A general benzylic C–H activation and C–C coupling reaction of zirconocenes mediated by C–N bond cleavage in tert-butylisocyanide – unusual formation of iminoacyl complexes

2019 ◽  
Vol 48 (44) ◽  
pp. 16525-16533
Author(s):  
Perdita Arndt ◽  
Melanie Reiß ◽  
Anke Spannenberg ◽  
Claas Schünemann ◽  
Fabian Reiß ◽  
...  
Keyword(s):  
Bond Cleavage ◽  
Coupling Reaction ◽  
Unusual Formation

Reactions of the zirconocene alkyne complex [rac-(ebthi)Zr(η2-Me3SiC2SiMe3)] (rac-(ebthi) = rac-1,2-ethylene-1,1′-bis(η5-tetrahydroindenyl)) with tert-butylisocyanide and methylbenzenes were investigated.

Stepwise on-surface synthesis of thiophene-based polymeric ribbon by coupling reaction and carbon-fluorine bond cleavage

2021 ◽  
Author(s):  
Liqian Liu ◽  
Hengqi Zou ◽  
Xinrui Miao ◽  
Hin-Lap Yip ◽  
Wenli Deng ◽  
...  
Keyword(s):  
Bond Cleavage ◽  
Coupling Reaction

The rational synthesis of thiophene-based cross-coupled polymer on surfaces has been attracted more attention recently. Here we report that stepwise activation of 5,5'-(2,3-difluoro-1,4-phenylene)bis(2-bromothiophene) as a precursor to synthesize thiophene-based polymeric...

I2/TBHP-Promoted Approach to α-Keto Esters from Trifluoromethyl β-Diketones and Alcohols via C–C Bond Cleavage

Synlett ◽  
2017 ◽  
Vol 28 (15) ◽  
pp. 2018-2023 ◽  
Author(s):  
Xiang Fang ◽  
Xueyan Yang ◽  
Tongle Shao ◽  
Jun Zhou ◽  
Chen Jin ◽  
...  
Keyword(s):  
Oxidative Coupling ◽  
Bond Cleavage ◽  
Bond Formation ◽  
Coupling Reaction ◽  
Mechanistic Studies ◽  
Metal Free ◽  
Oxidation Pathway ◽  
Keto Esters ◽  
Oxidative Coupling Reaction

A metal-free oxidative coupling reaction of trifluoromethyl β-diketones with alcohols for the synthesis of α-keto esters in good to excellent yields has been developed. Preliminary mechanistic studies suggest that an I2/TBHP promoted sequential iodination, C–C bond cleavage, C–O bond formation and oxidation pathway is involved in this reaction.

Rhodium‐Catalyzed Hiyama Coupling Reaction of Unstrained Ketones via C−C Bond Cleavage

2019 ◽  
Vol 8 (8) ◽  
pp. 1358-1362 ◽  
Author(s):  
Cheng Jiang ◽  
Wen‐Qiang Wu ◽  
Hong Lu ◽  
Tian‐Yang Yu ◽  
Wen‐Hua Xu ◽  
...  
Keyword(s):  
Bond Cleavage ◽  
Coupling Reaction

scholarly journals Organozinc-mediated direct cross-coupling under microwave irradiation

2021 ◽  
pp. 174751982110264
Author(s):  
Chun-Jing Li
Keyword(s):  
Microwave Irradiation ◽  
Functional Group ◽  
Bond Cleavage ◽  
Reaction Times ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Cross Coupling Reaction ◽  
Direct Cross ◽  
Methyl Pyrrolidone ◽  
Work Up

We report a direct cross-coupling reaction between (het)aryl pivalates/tosylates and di(het)arylzinc species in 2-methyltetrahydrofuran/ N-methyl pyrrolidone (1:1), which occurs via C–O bond cleavage under microwave irradiation. The reaction takes place smoothly in short reaction times without the addition of any catalyst or ligand. The reaction is suitable for a broad scope of substrates and exhibits good functional group compatibility, utilizes a simple work-up procedure, and gives the desired products in high purity.

scholarly journals Iodine induced alteration in immunological and biochemical properties of thyroglobulin.

1993 ◽  
Vol 40 (2) ◽  
pp. 237-240 ◽  
Author(s):  
A Gardas ◽  
H Domek
Keyword(s):  
Molecular Mass ◽  
Bond Cleavage ◽  
Coupling Reaction ◽  
Peptide Bond ◽  
Biochemical Properties ◽  
Disulphide Bridge ◽  
Peptide Bond Cleavage ◽  
Epitope Structure ◽  
Iodide Solution ◽  
Ph Dependent

The influence of iodine-iodide solution on the biochemical and immunological properties of human thyroglobulin (hTg) were studied. Human Tg preincubated with the iodine-iodide solution is split to small molecular mass fragments after disulphide bridge reduction with dithiothreitol. The peptide bond cleavage by iodine pretreatment and reduction is possibly linked with the coupling reaction of diiodotyrosyl residues. Pretreatment of hTg with iodine-iodide solution at 1-10 microM decreased the binding of autoantibodies to hTg. The iodine-iodide induced inactivation of hTg autoepitopes is pH dependent and is possibly caused by iodination of tyrosyl residues present in the epitope structure.

