scholarly journals Modular triazine-based carborane-containing carboxylic acids – synthesis and characterisation of potential boron neutron capture therapy agents made of readily accessible building blocks

2019 ◽  
Vol 48 (29) ◽  
pp. 10834-10844 ◽  
Author(s):  
Martin Kellert ◽  
Dennis J. Worm ◽  
Paul Hoppenz ◽  
Menyhárt B. Sárosi ◽  
Peter Lönnecke ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Carboxylic Acids ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Building Blocks ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture

Boron-rich carboxylic acid derivatives were synthesised as coupling partners for tumour-selective biomolecules with applications as selective BNCT agents.

scholarly journals Tuning a modular system – synthesis and characterisation of a boron-rich s-triazine-based carboxylic acid and amine bearing a galactopyranosyl moiety

2020 ◽  
Vol 49 (1) ◽  
pp. 57-69 ◽  
Author(s):  
Martin Kellert ◽  
Paul Hoppenz ◽  
Peter Lönnecke ◽  
Dennis J. Worm ◽  
Bernd Riedl ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Carboxylic Acids ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Modular System ◽  
Neutron Capture Therapy ◽  
System Synthesis ◽  
Boron Neutron Capture

Introduction of a galactopyranosyl moiety in s-triazine-based boron-rich carboxylic acids and amines results in soluble and suitable coupling partners for tumour-selective biomolecules with applications in boron neutron capture therapy (BNCT).

Synthesis of new building blocks for boron-rich oligomers in boron neutron capture therapy (BNCT). I.

1994 ◽  
Vol 35 (34) ◽  
pp. 6217-6220 ◽  
Author(s):  
Karin Drechsel ◽  
Christine S. Lee ◽  
Eamon W. Leung ◽  
Robert R. Kane ◽  
M.Frederick Hawthorne
Keyword(s):  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Building Blocks ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture

scholarly journals Enlargement of a Modular System—Synthesis and Characterization of an s-Triazine-Based Carboxylic Acid Ester Bearing a Galactopyranosyl Moiety and an Enormous Boron Load

Molecules ◽  
2019 ◽  
Vol 24 (18) ◽  
pp. 3288 ◽  
Author(s):  
Martin Kellert ◽  
Peter Lönnecke ◽  
Bernd Riedl ◽  
Johannes Koebberling ◽  
Evamarie Hey-Hawkins
Keyword(s):  
Carboxylic Acid ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Acid Ester ◽  
Tumor Tissue ◽  
Modular System ◽  
Synthesis And Characterization ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture

The amount of boron accumulated in tumor tissue plays an important role regarding the success of the boron neutron capture therapy (BNCT). In this article, we report a modular system, combining readily available starting materials, like glycine, 1,3,5-triazine and the well-known 9-mercapto-1,7-dicarba-closo-dodecaborane(12), as well as α-d-galactopyranose for increased hydrophilicity, with a novel boron-rich tris-meta-carboranyl thiol.

Synthesis of new building blocks for boron-rich oligomers in boron neutron capture therapy (BNCT). II. Monomers derived from 2,2-disubstituted-1,3-diols

1995 ◽  
Vol 36 (29) ◽  
pp. 5147-5150 ◽  
Author(s):  
Young Soo Kim ◽  
Robert R. Kane ◽  
Cynthia L. Beno ◽  
Solomon Romano ◽  
Gabriel Mendez ◽  
...  
Keyword(s):  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Building Blocks ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture

Synthesis of conjugates of L-fucose and ortho-carborane as potential agents for boron neutron capture therapy

2002 ◽  
Vol 80 (8) ◽  
pp. 943-948 ◽  
Author(s):  
Prakriti Basak ◽  
Todd L Lowary
Keyword(s):  
Carboxylic Acid ◽  
Key Words ◽  
Acid Chloride ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Neutron Capture Therapy ◽  
Carboxylic Acid Chloride ◽  
Boron Neutron Capture

The synthesis of three potential boron neutron capture therapy agents (6–8) is reported. The compounds synthesized are comprised of ortho-carborane covalently attached to L-fucose via C-6. Incorporation of the carborane moiety was achieved either through the reaction of an L-fucose-derived alkyne with decaborane or by the coupling of a 6-amino-L-galactopyranose derivative with carborane carboxylic acid chloride (18).Key words: L-fucose, fucosyltransferase, boron neutron capture therapy, ortho-carborane.

Sign in / Sign up

Export Citation Format

Share Document