scholarly journals Structural determinants of coiled coil mechanics

2019 ◽  
Vol 21 (18) ◽  
pp. 9145-9149 ◽  
Author(s):  
Patricia López-García ◽  
Melis Goktas ◽  
Ana E. Bergues-Pupo ◽  
Beate Koksch ◽  
Daniel Varón Silva ◽  
...  
Keyword(s):  
Packing Density ◽  
Coiled Coil ◽  
Hydrophobic Core ◽  
Sequence Structure ◽  
Structural Determinants ◽  
Helix Propensity ◽  
The Individual ◽  
Relationship Of

In shear geometry, the sequence–structure–mechanics relationship of rationally designed coiled coil heterodimers is determined by the helix propensity of the individual helices and the packing density at the hydrophobic core.

scholarly journals Structural Determinants of Coiled Coil Mechanics

2019 ◽  
Author(s):  
Patricia Lopez-Garcia ◽  
Melis Goktas ◽  
Ana E. Bergues-Pupo ◽  
Beate Koksch ◽  
Daniel Varon Silva ◽  
...  
Keyword(s):  
Transition State ◽  
Single Molecule ◽  
Mechanical Stability ◽  
Coiled Coil ◽  
Building Blocks ◽  
Shear Loading ◽  
Hydrophobic Core ◽  
Structural Determinants ◽  
Helix Propensity ◽  
Core Packing

The natural abundance of coiled coil (CC) motifs in the cytoskeleton and the extracellular matrix suggests that CCs play a crucial role in the bidirectional mechanobiochemical signaling between cells and the matrix. Their functional importance and structural simplicity has allowed the development of numerous applications, such as protein-origami structures, drug delivery systems and biomaterials. With the goal of establishing CCs as nanomechanical building blocks, we investigated the importance of helix propensity and hydrophobic core packing on the mechanical stability of 4-heptad CC heterodimers. Using single-molecule force spectroscopy, we show that both parameters determine the force-induced dissociation in shear loading geometry; however, with different effects on the energy landscape. Decreasing the helix propensity lowers the transition barrier height, leading to a concomitant decrease in the distance to the transition state. In contrast, a less tightly packed hydrophobic core increases the distance to the transition state. We propose that this sequence-structure-mechanics relationship is evolutionarily optimized in natural CCs and can be used for tuning their mechanical properties in applications.

CHILD-PARENT RELATIONS AS A FACTOR IN THE FORMATION OF PROFESSIONAL PREFERENCES IN PEDAGOGICAL DYNASTIES

2020 ◽  
Vol 2 (4) ◽  
pp. 126-130
Author(s):  
N. V. SHAMANIN ◽  
Keyword(s):  
Professional Development ◽  
The Family ◽  
The Individual ◽  
Relationship Of ◽  
The Relationship ◽  
Parent Child Relationships ◽  
Professional Preferences ◽  
Parent Child

The article raises the issue of the relationship of parent-child relationships and professional preferences in pedagogical dynasties. Particular attention is paid to the role of the family in the professional development of the individual. It has been suggested that there is a relationship between parent-child relationships and professional preferences.

Epilogue

2017 ◽  
Author(s):  
Joshua S. Walden
Keyword(s):  
The Body ◽  
The Self ◽  
The Individual ◽  
Relationship Of ◽  
The Relationship

The book’s epilogue explores the place of musical portraiture in the context of posthumous depictions of the deceased, and in relation to the so-called posthuman condition, which describes contemporary changes in the relationship of the individual with such aspects of life as technology and the body. It first examines Alfred Hitchcock’s Vertigo to view how Bernard Herrmann’s score relates to issues of portraiture and the depiction of the identity of the deceased. It then considers the work of cyborg composer-artist Neil Harbisson, who has aimed, through the use of new capabilities of hybridity between the body and technology, to convey something akin to visual likeness in his series of Sound Portraits. The epilogue shows how an examination of contemporary views of posthumous and posthuman identities helps to illuminate the ways music represents the self throughout the genre of musical portraiture.

