A novel distyryl boron dipyrromethene with two functional tags for site-specific bioorthogonal photosensitisation towards targeted photodynamic therapy

2019 ◽  
Vol 55 (90) ◽  
pp. 13518-13521 ◽  
Author(s):  
Xuejiao Guo ◽  
Roy C. H. Wong ◽  
Yimin Zhou ◽  
Dennis K. P. Ng ◽  
Pui-Chi Lo
Keyword(s):  
Photodynamic Therapy ◽  
Targeted Delivery ◽  
Site Specific ◽  
Boron Dipyrromethene ◽  
Targeted Photodynamic Therapy

A sequential “tag-and-click” process for targeted delivery of photosensitisers for photodynamic therapy.

A bioorthogonally activatable photosensitiser for site-specific photodynamic therapy

2020 ◽  
Vol 56 (7) ◽  
pp. 1078-1081 ◽  
Author(s):  
Yimin Zhou ◽  
Roy C. H. Wong ◽  
Gaole Dai ◽  
Dennis K. P. Ng
Keyword(s):  
Photodynamic Therapy ◽  
Alder Reaction ◽  
Diels Alder ◽  
Site Specific ◽  
Inverse Electron Demand ◽  
Diels Alder Reaction ◽  
Boron Dipyrromethene ◽  
Electron Demand

Inverse-electron-demand Diels–Alder reaction of a 1,2,4,5-tetrazine-substituted boron dipyrromethene with a biotin-conjugated trans-cyclooctene results in site-specific activation of the photoactivity of the former photosensitiser.

Ruthenium(II) Conjugates of Boron-Dipyrromethene and Biotin for Targeted Photodynamic Therapy in Red Light

2019 ◽  
Vol 59 (1) ◽  
pp. 913-924
Author(s):  
Subhadeep Paul ◽  
Paramita Kundu ◽  
Utso Bhattacharyya ◽  
Aditya Garai ◽  
Ram Chandra Maji ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Red Light ◽  
Boron Dipyrromethene ◽  
Targeted Photodynamic Therapy

scholarly journals Diplatinum(II) Catecholate of Photoactive Boron-Dipyrromethene for Lysosome-Targeted Photodynamic Therapy in Red Light

2019 ◽  
Vol 58 (14) ◽  
pp. 9067-9075 ◽  
Author(s):  
Vanitha Ramu ◽  
Srishti Gautam ◽  
Paturu Kondaiah ◽  
Akhil R. Chakravarty
Keyword(s):  
Photodynamic Therapy ◽  
Red Light ◽  
Boron Dipyrromethene ◽  
Targeted Photodynamic Therapy

scholarly journals Pyriplatin-Boron-Dipyrromethene Conjugates for Imaging and Mitochondria-Targeted Photodynamic Therapy

2018 ◽  
Vol 57 (22) ◽  
pp. 14374-14385 ◽  
Author(s):  
Md Kausar Raza ◽  
Srishti Gautam ◽  
Prodip Howlader ◽  
Arnab Bhattacharyya ◽  
Paturu Kondaiah ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Boron Dipyrromethene ◽  
Targeted Photodynamic Therapy

One-pot peptide cyclisation and surface modification of photosensitiser-loaded red blood cells for targeted photodynamic therapy

2021 ◽  
Author(s):  
Jacky Chu ◽  
Chihao Shao ◽  
Summer Y. Y. Ha ◽  
Wing-Ping Fong ◽  
Clarence Tsun Ting Wong ◽  
...  
Keyword(s):  
Surface Modification ◽  
Photodynamic Therapy ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Tumour Targeting ◽  
One Pot ◽  
Boron Dipyrromethene ◽  
Targeting Peptide ◽  
Targeted Photodynamic Therapy

We report herein a one-pot approach to cyclise a tumour-targeting peptide and conjugate it on the surface of red blood cells loaded with a boron dipyrromethene-based photosensitiser using a bifunctional...

scholarly journals Dual function of lectins — new perspectives in targeted photodynamic therapy

2019 ◽  
Vol 23 (11n12) ◽  
pp. 1241-1250 ◽  
Author(s):  
Vanya Bogoeva ◽  
Lidiya Petrova ◽  
Julie Bouckaert ◽  
Anna Yordanova ◽  
Ivan Ivanov ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Targeted Delivery ◽  
Dual Function ◽  
Tumor Tissues ◽  
Potential Applications ◽  
Specific Antigens ◽  
Imaging Detection ◽  
New Perspective ◽  
Targeted Photodynamic Therapy

Porphyrins and phthalocyanines are photosensitizers (PS) that are used in clinical imaging, detection of cancer cells and are particularly applied in photodynamic therapy (PDT). Many scientists have been focused on the design of different porphyrin compounds. However, similar to other anti-cancer agents, they cannot selectively recognize tumor tissues. Scientists are seeking new methods to overcome this problem and to find appropriate targeted delivery strategies. Plant lectins are especially suitable molecules for such targeting as they preferentially recognize specific antigens on the glycosylated cancer cells. This review will give more detailed information about the dual function of lectins and their interactions with PSs, which is a new perspective in targeted PDT. The implications and potential applications of such studies will also be discussed.

scholarly journals A Hypericin Delivery System Based on Polydopamine Coated Cerium Oxide Nanorods for Targeted Photodynamic Therapy

Polymers ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 1025 ◽  
Author(s):  
Yang Wang ◽  
Yu Zhang ◽  
Ming Jin ◽  
Yinghua Lv ◽  
Zhichao Pei ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cerium Oxide ◽  
Delivery System ◽  
Targeted Delivery ◽  
Oxide Nanorods ◽  
Alkaline Conditions ◽  
Targeting Ability ◽  
Human Hepatoma Hepg2 Cells ◽  
Will Self ◽  
Targeted Photodynamic Therapy

Photodynamic therapy (PDT) as a non-aggressive therapy with fewer side effects has unique advantages over traditional treatments. However, PDT still has certain limitations in clinical applications, mainly because most photosensitizers utilized in PDT are hydrophobic compounds, which will self-aggregate in the aqueous phase and cause undesirable effects. In order to resolve this, we utilized the self-polymerization of dopamine molecules under alkaline conditions to coat cerium oxide nanorods (CeONR) with a dense polydopamine (PDA) film. Thereafter, thiolated galactose (Gal-SH) and hypericin (Hyp) were modified and loaded onto the surface to construct CeONR@PDA-Gal/Hyp, respectively, which can be used for targeted photodynamic therapy of human hepatoma HepG2 cells. CeONR@PDA-Gal/Hyp was characterized by transmission electron microscope (TEM), Zeta potential, Ultraviolet-visible (UV-Vis), and fluorescence spectroscopy, respectively. This hypericin delivery system possesses good biocompatibility and specific targeting ability, where the galactose units on the surface of CeONR@PDA-Gal/Hyp can specifically recognize the asialo-glycoprotein receptors (ASGP-R), which overexpress on HepG2 cell membrane. Furthermore, Hyp will detach from the surface of CeONR@PDA-Gal/Hyp after the nanorods enter cancer cells, and shows excellent PDT effect under the irradiation of light with a wavelength of 590 nm. Our work exemplifies a novel targeted delivery of hydrophobic photosensitizers for cancer treatment.

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