scholarly journals Visible light-induced cytotoxicity studies on Co(ii) complexes having an anthracene-based curcuminoid ligand

2019 ◽  
Vol 48 (34) ◽  
pp. 12933-12942 ◽  
Author(s):  
Dhananjay Das ◽  
Atrayee Banaspati ◽  
Namisha Das ◽  
Bidisha Bora ◽  
Md Kausar Raza ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Visible Light ◽  
Human Serum ◽  
Calf Thymus Dna ◽  
Cytotoxicity Studies ◽  
Calf Thymus ◽  
Mcf 7

Co(ii) complexes having an anthracene-based curcuminoid ligand display moderate binding propensity towards calf thymus DNA and human serum albumin and remarkable photo-cytotoxicity in HeLa, MCF-7 and MDA-MB-231 cells on excitation with visible light.

Ionophoric polyphenols are permeable to the blood–brain barrier, interact with human serum albumin and Calf Thymus DNA, and inhibit AChE enzymatic activity

2020 ◽  
Vol 29 (11) ◽  
pp. 1956-1975
Author(s):  
Alberto Martínez ◽  
Mai Zahran ◽  
Miguel Gomez ◽  
Johnny Guevara ◽  
Rosemary Pichardo-Bueno ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Enzymatic Activity ◽  
Human Serum ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Calf Thymus Dna ◽  
Blood Brain ◽  
Calf Thymus

Anticancer activity, calf thymus DNA and human serum albumin binding properties of Farnesiferol C from Ferula pseudalliacea

2018 ◽  
Vol 37 (11) ◽  
pp. 2789-2800 ◽  
Author(s):  
Hamid Tanzadehpanah ◽  
Hanie Mahaki ◽  
Pouria Samadi ◽  
Jamshid Karimi ◽  
Neda Hosseinpour Moghadam ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Anticancer Activity ◽  
Calf Thymus Dna ◽  
Albumin Binding ◽  
Binding Properties ◽  
Calf Thymus ◽  
Human Serum Albumin Binding

The Use Of Molecular Docking And Spectroscopic Methods For Investigation Of The Interaction Between Regorafenib With Human Serum Albumin (HSA) And Calf Thymus DNA (Ct-DNA) In The Presence Of Different Site Markers

2020 ◽  
Vol 27 ◽  
Author(s):  
Hamid Tanzadehpanah ◽  
Hanie Mahaki ◽  
Mohammadreza Moradi ◽  
Saeid Afshar ◽  
Neda Hosseinpour Moghadam ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Human Serum Albumin ◽  
Zeta Potential ◽  
Serum Albumin ◽  
Human Serum ◽  
Calf Thymus Dna ◽  
Static Mode ◽  
Calf Thymus ◽  
Site Markers ◽  
Ct Dna

Background: Interactions of drugs with DNA and proteins may modify their biological activities and conformations, which effect transport and biological metabolism of drugs. Objective: In this study the interaction of anticancer drug regorafenib (REG) with calf thymus-DNA (ct-DNA) and human serum albumin (HSA) has been investigated. Methods: Hence, for the first time, it was discovered interaction between REG with DNA and HSA using multispectroscopic, zeta potential measurements and molecular docking method. Results and Discussion: DNA displacement studies showed that REG does not have any effect on acridine orange and methylene blue bound DNA, though it was substantiated by displacement studies with Hoechst (as groove binder). Furthermore, the different concentrations of REG induce slight changes in the viscosity of ct-DNA. Zeta potential parameters indicated that hydrophobic interaction plays a major role in the DNA-REG complex. Results obtained from molecular docking demonstrate that the REG prefers to bind on the minor groove of DNAs than that of the major groove. Binding properties of HSA reveal that intrinsic fluorescence of HSA could be quenched by REG in a static mode. The competitive experiments in the presence of warfarin and ibuprofen (as site markers) suggested that the binding site of REG to HSA was most probably located in the subdomain IIA. Measurements of the zeta potential indicated that REG bound to HSA mainly by both electrostatic and hydrophobic interactions. It was found on docking procedures that REG could fit well into HSA subdomain IIA, which confirmed the experimental results. Conclusion: In conclusion, REG can be delivered by HSA in a circulatory system and affect DNA as potential target.

Sign in / Sign up

Export Citation Format

Share Document