Parasitic infection and chronic energy deficiency in adults

Parasitology ◽  
1993 ◽  
Vol 107 (S1) ◽  
pp. S159-S167 ◽  
Author(s):  
P. S. Shetty ◽  
N. Shetty
Keyword(s):  
Nutritional Status ◽  
Health Workers ◽  
Parasitic Infection ◽  
Critical Determinant ◽  
Energy Deficiency ◽  
Chronic Energy Deficiency ◽  
Wide Range ◽  
The Individual ◽  
The Tropics ◽  
Relationship Of

Interactions between infection and nutrition have been well recognized for several years now since they contribute directly to the health of individuals and communities. Malnourished individuals are specially prone to developing infections while infections themselves can lead to profound changes in the nutritional status of the individual. Health workers in developing countries in the tropics have long recognized the mutually aggravating interactions of malnutrition and infection. The importance of this synergistic relationship between infection and nu-tritional status has been studied extensively in the case of young children. The nutritional status of a young child is a critical determinant of both c morbidity and mortality resulting from a wide range of infections: bacterial, viral, or parasitic. Chandra (1983), in his review on the relationship of nutrition, immunity and infection has categorized the wide range of infectious agents (bacterial, viral, fungal and parasitic) into those that are definitely, variably or minimally influenced by the nutritional status of the child.

scholarly journals Structural Determinants in Family Planning Service Utilization in Ethiopia: EDHS 2011 Analysis

2015 ◽  
Vol 2015 ◽  
pp. 1-17 ◽  
Author(s):  
Jembere Gizachew Balew ◽  
Yongtae Cho ◽  
Clara Tammy Kim ◽  
Woorim Ko
Keyword(s):  
Family Planning ◽  
Family Planning Service ◽  
Behavioral Changes ◽  
Media Access ◽  
Planning Service ◽  
Structural Determinants ◽  
Fertility Reduction ◽  
The Individual ◽  
Cluster Level ◽  
Significant Factors

Family planning coverage has improved in Ethiopia in the last decade, though fertility is still about 5.8 in the rural setup. In this paper, the major structural determinants of family planning service were analyzed using a multilevel model from 8906 individual women observation in the 2011 EDHS data. The results show that there is a big variation in family planning use both at the individual and between group levels. More than 39% of the variation in FP use is explained by contextual cluster level differences. Most of the socioeconomic predictors; respondent’s education, ethnicity, and partners’ education as well as employment status and urbanization were found to be significant factors that affect FP use. Similarly health extension visit and media access were found to be strong factors that affect FP service at both individual and cluster levels. This evidence concludes that addressing these contextual factors is very crucial to strengthen FP use and fertility reduction in the nation, beyond individual behavioral changes.

scholarly journals The specifics of interpretation of the history in the story by A. Doronin «A Wolf Ravine»

2021 ◽  
Vol 11 (1) ◽  
pp. 139-147
Author(s):  
S. V. Sheyanova ◽  
◽  
N. M. Yusupova ◽  
Keyword(s):  
Literary Criticism ◽  
Historical Narrative ◽  
Volga Region ◽  
Psychological States ◽  
The Real ◽  
The Subject ◽  
The Individual ◽  
Relationship Of ◽  
First Time ◽  
The Relationship

Introduction: at present the reader’s audience is particularly interested in creative experiments in which the historical fate of the Russian peasantry in the «turning» eras is artistically comprehended. The article is devoted to the study of the problem-thematic range of modern Mordovian historical prose. The subject of analysis is the peculiarity of the reception of the period of collectivization and dekulakization in the story by Erzyan prose writer A. Doronin «A Wolf Ravine». Objective: to reveal the features of the artistic reconstruction of the events of the 1930s, the modeling of the relationship between a man and society in the story by A. Doronin «A Wolf Ravine».Research materials: the story by A. Doronin «A Wolf Ravine». Results and novelty of the research: the historical story « A Wolf Ravine » for the first time becomes the object of scientific understanding and is introduced into the context of Finno-Ugric literary criticism. A. Doronin artistically interprets the real events and circumstances of the resettlement of dispossessed peasants of the Volga region to the uninhabited steppes of Kazakhstan. As a result of the study, we conclude that the actualization of this problem-thematic cluster is due to the creative concept of the historical writer; the individual author’s approach to the reconstruction of historical narrative can be traced in the writer’s desire to realistically reveal the relationship of personality and society in the tragic 1930s; to analyze intentions of people and of the psychological states of the characters. Problems of a sociopolitical nature, actualized in the story, are filled with philosophical, axiological content, and lead to a multi-faceted understanding of the «man and history» problem.

scholarly journals Analysis of Nurse Characteristics with Work Motivation in Wamena Hospital

2021 ◽  
Vol 5 (1) ◽  
pp. 35-41
Author(s):  
Moses Lamere ◽  
Ratna Wardani
Keyword(s):  
Marital Status ◽  
Work Motivation ◽  
Statistical Tests ◽  
Sampling Technique ◽  
Simple Random Sampling ◽  
Hospital Inpatient ◽  
Meaningful Relationship ◽  
Gender Education ◽  
The Individual ◽  
Relationship Of

