Effect of polysaccharides from adlay seed on anti-diabetic and gut microbiota

2019 ◽  
Vol 10 (7) ◽  
pp. 4372-4380 ◽  
Author(s):  
Li-Chun Chen ◽  
Zhong-Yang Fan ◽  
Hong-Yu Wang ◽  
Dong-Cheng Wen ◽  
Shi-Yu Zhang
Keyword(s):  
Gut Microbiota ◽  
Intestinal Microbiota ◽  
Metabolic Pathways ◽  
Diabetic Mice ◽  
Type 2 Diabetic

The hypoglycemic effects of PAS in type-2 diabetic mice (T2D) may be associated with the regulation of the intestinal microbiota and its metabolic pathways.

scholarly journals Loss of Diurnal Oscillatory Rhythms in Gut Microbiota Correlates with Changes in Circulating Metabolites in Type 2 Diabetic db/db Mice

Nutrients ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 2310 ◽  
Author(s):  
Eleni Beli ◽  
Samantha Prabakaran ◽  
Preethi Krishnan ◽  
Carmella Evans-Molina ◽  
Maria B. Grant
Keyword(s):  
Gut Microbiota ◽  
Metabolic Pathways ◽  
Plasma Metabolites ◽  
Diurnal Changes ◽  
Diabetic Mice ◽  
Night Time ◽  
Temporal Regulation ◽  
Oscillatory Rhythms ◽  
Type 2 Diabetic

Our hypothesis is that diabetes leads to loss of diurnal oscillatory rhythms in gut microbiota altering circulating metabolites. We performed an observational study where we compared diurnal changes of the gut microbiota with temporal changes of plasma metabolites. Metadata analysis from bacterial DNA from fecal pellets collected from 10-month old control (db/m) and type 2 diabetic (db/db) mice every 4 h for a 24-h period was used for prediction analysis. Blood plasma was collected at a day and night time points and was used for untargeted global metabolomic analysis. Feeding and activity behaviors were recorded. Our results show that while diabetic mice exhibited feeding and activity behavior similar to control mice, they exhibited a loss of diurnal oscillations in bacteria of the genus Akkermansia, Bifidobacterium, Allobaculum, Oscillospira and a phase shift in the oscillations of g.Prevotella, proteobacteria, and actinobacteria. Analysis of the circulating metabolites showed alterations in the diurnal pattern of metabolic pathways where bacteria have been implicated, such as the histidine, betaine, and methionine/cysteine pathway, mitochondrial function and the urea cycle. Functional analysis of the differential microbes revealed that during the day, when mice are asleep, the microbes of diabetic mice were enriched in processing carbon and pyruvate metabolic pathways instead of xenobiotic degradation as was observed for control mice. Altogether, our study suggests that diabetes led to loss of rhythmic oscillations of many gut microbiota with possible implications for temporal regulation of host metabolic pathways.

Lactobacillus casei LC89 exert antidiabetic effects through regulating hepatic glucagon response and gut microbiota in type 2 diabetic mice

2021 ◽  
Author(s):  
Yongli Zhang ◽  
Tao Wu ◽  
Wen Li ◽  
Yunjiao Zhao ◽  
Hairong Long ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Molecular Mechanism ◽  
Lactobacillus Casei ◽  
Diabetic Mice ◽  
Antihyperglycemic Activity ◽  
Underlying Mechanisms ◽  
Type 2 Diabetic ◽  
Antidiabetic Effects

Previous study suggests Lactobacillus casei exhibit antihyperglycemic activity, however, the molecular mechanism has rarely been elucidated. Here, the anti-diabetic effects and underlying mechanisms of Lactobacillus casei LC89 were investigated in...

scholarly journals Beneficial Effects of Potentilla discolor Bunge Water Extract on Inflammatory Cytokines Release and Gut Microbiota in High-Fat Diet and Streptozotocin-Induced Type 2 Diabetic Mice

Nutrients ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 670 ◽  
Author(s):  
Lihua Han ◽  
Tiange Li ◽  
Min Du ◽  
Rui Chang ◽  
Biyuan Zhan ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Inflammatory Cytokines ◽  
High Fat Diet ◽  
Intestinal Inflammation ◽  
Water Extract ◽  
Perennial Herb ◽  
Diabetic Mice ◽  
High Fat ◽  
Type 2 Diabetic

