Crystal habit modification and polymorphic stability assessment of a long-acting β2-adrenergic agonist

CrystEngComm ◽  
2019 ◽  
Vol 21 (22) ◽  
pp. 3460-3470 ◽  
Author(s):  
Ameessa Tulcidas ◽  
Nuno M. T. Lourenço ◽  
Rafael Antunes ◽  
Bruno Santos ◽  
Sylwin Pawlowski ◽  
...  
Keyword(s):  
Melting Point ◽  
Drug Substance ◽  
Crystal Habit ◽  
Stability Assessment ◽  
Adrenergic Agonist ◽  
Polymorphic Stability ◽  
Long Acting ◽  
Habit Modification

Crystal habit modification of a drug substance by performing a slurry test at a temperature higher than the melting point.

Nanoscale Visualization of Crystal Habit Modification by Atomic Force Microscopy

1997 ◽  
Vol 9 (3) ◽  
pp. 773-783 ◽  
Author(s):  
Guangzhao Mao ◽  
Lloyd Lobo ◽  
Ray Scaringe ◽  
Michael D. Ward
Keyword(s):  
Atomic Force Microscopy ◽  
Crystal Habit ◽  
Force Microscopy ◽  
Atomic Force ◽  
Habit Modification

Polymer Mediated Crystal Habit Modification

1995 ◽  
pp. 63-71 ◽  
Author(s):  
Allen M. Carrier ◽  
Michael L. Standish
Keyword(s):  
Crystal Habit ◽  
Habit Modification

scholarly journals DEVELOPMENT AND EVALUATION OF CIPROFLOXACIN HYDROCHLORIDE LOADED OCULAR INSERT BY USING “PLANTAGO OVATA” AS NATURAL POLYMER

2018 ◽  
Vol 10 (4) ◽  
pp. 79
Author(s):  
Ayushi Chourasia ◽  
Shikha Agrawal
Keyword(s):  
Melting Point ◽  
Drug Release ◽  
Release Profile ◽  
Natural Polymer ◽  
Plantago Ovata ◽  
In Vitro Drug Release ◽  
Ciprofloxacin Hydrochloride ◽  
Long Acting ◽  
Ocular Insert

Objective: The present work focus in the direction of “Development and evaluation of Ciprofloxacin Hydrochloride loaded ocular insert by using “plantago ovata” as natural polymer”. The current work was carried out to evaluate the control release profile of ocular insert. Natural polymer in ocular insert was used for studying the long acting property. Natural polymer is also used to enhance the bioavailability of drug and reduce toxicity. It is also used to increase the duration of action of drug for prolongs action and gives better in vitro performance as compare than to the conventional ocular formulation.Methods: Solvent casting method was used in the formulation of Ciprofloxacin Hydrochloride loaded ocular inserts. Different ocular insert formulations of varying polymer concentration were prepared. Ocular insert formulation H-1 to H-3 was prepared by using different concentration of HPMC and formulation P-1 to P-4 was prepared by using different concentration of Plantago Ovata.Results: The ocular inserts formulation was within the acceptable limits. All the pre formulation parameters of polymers such as derived properties, compressibility index, Hausner’s ratio, viscosity, melting point, swelling ratio, loss on drying, PH of mucilage solution and pre formulation of active pharmaceutical ingredient such as estimation of drug by using UV spectroscopy, determination of melting point, solubility, partition coefficient and FTIR for compatibility study of drug and excipient were evaluation. FTIR analysis also confirmed no drug-excipient interaction.Conclusion: Prepared inserts in the present study were semitransparent. The mixing of the drug in to the polymer is uniform, due to this; the drug content of all formulation is good. Formulation P4 was selected because it showed better release profile, drug content and other physicochemical properties than other formulated batch when compare. All the prepared inserts showed in vitro drug release for the period of 4 h as compare to the marketed formulation. An in vitro drug release study revealed that ocular formulation gives a prolong action. The formulation was found to be long acting.

Crystal Habit Modification of Agel by Impurities Determining the Solvation

1973 ◽  
Vol 21 (1) ◽  
pp. 39-50 ◽  
Author(s):  
F.H. Claes ◽  
J. Libeer ◽  
W. Vanassche
Keyword(s):  
Crystal Habit ◽  
Habit Modification
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