Fluorescence resonance energy transfer (FRET)-based nanoarchitecture for monitoring deubiquitinating enzyme activity

2020 ◽  
Vol 56 (21) ◽  
pp. 3183-3186 ◽  
Author(s):  
Yan-Yan Liang ◽  
Jie Zhang ◽  
Hui Cui ◽  
Zhen-Shu Shao ◽  
Chen Cheng ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Energy Transfer ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Fluorescence Resonance Energy Transfer ◽  
Rhodamine B ◽  
Mesoporous Silica Nanoparticles ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
Deubiquitinating Enzyme

A novel nanoarchitecture (MSN-Tb-UbR) was prepared by modifying rhodamine B-labelled Ubs (Ub-Rs) on the surface of mesoporous silica nanoparticles (MSNs) loaded with Tb3+-complexes.

Real-time imaging of intracellular drug release from mesoporous silica nanoparticles based on fluorescence resonance energy transfer

2014 ◽  
Vol 2 (27) ◽  
pp. 4379-4386 ◽  
Author(s):  
Jun Wang ◽  
Peng Pei Gao ◽  
Xiao Xi Yang ◽  
Ting Ting Wang ◽  
Jian Wang ◽  
...  
Keyword(s):  
Energy Transfer ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Real Time ◽  
Fluorescence Resonance Energy Transfer ◽  
Mesoporous Silica Nanoparticles ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
Fluorescence Resonance

A multifunctional nanodevice is designed based on doxorubicin (DOX)-loaded green fluorescent mesoporous silica nanoparticles (FMSN) conjugated with folic acid (FA). Real-time monitoring of intracellular drug release based on fluorescence resonance energy transfer is achieved.

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