Binding and activity of polybrominated diphenyl ether sulfates to thyroid hormone transport proteins and nuclear receptors

2019 ◽  
Vol 21 (6) ◽  
pp. 950-956 ◽  
Author(s):  
Wei-Ping Qin ◽  
Chuan-Hai Li ◽  
Liang-Hong Guo ◽  
Xiao-Min Ren ◽  
Jian-Qing Zhang
Keyword(s):  
Thyroid Hormone ◽  
Nuclear Receptors ◽  
Phase Ii ◽  
Polybrominated Diphenyl Ethers ◽  
Diphenyl Ether ◽  
Transport Proteins ◽  
Hormone Transport ◽  
System P ◽  
Diphenyl Ethers ◽  
Phase Ii Metabolites

Polybrominated diphenyl ethers sulfates (PBED sulfates), phase-II metabolites of hydroxylated PBDEs (OH-PBDEs), play important roles in their disruption effects on the thyroid hormone (TH) system.

scholarly journals Exposure to Polybrominated Diphenyl Ethers (PBDEs) and Hypothyroidism in Canadian Women

2016 ◽  
Vol 101 (2) ◽  
pp. 590-598 ◽  
Author(s):  
Youssef Oulhote ◽  
Jonathan Chevrier ◽  
Maryse F. Bouchard
Keyword(s):  
Thyroid Hormone ◽  
Polybrominated Diphenyl Ethers ◽  
Diphenyl Ether ◽  
Hormone Replacement ◽  
Plasma Concentrations ◽  
Reproductive Age ◽  
Age Group ◽  
Cross Sectional ◽  
Wide Range ◽  
Diphenyl Ethers

Context: Polybrominated diphenyl ethers (PBDEs) are used as flame retardants in a wide range of products, resulting in widespread human exposure. Epidemiological studies in some populations reported exposure to PBDEs and thyroid hormone levels but little epidemiological data are available among women from the general population. Objective: The objective of the study was to examine the association of PBDEs with hypothyroidism. Design and Setting: This was a cross-sectional analysis of the 2007–2009 Canadian Health Measures Survey. Participants: A total of 745 women representative of Canadian women aged 30–79 years participated in the study. Main Outcome and Methods: We estimated the prevalence ratios (PRs) for hypothyroidism in relation to plasma concentrations of BDE-47, -99, -100, and -153 and their sum (ΣPBDEs). Women were identified as cases if they reported a doctor-diagnosed thyroid condition and underwent thyroid hormone replacement therapy (n = 90). Results: Higher plasma levels of brominated diphenyl ether (BDE)-47 and -100 and ΣPBDEs were associated with an increased prevalence of hypothyroidism. The PR for a 10-fold increase in ΣPBDEs was 1.7 (95% confidence interval [CI] 1.0, 3.0). Associations were consistently higher among women aged 30–50 years than among those 51–79 years for ΣPBDEs and the other PBDE congeners, although the interaction was significant only for BDE-100. For instance, in the younger age group, women with detectable levels of BDE-100 had a PR of 3.8 (95% CI 1.2, 12.3) compared with women with undetectable levels; the corresponding PR in the older age group was 1.2 (95% CI 0.6, 2.3). No association was observed for BDE-99 and -153. Conclusion: Plasma PBDE levels were associated with an increased prevalence of hypothyroidism in Canadian women aged 30–50 years. Although the cross-sectional design of the study limits inferences of causality, these findings have important implications, given the key role of thyroid hormones in several biological mechanisms during reproductive age.

Polybrominated diphenyl ethers and thyroid hormone homeostasis in a New England cohort

2013 ◽  
Vol 2013 (1) ◽  
pp. 5180
Author(s):  
Colleen Makey ◽  
Michael McClean ◽  
Lewis Braverman ◽  
Elizabeth Pearce ◽  
Janice Weinberg ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
New England ◽  
Polybrominated Diphenyl Ethers ◽  
Diphenyl Ethers ◽  
Hormone Homeostasis

Photodegradation of 2,4,4′-tribrominated diphenyl ether in various surfactant solutions: kinetics, mechanisms and intermediates

2018 ◽  
Vol 20 (5) ◽  
pp. 806-812 ◽  
Author(s):  
Kaibo Huang ◽  
Guining Lu ◽  
Zhiqiang Zheng ◽  
Rui Wang ◽  
Ting Tang ◽  
...  
Keyword(s):  
Polybrominated Diphenyl Ethers ◽  
Diphenyl Ether ◽  
Surfactant Solutions ◽  
Diphenyl Ethers

Currently, photodegradation has been proven to be an important way of eliminating polybrominated diphenyl ethers (PBDEs) from the environment.

Impact of Polybrominated Diphenyl Ethers on Thyroid Hormone Levels Among California Women During Second Trimester of Pregnancy

Epidemiology ◽  
2011 ◽  
Vol 22 ◽  
pp. S161
Author(s):  
Ami Zota ◽  
Jackie Schwartz ◽  
Jody Steinauer ◽  
Myrto Petreas ◽  
Tanya Pasternack ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Polybrominated Diphenyl Ethers ◽  
Second Trimester ◽  
Hormone Levels ◽  
Diphenyl Ethers ◽  
Thyroid Hormone Levels
Sign in / Sign up

Export Citation Format

Share Document