Palladium-catalyzed Suzuki cross-couplings of N′-mesyl arylhydrazines via C–N bond cleavage

RSC Advances ◽  
2014 ◽  
Vol 4 (49) ◽  
pp. 25576-25579 ◽  
Author(s):  
He-Ping Zhou ◽  
Jin-Biao Liu ◽  
Jian-Jun Yuan ◽  
Yi-Yuan Peng
Keyword(s):  
Boronic Acid ◽  
Bond Cleavage ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Mild Conditions ◽  
Cross Coupling Reaction ◽  
Palladium Catalyzed ◽  
High Yields ◽  
Aryl Boronic Acid ◽  
Biaryl Compounds

An efficient palladium-catalyzed Suzuki cross-coupling reaction of N′-mesyl arylhydrazine with aryl boronic acid is described, which affords the corresponding biaryl compounds in high yields. This transformation proceeds through C–N bond cleavage under mild conditions.

Zur gezielten Synthese funktionell substituierter Oligosilane aus Silyltriflaten und Aminosilyllithiumverbindungen / Tailor-Made Synthesis of Functional Substituted Oligosilanes from Silyl Triflates and (Aminosilyl)Lithium Compounds

2003 ◽  
Vol 58 (1) ◽  
pp. 183-190 ◽  
Author(s):  
Wolfram Uhlig
Keyword(s):  
Bond Cleavage ◽  
Reaction Times ◽  
Coupling Reaction ◽  
Building Blocks ◽  
Side Reactions ◽  
Coupling Reactions ◽  
Polymer Backbone ◽  
Exchange Processes ◽  
Halogen Exchange ◽  
High Yields

Abstract Diethylamino substituted silyllithium compounds have been prepared in situ from the corresponding phenylchlorosilanes and lithium. These reagents undergo coupling reactions with triflate derivatives of silanes and oligosilanes. Exchange processes analogous to metal halogen exchange and Si-Si bond cleavage, which are side reactions with chlorosilanes, were not observed. Based on the coupling reaction and the amino-to-triflate transformation, functionalized tri-, tetra-, penta- und hexasilanes have been synthesized. α,ω-Triflate substituted oligosilanes containing π-systems have also been obtained. These compounds are useful building blocks for new organosilicon polymers. The formation of the silicon polymers at low temperatures, in short reaction times, and with high yields is reported. The 29Si NMR spectra indicate a regular, alternating arrangement of the building blocks in the polymer backbone.

Iodine-Promoted Synthesis of 4-Aryl-2-(arylsulfonyl)quinolones by Desulfurative C–S Cross-Coupling Reaction of Quinoline-2-thiones with Sodium Sulfinates

Synlett ◽  
2020 ◽  
Vol 31 (15) ◽  
pp. 1527-1531
Author(s):  
Zheng-Jun Quan ◽  
Guo-Chao Yang ◽  
Xi-Chun Wang
Keyword(s):  
Bond Cleavage ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Quinoline Derivatives ◽  
Cross Coupling Reaction

An iodine-induced sulfonylation of quinoline-2-thiones with sodium arenesulfinates as sulfur sources for the synthesis of 4-aryl-2-(arylsulfonyl)quinoline derivatives is described. The 4-aryl-2-(arylsulfonyl)quinoline derivatives can be obtained in a moderate to good yields. This C–S bond cleavage and C–S cross-coupling proceeds in the absence of a metal under inexpensive and nontoxic conditions and it displays a broad substrate scope.

Copper Iodide-Catalyzed Coupling Reaction of Benzofuran-3(2H)-ones with Amines: an Approach to α-Ketoamides

2021 ◽  
Author(s):  
Rongxiang Chen ◽  
Ruo-Ling Jia ◽  
Wenbo Li ◽  
Wei Zhao ◽  
Kai-Kai Wang ◽  
...  
Keyword(s):  
Formation Mechanism ◽  
Bond Cleavage ◽  
Direct Synthesis ◽  
Bond Formation ◽  
Coupling Reaction ◽  
Copper Iodide

A CuI-catalyzed coupling reaction of benzofuran-3(2H)-ones with amines has been well established for the direct synthesis of α-ketoamides. This process involves C–O bond cleavage and C=O/C–N bond formation. Mechanism studies...

Sign in / Sign up

Export Citation Format

Share Document