Ruthenium(ii) and palladium(ii) homo- and heterobimetallic complexes: synthesis, crystal structures, theoretical calculations and biological studies

2019 ◽  
Vol 48 (42) ◽  
pp. 15869-15887 ◽  
Author(s):  
Banafshe Askari ◽  
Hadi Amiri Rudbari ◽  
Nicola Micale ◽  
Tanja Schirmeister ◽  
Thomas Efferth ◽  
...  
Keyword(s):  
Crystal Structures ◽  
Proliferative Activity ◽  
Theoretical Calculations ◽  
Coordination Modes ◽  
Heterobimetallic Complexes ◽  
Biological Studies

Four Ru–Pd heterobimetallic complexes, each one in two different coordination modes (NNSS and NS) were prepared of dialkyldithiooxamidate ligands. All stable NS complexes showed anti-proliferative activity.

Cd(II)/Fe(III) heterobimetallic complexes with dien and cyanido ligands as precursors of ferrite-type oxides: Syntheses, crystal structures, thermal properties and identification of the oxides

Polyhedron ◽  
2021 ◽  
Vol 200 ◽  
pp. 115101
Author(s):  
Miroslava Matiková-Maľarová ◽  
Marek Matik ◽  
Jaroslav Briančin ◽  
Juraj Kuchár ◽  
Zdirad Žák ◽  
...  
Keyword(s):  
Thermal Properties ◽  
Crystal Structures ◽  
Heterobimetallic Complexes

scholarly journals Relation between Crystal Structures of Precursors and Final Products: Example of Vitamin D Intermediates

Molecules ◽  
2020 ◽  
Vol 25 (8) ◽  
pp. 1802
Author(s):  
Monika Wanat ◽  
Maura Malinska ◽  
Andrzej Kutner ◽  
Krzysztof Woźniak
Keyword(s):  
Vitamin D ◽  
Crystal Structures ◽  
Theoretical Calculations ◽  
Geometrical Parameters ◽  
Space Groups ◽  
Vitamin D Analogues ◽  
Vitamin D Analog ◽  
Exocyclic Methylene ◽  
Solid Form ◽  
Methylene Group

In this paper, we proved that the solid-state structure of vitamin D analog is well represented by the structures of its structural fragments. This is important in predicting the biological activity of vitamin D analogs that are not available in the solid form. The previously published crystal structure of advanced vitamin D intermediate provided additional insights into vitamin D properties. A similar analysis based on simple vitamin D intermediate analogues showed that precursors crystallized in the space groups typical for vitamins D; geometrical parameters were related to the corresponding parameters in the vitamin D analogues; and crystal structures of the basic intermediates and their final products contained similar intermolecular interactions, essential for the infinite hydrogen bond motif observed in the vitamin D analogues. The energy of these interactions is related as shown by theoretical calculations, that is, energy frameworks analysis. Moreover, analysis of the hydrogen bonds motifs revealed a relation between these motifs and the absolute configuration of basic intermediates as well as the space orientation of the exocyclic methylene group in the final structures.

Cyanide-bridged polynuclear heterobimetallic complexes: synthesis, crystal structures, and magnetic properties

2019 ◽  
Vol 44 (4) ◽  
pp. 383-389 ◽  
Author(s):  
Wenlong Lan ◽  
Xueting Wang ◽  
Lu Yang ◽  
Weijiang Si ◽  
Shujuan Zhuang ◽  
...  
Keyword(s):  
Magnetic Properties ◽  
Crystal Structures ◽  
Heterobimetallic Complexes

scholarly journals Multilayered stable 2D nano-sheets of Ti2NTx MXene: synthesis, characterization, and anticancer activity

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
A. Szuplewska ◽  
A. Rozmysłowska-Wojciechowska ◽  
S. Poźniak ◽  
T. Wojciechowski ◽  
M. Birowska ◽  
...  
Keyword(s):  
Biological Activity ◽  
Mammary Epithelial Cells ◽  
Theoretical Calculations ◽  
Experimental Studies ◽  
Reactive Oxygen ◽  
Decisive Role ◽  
Max Phase ◽  
Mechanisms Of Toxicity ◽  
Biological Studies

Abstract Background The biological activity of MXenes has been studied for several years because of their potential biomedical applications; however, investigations have so far been limited to 2D titanium carbides. Although monolayered Ti2NTx MXene has been expected to have biological activity, experimental studies revealed significant difficulties due to obstacles to its synthesis, its low stability and its susceptibility to oxidation and decomposition. Results In this paper, we report our theoretical calculations showing the higher likelihood of forming multilayered Ti2NTx structures during the preparation process in comparison to single-layered structures. As a result of our experimental work, we successfully synthesized multilayered Ti2NTx MXene that was suitable for biological studies by the etching of the Ti2AlN MAX phase and further delamination. The biocompatibility of Ti2NTx MXene was evaluated in vitro towards human skin malignant melanoma cells, human immortalized keratinocytes, human breast cancer cells, and normal human mammary epithelial cells. Additionally, the potential mode of action of 2D Ti2NTx was investigated using reactive oxygen tests as well as SEM observations. Our results indicated that multilayered 2D sheets of Ti2NTx showed higher toxicity towards cancerous cell lines in comparison to normal ones. The decrease in cell viabilities was dose-dependent. The generation of reactive oxygen species as well as the internalization of the 2D sheets play a decisive role in the mechanisms of toxicity. Conclusions We have shown that 2D Ti2NTx in the form of multilayered nanoflakes exhibits fair stability and can be used for in vitro studies. These results show promise for its future applications in biotechnology and nanomedicine.

Phthalazine-trione as a blue-green light-emitting moiety: crystal structures, photoluminescence and theoretical calculations

2019 ◽  
Vol 43 (3) ◽  
pp. 1313-1321
Author(s):  
Felipe Terra Martins ◽  
Lauro June Queiroz Maia ◽  
Gisane Gasparotto ◽  
Ana Karoline Silva Medanha Valdo ◽  
José Antônio Nascimento Neto ◽  
...  
Keyword(s):  
Crystal Structures ◽  
Theoretical Calculations ◽  
Green Light ◽  
Substitution Pattern ◽  
Light Emitting

Phthalazine-trione was found to be a new robust blue-green light-emitting fluorophore, regardless of the substitution pattern.

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