scholarly journals Dendritic silver self-assembly in molten-carbonate membranes for efficient carbon dioxide capture

2020 ◽  
Vol 13 (6) ◽  
pp. 1766-1775 ◽  
Author(s):  
Liam A. McNeil ◽  
Greg A. Mutch ◽  
Francesco Iacoviello ◽  
Josh J. Bailey ◽  
Georgios Triantafyllou ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Self Assembly ◽  
Carbon Dioxide Capture ◽  
Molten Carbonate ◽  
Self Assembling ◽  
Dendritic Networks ◽  
Order Of Magnitude

Self-assembling Ag dendritic networks provide ultrahigh CO2 permeability, whilst reducing membrane-volume-normalised Ag demand by an order of magnitude.

scholarly journals Thiophosphopeptides Instantly Targeting Golgi Apparatus and Selectively Killing Cancer Cells

2021 ◽  
Author(s):  
Weiyi Tan ◽  
Qiuxin Zhang ◽  
Jiaqing Wang ◽  
Meihui Yi ◽  
Hongjian He ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Golgi Apparatus ◽  
Oxygen Atom ◽  
Cancer Cells ◽  
Self Assembly ◽  
Disulfide Bonds ◽  
Unexpected Result ◽  
Subcellular Compartment ◽  
Self Assembling ◽  
Order Of Magnitude

ABSTRACTGolgi apparatus is emerging as a key signaling hub of cells, but there are few approaches for targeting Golgi and selectively killing cancer cells. Here we show an unexpected result that changing an oxygen atom of the phosphoester bond in phospho-peptides by a sulfur atom enables instantly targeting Golgi apparatus (GA) and selectively killing cancer cells by enzymatic self-assembly. Specifically, conjugating cysteamine S-phosphate to the C-terminal of a self-assembling peptide generates a thiophospho-peptide. Being a substrate of alkaline phosphatase (ALP), the thiophosphopeptide undergoes rapid ALP-catalyzed dephosphorylation to form a thiopeptide that self-assembles. The thiophosphopeptide enters cells via caveolin-mediated endocytosis and macropinocytosis and instantly accumulates in GA because of dephosphorylation and formation of disulfide bonds in Golgi. Moreover, the thiophosphopeptide, targeting Golgi, potently and selectively inhibits cancer cells (e.g., HeLa) with the IC50 (about 3 μM), which is an order of magnitude more potent than that of the parent phosphopeptide. This work, as the first report of thiophospho-peptide for targeting Golgi, illustrates a new molecular platform for designing enzyme responsive molecules that target subcellular compartment for functions.

Factors Affecting Molecular Self-Assembly and Its Mechanism

2012 ◽  
Vol 9 (1) ◽  
pp. 43 ◽  
Author(s):  
Hueyling Tan
Keyword(s):  
Self Assembly ◽  
Building Blocks ◽  
Molecular Engineering ◽  
Molecular Structures ◽  
Polymer Science ◽  
New Approach ◽  
Factors Affecting ◽  
Dna Structures ◽  
Self Assembling ◽  
Wide Range

Molecular self-assembly is ubiquitous in nature and has emerged as a new approach to produce new materials in chemistry, engineering, nanotechnology, polymer science and materials. Molecular self-assembly has been attracting increasing interest from the scientific community in recent years due to its importance in understanding biology and a variety of diseases at the molecular level. In the last few years, considerable advances have been made in the use ofpeptides as building blocks to produce biological materials for wide range of applications, including fabricating novel supra-molecular structures and scaffolding for tissue repair. The study ofbiological self-assembly systems represents a significant advancement in molecular engineering and is a rapidly growing scientific and engineering field that crosses the boundaries ofexisting disciplines. Many self-assembling systems are rangefrom bi- andtri-block copolymers to DNA structures as well as simple and complex proteins andpeptides. The ultimate goal is to harness molecular self-assembly such that design andcontrol ofbottom-up processes is achieved thereby enabling exploitation of structures developed at the meso- and macro-scopic scale for the purposes oflife and non-life science applications. Such aspirations can be achievedthrough understanding thefundamental principles behind the selforganisation and self-synthesis processes exhibited by biological systems.

Sign in / Sign up

Export Citation Format

Share Document