Lately there has been attention to work dissatisfaction and declining quality. Most people find it difficult to motivate themselves, therefore it is not surprising that motivating others is a difficult and complicated task. Motivation indicates the process of movement, including the encouraging situation that arises within the individual, the behavior caused by the situation and the purpose or end of the movement or action. The purpose of this study was to analyze the relationship of nurse characteristics with work motivation in Wamena Hospital inpatient room. This type of research is quantitative with an observational approach. The population is the entire nursing plant in Wamena Hospital with 186 people. Large samples were taken as many as 64 respondents. Sampling techniques used in this study is a simple random sampling technique. Based on the results of the study it is known that there is a meaningful relationship between age, working period and position with work motivation. While there are several factors that are not related to work motivation, namely gender, education and marital status. The statistical test used is path analysis. Statistical tests can be concluded that there is a meaningful relationship to variables as follows: the characteristics of nurses that affect work motivation are age, years of service and position, while the characteristics of gender, education and marital status do not have a significant relationship with work motivation. Based on the results of the study is expected to improve the ability and insight of nursing and motivation of work so that their productivity does not decrease. For example, give remuneration, promotion and periodic reward for outstanding nurses will encourage the motivation of nurse work to develop.

scholarly journals Analysis of the Relationship of Professionals towards the Vertical Equity of the Slovenian Tax System and Its Comparison with Croatia, Bosnia and Herzegovina and the USA

2018 ◽  
Vol 15 (3-4) ◽  
pp. 145-166
Author(s):  
Jelena Klopčič ◽  
Maja Klun
Keyword(s):  
Bosnia And Herzegovina ◽  
The United States ◽  
Vertical Equity ◽  
Tax System ◽  
Equity Principle ◽  
The Usa ◽  
Survey Results ◽  
The Individual ◽  
Relationship Of ◽  
The Relationship

Vertical equity states that taxpayers whose positions are not the same should be treated differently while taking into consideration all the relevant characteristics. The main purpose of using the vertical equity principle is to require the redistribution of income in a way that reduces the income inequality of the society. The presented research aims to check the opinion of Slovenian tax system professionals on the principle of vertical equity. Slovenian results have been compared to a similar analysis carried out in Croatia, and partly with survey results from Bosnia and Herzegovina and the United States of America. The results show that the professional public agrees with the principle of vertical equity in the implementation of tax systems. All of the compared countries are similarly favourable towards vertical equity. However, this is also affected by the current tax arrangements of the individual countries.

scholarly journals Sperm ultrastructure of Pochazia shantungensis (Chou & Lu) and Ricania speculum (Walker) (Hemiptera, Ricaniidae) with phylogenetic implications

ZooKeys ◽  
2019 ◽  
Vol 880 ◽  
pp. 43-59
Author(s):  
Zhen Jiang ◽  
Jianing Liu ◽  
Daozheng Qin
Keyword(s):  
Neck Region ◽  
Mature Spermatozoon ◽  
Current Evidence ◽  
Sperm Ultrastructure ◽  
Transmission Electron ◽  
Phylogenetic Implications ◽  
Dense Substance ◽  
The Individual ◽  
Relationship Of ◽  
Centriole Adjunct

The sperm ultrastructure of two ricaniid species, Pochazia shantungensis (Chou & Lu) and Ricania speculum (Walker), was investigated using light and transmission electron microscopy. Both species have monoflagellate sperm, the shape and ultrastructure of the mature spermatozoon of these two species are similar in morphology, and 128 spermatozoa are organized into sperm bundles with their heads embedded in a homogenous matrix forming the spermatodesmata. The individual sperm is filiform and includes the head, neck and flagellum. The head is needle-like, with a bilayer acrosome and an inferior elongated nucleus which is formed of homogeneously compact and electron-dense chromatin. The neck region is indistinct and is comprised of the centriole and centriole adjunct with a homogeneous dense substance. The long flagellum has the typical 9 + 9 + 2 axoneme microtubule pattern and two symmetrical mitochondrial derivatives with an orderly array of cristae flanking both sides, and a pair of well-developed fishhook-shaped accessory bodies. Current evidence shows that ricaniid species have D-shaped mitochondrial derivatives in cross-section and a serrated electron-dense region. The phylogenetic relationship of Fulgoroidea with other superfamilies in Auchenorrhyncha is briefly discussed.

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