Potentilla discolor Bunge (PDB), a perennial herb, has been used as a traditional Chinese medicine in the therapy of many diseases. The aim of the current study was to investigate the effect of PDB water extract on systemic inflammation and gut microbiota in type 2 diabetic (T2D) mice induced by high-fat diet (HFD) and streptozotocin (STZ) injection. C57BL/6J mice were randomly divided into a normal diet (ND) group, T2D group, and PDB group (diabetic mice treated with PDB water extract at a dose of 400 mg/kg body weight). Results showed that PDB significantly decreased the levels of lipopolysaccharide (LPS) and pro-inflammatory cytokines in serum. Further investigation showed that PDB significantly reduced the ratio of Firmicutes/Bacteroidetes and the relative abundance of Proteobacteria in fecal samples of diabetic mice. In addition, PDB notably alleviated intestinal inflammation as evidenced by decreased expression of toll-like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88), nuclear factor-κB (NF-κB), and inflammatory cytokines. PDB also reversed the decreased expression of intestinal mucosal tight junction proteins including Claudin3, ZO-1, and Occludin. Meanwhile, the levels of fecal acetic acid and butyric acid and their specific receptors including G-protein-coupled receptor (GPR) 41 and 43 expression in the colon were also increased after PDB treatment. Our results indicated that PDB might serve as a potential functional ingredient against diabetes and related inflammation.

Oil tea improves glucose and lipid levels and alters gut microbiota in type 2 diabetic mice

2018 ◽  
Vol 57 ◽  
pp. 67-77 ◽  
Author(s):  
Rui Lin ◽  
Xuan He ◽  
Huafeng Chen ◽  
Qin He ◽  
Ziting Yao ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Diabetic Mice ◽  
Lipid Levels ◽  
Type 2 Diabetic

scholarly journals Beneficial effects of polysaccharide-rich extracts from Apocynum venetum leaves on hypoglycemic and gut microbiota in type 2 diabetic mice

2020 ◽  
Vol 127 ◽  
pp. 110182 ◽  
Author(s):  
Yuan Yuan ◽  
Jinhui Zhou ◽  
Yanfen Zheng ◽  
Zongchang Xu ◽  
Yiqiang Li ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Diabetic Mice ◽  
Beneficial Effects ◽  
Apocynum Venetum ◽  
Type 2 Diabetic

Exercise training modifies gut microbiota in normal and diabetic mice

2015 ◽  
Vol 40 (7) ◽  
pp. 749-752 ◽  
Author(s):  
Jennifer E. Lambert ◽  
Jason P. Myslicki ◽  
Marc R. Bomhof ◽  
Darrell D. Belke ◽  
Jane Shearer ◽  
...  
Keyword(s):  
Exercise Training ◽  
Gut Microbiota ◽  
Diabetic Mice ◽  
Qpcr Analysis ◽  
Main Effect ◽  
Exercise Activity ◽  
Cecal Microbiota ◽  
And Control ◽  
Type 2 Diabetic

Cecal microbiota from type 2 diabetic (db/db) and control (db/+) mice was obtained following 6 weeks of sedentary or exercise activity. qPCR analysis revealed a main effect of exercise, with greater abundance of select Firmicutes species and lower Bacteroides/Prevotella spp. in both normal and diabetic exercised mice compared with sedentary counterparts. Conversely, Bifidobacterium spp. was greater in exercised normal but not diabetic mice (exercise × diabetes interaction). How exercise influences gut microbiota requires further investigation.

scholarly journals A Specific Gut Microbiota Dysbiosis of Type 2 Diabetic Mice Induces GLP-1 Resistance through an Enteric NO-Dependent and Gut-Brain Axis Mechanism

2017 ◽  
Vol 25 (5) ◽  
pp. 1075-1090.e5 ◽  
Author(s):  
Estelle Grasset ◽  
Anthony Puel ◽  
Julie Charpentier ◽  
Xavier Collet ◽  
Jeffrey E. Christensen ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Diabetic Mice ◽  
Type 2 Diabetic ◽  
Gut Microbiota Dysbiosis
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