Color tuning of an active pharmaceutical ingredient through cocrystallization: a case study of a metronidazole–pyrogallol cocrystal

CrystEngComm ◽  
2020 ◽  
Vol 22 (8) ◽  
pp. 1404-1413 ◽  
Author(s):  
Kang Zheng ◽  
Sijia Gao ◽  
Meishan Chen ◽  
Ao Li ◽  
Weiwei Wu ◽  
...  
Keyword(s):  
Active Pharmaceutical Ingredient ◽  
Antimicrobial Drug ◽  
Color Tuning ◽  
Visual Color

The visual color of antimicrobial drug metronidazole is tuned through cocrystallization with pyrogallol, offering a new modification approach.

Polybenzimidazole for Active Pharmaceutical Ingredient Purification: The Mometasone Furoate Case Study

2019 ◽  
Vol 58 (24) ◽  
pp. 10524-10532 ◽  
Author(s):  
Flávio Alves Ferreira ◽  
Teresa Esteves ◽  
Marta P. Carrasco ◽  
João Bandarra ◽  
Carlos A. M. Afonso ◽  
...  
Keyword(s):  
Active Pharmaceutical Ingredient ◽  
Mometasone Furoate

Life Cycle Analysis within Pharmaceutical Process Optimization and Intensification: Case Study of Active Pharmaceutical Ingredient Production

ChemSusChem ◽  
2014 ◽  
Vol 7 (12) ◽  
pp. 3521-3533 ◽  
Author(s):  
Denise Ott ◽  
Dana Kralisch ◽  
Ivana Denčić ◽  
Volker Hessel ◽  
Yosra Laribi ◽  
...  
Keyword(s):  
Life Cycle ◽  
Process Optimization ◽  
Life Cycle Analysis ◽  
Active Pharmaceutical Ingredient

Eco-efficiency Analysis for Intensified Production of an Active Pharmaceutical Ingredient: A Case Study

2014 ◽  
Vol 18 (11) ◽  
pp. 1326-1338 ◽  
Author(s):  
Ivana Denčić ◽  
Denise Ott ◽  
Dana Kralisch ◽  
Timothy Noël ◽  
Jan Meuldijk ◽  
...  
Keyword(s):  
Active Pharmaceutical Ingredient ◽  
Efficiency Analysis

scholarly journals VOLUMETRIC COLOR APPROACH AS APPLICATION OF VISUAL COLOR IN SPACE ZONING CONCEPT

2020 ◽  
Vol 5 (1) ◽  
pp. 67
Author(s):  
Qobus Tsaqif ◽  
Ully Irma Maulina Hanafiah
Keyword(s):  
Interior Design ◽  
Positive Impact ◽  
Descriptive Analysis ◽  
Psychological Space ◽  
Space Design ◽  
Visual Color ◽  
Space Limitation ◽  
The Difference ◽  
And Function

In the development of interior design, many are applied to create an atmosphere that can create aesthetics and convenience for users. A design can develop through interior elements, especially through color and shape. In a space design with various functions it creates its own zoning at various activities. The emphasis on zoning can be developed through an interior design with the concept of distinct space, by applying various elements that can distinguish space, such as color elements. Volumetric Color approach which uses colors to create a volume of space in an area by using the same color in all interior elements. The difference in color and shape of space creates zoning and function in space to be more specific. In addition to zoning, the use of different and striking colors can provide vocal points and aesthetics in space. The purpose of this descriptive-analysis research is to make a systematic, factual and accurate description, picture, or painting of a case study producing a space with attractive volumetric colors, and as an identity in space. The results of this study can play a role in interior design in the use of color not only as aesthetics of the space, also can provide convenience for users to recognize areas that exist with different functions. In addition, the use of colors in accordance with the function of the area can also be adjusted to affect the psychological space that can have a positive impact on space. Keywords: Volumetric Color, Zoning of Space, Limitation of Space Functions

Predictive thermodynamic modeling and experimental measurements on solubility of active pharmaceutical ingredient: Lornoxicam case study

2021 ◽  
pp. 115285
Author(s):  
Rasool Pelalak ◽  
Behnam Rahzani ◽  
Aliakbar Khoshmaram ◽  
Safoura Hosseini ◽  
Sahar Jamshidian ◽  
...  
Keyword(s):  
Thermodynamic Modeling ◽  
Active Pharmaceutical Ingredient ◽  
Experimental Measurements

scholarly journals Physicochemical Properties of Poly-vinyl Polymers and Their Influence on Ketoprofen Amorphous Solid Dispersion Performance: A Polymer Selection Case Study

Pharmaceutics ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 433 ◽  
Author(s):  
Emer Browne ◽  
Zelalem A. Worku ◽  
Anne Marie Healy
Keyword(s):  
Relative Humidity ◽  
Physicochemical Properties ◽  
Solid Dispersion ◽  
Amorphous Solid ◽  
Active Pharmaceutical Ingredient ◽  
Vinyl Pyrrolidone ◽  
Amorphous Solid Dispersion ◽  
Vinyl Polymers ◽  
Solid State Stability

When developing an amorphous solid dispersion (ASD), a prudent choice of polymer is critical to several aspects of ASD performance including: processability, solid state stability and dissolution rate. However, there is little guidance available to formulators to aid judicious polymer selection and a “trial and error” approach is often taken. This study aims to facilitate rational polymer selection and formulation design by generating ASDs using a range of poly-vinyl polymers and ketoprofen as a model active pharmaceutical ingredient (API) and evaluating several aspects of their performance. The molecular weight of the polymer and the ratio of vinyl pyrrolidone to vinyl acetate in the polymer were found to influence the relative humidity at which the relative humidity induced glass transition occurred, as well as the extent of ketoprofen supersaturation achieved during dynamic solubility testing. Interestingly, ASD tablets containing polymers with the vinyl pyrrolidone functional group exhibited higher tensile strengths than those without. This points towards the binder functionality of vinyl pyrrolidone. In conclusion, the physicochemical properties of poly-vinyl polymers greatly influence ketoprofen ASD performance and due regard should be paid to these properties in order to develop an ASD with the desired attributes.

Crystallization kinetics and molecular mobility of an amorphous active pharmaceutical ingredient: A case study with Biclotymol

2015 ◽  
Vol 490 (1-2) ◽  
pp. 248-257 ◽  
Author(s):  
Benjamin Schammé ◽  
Nicolas Couvrat ◽  
Pascal Malpeli ◽  
Laurent Delbreilh ◽  
Valérie Dupray ◽  
...  
Keyword(s):  
Crystallization Kinetics ◽  
Molecular Mobility ◽  
Active Pharmaceutical Ingredient
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