Is sulfidation a true detoxification process for silver nanoparticles?: from the perspective of chronic exposure

2019 ◽  
Vol 6 (12) ◽  
pp. 3611-3624 ◽  
Author(s):  
Mingzhu Li ◽  
Jing Li ◽  
Jing Sun ◽  
Yuning He ◽  
Pengjia Chen ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Acute Toxicity ◽  
Chronic Exposure ◽  
Term Effect ◽  
Long Term Effect ◽  
Detoxification Process

Sulfidation of silver nanoparticles may camouflage its long term effect with imperceptible acute toxicity.

scholarly journals Proton Pump Inhibitors Accelerate Endothelial Senescence

2016 ◽  
Vol 118 (12) ◽  
Author(s):  
Gautham Yepuri ◽  
Roman Sukhovershin ◽  
Timo Z. Nazari-Shafti ◽  
Michael Petrascheck ◽  
Yohannes T. Ghebre ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Chronic Exposure ◽  
Vascular Dysfunction ◽  
Term Effect ◽  
Long Term Effect ◽  
Increased Risk ◽  
Neurological Morbidity

Rationale: Proton pump inhibitors (PPIs) are popular drugs for gastroesophageal reflux, which are now available for long-term use without medical supervision. Recent reports suggest that PPI use is associated with cardiovascular, renal, and neurological morbidity. Objective: To study the long-term effect of PPIs on endothelial dysfunction and senescence and investigate the mechanism involved in PPI-induced vascular dysfunction. Methods and Results: Chronic exposure to PPIs impaired endothelial function and accelerated human endothelial senescence by reducing telomere length. Conclusions: Our data may provide a unifying mechanism for the association of PPI use with increased risk of cardiovascular, renal, and neurological morbidity and mortality.

scholarly journals Does Long-Term Use of Silver Nanoparticles Have Persistent Inhibitory Effect onH. pyloriBased on Mongolian Gerbil’s Model?

2014 ◽  
Vol 2014 ◽  
pp. 1-7
Author(s):  
Chao-Hung Kuo ◽  
Chien-Yu Lu ◽  
Yuan-Chieh Yang ◽  
Chieh Chin ◽  
Bi-Chuang Weng ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Inhibitory Effect ◽  
Term Effect ◽  
Increasing Failure Rate ◽  
Long Term Effect ◽  
Sydney System ◽  
H Pylori

Background. It is urgent to find alternative agents due to increasing failure rate ofHelicobacter pylori (H. pylori) eradication. The study surveyed the long-term effect of silver nanoparticles (AgNP) onH. pyloribased on Mongolian gerbil’s model.Materials and Methods. Fifty gerbils were randomly allocated to six groups (A–F). Group (Gr) A: the gerbils were fed with broth; Gr B and D: the gerbils were fed with AgNP/clay complex (0.1% of weight); Gr C and E: the gerbils were fed with AgNP/clay complex(1% of weight); and Gr D, E, and F: the gerbils were inoculated withH. pylori. At the 20th experimental week, the gerbils were sacrificed. Histology was evaluated according to the classification of the Sydney system.P<0.05was considered to be statistically significant.Results. The AgNP/clay has more obvious inhibitory effect onH. pyloriin vitro. There was a trend of higher concentrations of AgNP with stronger inhibitory effect onH. pylorigrowth(P=0.071). There were no significant differences of inflammation among groups D, E, and F(P=0.688).Conclusion. AgNP/clay would be a potential and safe agent for inhibitingH. pylori. It should be helpful for eradication ofH. pyloriinfection.

A long-term effect of subliminally presented words

2010 ◽  
Author(s):  
Andreas T. Breuer ◽  
Michael E. J. Masson ◽  
Glen E. Bodner
Keyword(s):  
Term Effect ◽  
Long Term Effect
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