Large volume liquid state scalar Overhauser dynamic nuclear polarization at high magnetic field

2019 ◽  
Vol 21 (38) ◽  
pp. 21200-21204 ◽  
Author(s):  
Thierry Dubroca ◽  
Sungsool Wi ◽  
Johan van Tol ◽  
Lucio Frydman ◽  
Stephen Hill
Keyword(s):  
Magnetic Field ◽  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Magnetic Fields ◽  
High Magnetic Field ◽  
Dynamic Nuclear Polarization ◽  
Large Volume ◽  
Liquid State ◽  
Nuclear Polarization ◽  
High Magnetic Fields

Dynamic Nuclear Polarization (DNP) can increase the sensitivity of Nuclear Magnetic Resonance (NMR), but it is challenging in the liquid state at high magnetic fields.

SABRE Hyperpolarization of Bipyridine Stabilized Ir-Complex at High, Low and Ultralow Magnetic Fields

2017 ◽  
Vol 231 (3) ◽  
Author(s):  
Andrey N. Pravdivtsev
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Magnetic Fields ◽  
Dynamic Nuclear Polarization ◽  
Signal Amplification ◽  
Nuclear Polarization ◽  
Optical Pumping ◽  
Spin Exchange ◽  
Spin Exchange Optical Pumping ◽  
Wide Range

AbstractA strong limitation of nuclear magnetic resonance is its low inherent sensitivity that can be overcome by using an appropriate hyperpolarization technique. Presently, dynamic nuclear polarization and spin-exchange optical pumping are the only hyperpolarization techniques that are used in applied medicine. However, both are relatively complex in use and expensive. Here we present a modification of the signal amplification by reversible exchange (SABRE) hyperpolarization method – SABRE on stabilized Ir-complexes. A stabilized Ir-complex (here we used bipyridine for stabilization) can be hyperpolarized in a wide range of magnetic fields from a few μT upto 10 T with

High-field liquid state NMR hyperpolarization: a combined DNP/NMRD approach

2014 ◽  
Vol 16 (35) ◽  
pp. 18781-18787 ◽  
Author(s):  
Petr Neugebauer ◽  
Jan G. Krummenacker ◽  
Vasyl P. Denysenkov ◽  
Christina Helmling ◽  
Claudio Luchinat ◽  
...  
Keyword(s):  
Magnetic Field ◽  
High Magnetic Field ◽  
Dynamic Nuclear Polarization ◽  
Liquid State ◽  
High Field ◽  
Nuclear Polarization ◽  
Nmr Relaxation ◽  
Relaxation Dispersion ◽  
Liquid Solutions ◽  
High Fields

Dynamic nuclear polarization and NMR relaxation dispersion measurements have been performed on liquid solutions of TEMPOL radicals in solvents with different viscosities at a high magnetic field of 9.2 T. The results indicate that fast dynamics significantly contribute to DNP enhancements at high fields.

scholarly journals Fast and accurate MAS–DNP simulations of large spin ensembles

2017 ◽  
Vol 19 (5) ◽  
pp. 3506-3522 ◽  
Author(s):  
Frédéric Mentink-Vigier ◽  
Shimon Vega ◽  
Gaël De Paëpe
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Magnetic Fields ◽  
Dynamic Nuclear Polarization ◽  
Nuclear Polarization ◽  
Magic Angle Spinning ◽  
Successful Implementation ◽  
Magic Angle ◽  
Angle Spinning ◽  
Large Spin

A deeper understanding of parameters affecting Magic Angle Spinning Dynamic Nuclear Polarization (MAS–DNP), an emerging nuclear magnetic resonance hyperpolarization method, is crucial for the development of new polarizing agents and the successful implementation of the technique at higher magnetic fields (>10 T).

scholarly journals J-driven Dynamic Nuclear Polarization for sensitizing high field solution state NMR

2022 ◽  
Author(s):  
Maria Grazia Concilio ◽  
Ilya Kuprov ◽  
Lucio Frydman
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Solid State ◽  
Magnetic Resonance ◽  
Dynamic Nuclear Polarization ◽  
Liquid State ◽  
High Field ◽  
Nuclear Polarization ◽  
Solution State ◽  
Field Solution ◽  
Nmr Sensitivity

Dynamic nuclear polarization (DNP) is widely used to enhance solid state nuclear magnetic resonance (NMR) sensitivity. Its efficiency as a generic signal-enhancing approach for liquid state NMR, however, decays rapidly...

Nuclear magnetic resonance microscopy

1989 ◽  
Vol 47 ◽  
pp. 828-829
Author(s):  
Paul C. Lauterbur
Keyword(s):  
Magnetic Field ◽  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Magnetic Fields ◽  
Signal To Noise ◽  
Field Gradients ◽  
Useful Signal ◽  
Magnetic Field Gradients ◽  
Observation Times ◽  
Nuclear Magnetic

Nuclear magnetic resonance imaging can reach microscopic resolution, as was noted many years ago, but the first serious attempt to explore the limits of the possibilities was made by Hedges. Resolution is ultimately limited under most circumstances by the signal-to-noise ratio, which is greater for small radio receiver coils, high magnetic fields and long observation times. The strongest signals in biological applications are obtained from water protons; for the usual magnetic fields used in NMR experiments (2-14 tesla), receiver coils of one to several millimeters in diameter, and observation times of a number of minutes, the volume resolution will be limited to a few hundred or thousand cubic micrometers. The proportions of voxels may be freely chosen within wide limits by varying the details of the imaging procedure. For isotropic resolution, therefore, objects of the order of (10μm) may be distinguished.Because the spatial coordinates are encoded by magnetic field gradients, the NMR resonance frequency differences, which determine the potential spatial resolution, may be made very large. As noted above, however, the corresponding volumes may become too small to give useful signal-to-noise ratios. In the presence of magnetic field gradients there will also be a loss of signal strength and resolution because molecular diffusion causes the coherence of the NMR signal to decay more rapidly than it otherwise would. This phenomenon is especially important in microscopic imaging.

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