.

scholarly journals Immunosurveillance of senescent cancer cells by natural killer cells

2014 ◽  
Vol 3 (2) ◽  
pp. e27616 ◽  
Author(s):  
Alexandre Iannello ◽  
David H Raulet
Keyword(s):  
Natural Killer Cells ◽  
Cancer Cells ◽  
Natural Killer ◽  
Killer Cells

scholarly journals THE INHIBITION OF POLYISOPRENOIDS FROM NYPA FRUTICANS LEAVES ON CYCLOOXYGENASE 2 EXPRESSION OF WIDR COLON CANCER CELLS

2018 ◽  
Vol 11 (8) ◽  
pp. 154 ◽  
Author(s):  
Dini Permata Sari ◽  
Mohammad Basyuni ◽  
Poppy Anjelisa Zaitun Hasibuan ◽  
Ridha Wati
Keyword(s):  
Colon Cancer ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Colon Cancer Cell ◽  
Cyclooxygenase 2 ◽  
Colon Cancer Cells ◽  
Chemopreventive Agents ◽  
Nypa Fruticans ◽  
Diphenyltetrazolium Bromide ◽  
Cox 2

Objective: The objective of the study was to investigate the inhibitory activity of polyisoprenoids from Nypa fruticans leaves on the expression of cyclooxygenase 2 (COX-2) against colon cancer cells.Methods: Anticancer activity performed was tested by dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method on colon cancer cell WiDr. The expression of COX-2 was observed by the immunocytochemistry method.Result: Polyisoprenoids from N. fruticans leaves exhibit anticancer activity on WiDr cells through inhibition of COX-2 expression with IC50 180.186±7.16 μg/ml.Conclusions: This study showed that polyisoprenoids from N. fruticans leaves promise chemopreventive agents for colon cancer through COX-2 inhibition.

Ex vivo-expanded natural killer cells kill cancer cells more effectively than ex vivo-expanded γδ T cells or αβ T cells

2014 ◽  
Vol 22 (2) ◽  
pp. 486-491 ◽  
Author(s):  
Xuewen Deng ◽  
Hiroshi Terunuma ◽  
Atsushi Terunuma ◽  
Tsubasa Takane ◽  
Mie Nieda
Keyword(s):  
T Cells ◽  
Natural Killer Cells ◽  
Cancer Cells ◽  
Natural Killer ◽  
Ex Vivo ◽  
Γδ T Cells ◽  
Killer Cells ◽  
Αβ T Cells

In vitro anticancer activity of new gold(III) porphyrin complexes in colon cancer cells

2017 ◽  
Vol 177 ◽  
pp. 27-38 ◽  
Author(s):  
Fatima Dandash ◽  
David Yannick Léger ◽  
Chloë Fidanzi-Dugas ◽  
Soumaya Nasri ◽  
Frédérique Brégier ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Colon Cancer Cells

Interplay between cancer cells, macrophages and natural killer cells may actually decide the outcome of therapy with sorafenib

Hepatology ◽  
2014 ◽  
Vol 60 (1) ◽  
pp. 430-430 ◽  
Author(s):  
Ciprian Tomuleasa ◽  
Gianluigi Giannelli ◽  
Andrei Cucuianu ◽  
Mihaela Aldea ◽  
Angelo Paradiso ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Cancer Cells ◽  
Natural Killer ◽  
Killer Cells
Sign in / Sign up

Export Citation Format

Share Document