scholarly journals Gas-phase structures reflect the pain-relief potency of enkephalin peptides

2019 ◽  
Vol 21 (41) ◽  
pp. 22700-22703
Author(s):  
Aleksandr Y. Pereverzev ◽  
István Szabó ◽  
Vladimir N. Kopysov ◽  
Edina Rosta ◽  
Oleg V. Boyarkin
Keyword(s):  
Pain Relief ◽  
Gas Phase ◽  
Opioid Receptors ◽  
Phase Structures

Gas-phase structures can be used for evaluating the binding efficiency of enkephalin drugs into the hydrophobic pockets of opioid receptors.

The gas-phase structures of perfluoroquinolizidine and perfluorotripropylamine

1989 ◽  
Vol 197 ◽  
pp. 329-338 ◽  
Author(s):  
Hans-Georg Mack ◽  
Heinz Oberhammer
Keyword(s):  
Gas Phase ◽  
Phase Structures

Gas-phase structures of ethynyl- and vinyl pentafluorosulfur derivatives: an electron diffraction and microwave spectroscopy study

1991 ◽  
Vol 249 (2-4) ◽  
pp. 285-295 ◽  
Author(s):  
Petra Zylka ◽  
Dines Christen ◽  
Heinz Oberhammer ◽  
Gary L. Gard ◽  
R.J. Terjeson
Keyword(s):  
Electron Diffraction ◽  
Gas Phase ◽  
Microwave Spectroscopy ◽  
Spectroscopy Study ◽  
Phase Structures

The (p-d) .pi. bonding in fluorosilanes? Gas-phase structures of (CH3)4-nSiFn with n = 1-3 and of (tert-Bu)2SiF2

1986 ◽  
Vol 108 (14) ◽  
pp. 3893-3897 ◽  
Author(s):  
Beate. Rempfer ◽  
Heinz. Oberhammer ◽  
Norbert. Auner
Keyword(s):  
Gas Phase ◽  
Phase Structures

scholarly journals POST-OPERATIVE PAIN RELIEF FOR LOWER ABDOMINAL SURGERY

2005 ◽  
Vol 12 (03) ◽  
pp. 340-345
Author(s):  
ROBINA FIRDOUS
Keyword(s):  
Pain Management ◽  
Side Effects ◽  
Pain Relief ◽  
Abdominal Surgery ◽  
Opioid Receptors ◽  
Acute Pain ◽  
Alternate Route ◽  
Parenteral Route ◽  
Group I ◽  
Post Operative Pain

The severity of post-operative pain and the lack of efforts in relievingit have led to the involvement of Anaesthesiologists in the management of post-operative and acute pain. Parenteralopiates have been utilized for post-operative pain management. The identification of the opioid receptors on substantiagelatinosa has provided an alternate route i.e 1 the epidural route - for administering opiates. Objectives: To evaluateand compare the efficacy and side effects of parenteral Buprenorphine with those of Extradural Buprenorphine.Setting: Department of Anaesthesia, District Headquarter Hospital, Faisalabad. Period: The data was collected duringthe last three and a half years. Materials and Methods: Sixty adult patients of either sex and ages ranging from 35-45years, who underwent lower abdominal surgery, were randomly selected for the study. They were equally divided intotwo groups. Group I patients were administered Buprenorphine 0.3 mg through the epidural catheter in extraduralspace. Group II patients were given Buprenorphine 0.3 mg intramuscularly. Results: Buprenorphine through theepidural route gives better analgesia with fewer side effects as compared with the parenteral route.

scholarly journals EFFECTS OF NEW PIPERIDINE DERIVATIVES WITH SUBSTITUTIONS IN THE 1ST AND 4TH POSITIONS IN NALOXONE SENSITIVE ANALGESY

2021 ◽  
Vol 19 (5) ◽  
pp. 501-505
Author(s):  
A. A. Vasilyuk ◽  
◽  
V. I. Kozlovsky ◽  
G. S. Akhmetova ◽  
V. K. Yu ◽  
...  
Keyword(s):  
Pain Relief ◽  
Receptor Antagonist ◽  
Opioid Receptor ◽  
Opioid Receptors ◽  
Analgesic Effect ◽  
Chemical Stimulation ◽  
Analgesic Action ◽  
Preliminary Administration ◽  
Chemical Irritation

Background. Despite the wide arsenal of painkillers, pain relief is an urgent interdisciplinary problem that requires a search for new solutions. Purpose of the study. To establish the role of opioid receptors in the mechanism of the analgesic action of the piperidine derivatives AGV-22 and AGV-23. Material and methods. The studies were carried out on 96 white mice of both sexes weighing 30-40 g. The analgesic effect of the compounds was tested on models of thermal and chemical irritation with preliminary administration of the opioid receptor antagonist naloxone. Results. The pain reactions of mice with models of thermal and chemical stimulation in the AGV-22 / AGV-23 + naloxone and AGV-22 / AGV-23 groups were comparable. Conclusions. The mechanism of the analgesic action of the piperidine derivatives AGV-22 and AGV-23 is not associated with the activation of opioid receptors.

scholarly journals Compaction of RNA Hairpins and Their Kissing Complexes in Native Electrospray Mass Spectrometry

2020 ◽  
Author(s):  
Joséphine Abi-Ghanem ◽  
Clémence Rabin ◽  
Massimiliano Porrini ◽  
Frédéric Rosu ◽  
Valerie Gabelica
Keyword(s):  
Mass Spectrometry ◽  
Molecular Dynamics ◽  
Gas Phase ◽  
Electrospray Mass Spectrometry ◽  
Initial Structure ◽  
Native Solution ◽  
Phase Structures ◽  
Rna Hairpins ◽  
Level Calculation ◽  
Structure In Solution

When electrosprayed from native solution conditions, RNA hairpins and kissing complexes acquire charge states at which they get significantly more compact in the gas phase than their initial structure in solution. Here we show the limits of using force field molecular dynamics to interpret the gas-phase structures of nucleic acid complexes in the gas phase, and we suggest that higher-level calculation levels should be used in the future.<br>

scholarly journals Conformational Transformations of Sulfur-Containing Rings: 2-Methyltetrahydrothiophene Gas-Phase Structures

ChemPhysChem ◽  
2015 ◽  
Vol 16 (2) ◽  
pp. 265-265
Author(s):  
Vinh Van ◽  
Christina Dindic ◽  
Ha Vinh Lam Nguyen ◽  
Wolfgang Stahl
Keyword(s):  
Gas Phase ◽  
Phase Structures ◽  
Conformational Transformations ◽  
Sulfur Containing

Deprotonated carbohydrate anion fragmentation chemistry: structural evidence from tandem mass spectrometry, infra-red spectroscopy, and theory

2018 ◽  
Vol 20 (44) ◽  
pp. 27897-27909 ◽  
Author(s):  
Jordan M. Rabus ◽  
Daniel R. Simmons ◽  
Philippe Maître ◽  
Benjamin J. Bythell
Keyword(s):  
Mass Spectrometry ◽  
Infrared Spectroscopy ◽  
Tandem Mass Spectrometry ◽  
Gas Phase ◽  
Tandem Mass ◽  
Phase Structures ◽  
Infra Red ◽  
Fragmentation Chemistry

We investigate the gas-phase structures and fragmentation chemistry of deprotonated carbohydrate anions using combined tandem mass spectrometry, infrared spectroscopy, regioselective labelling, and theory.

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