EDA complex directed N-centred radical generation from nitrosoarenes: a divergent synthetic approach

2019 ◽  
Vol 55 (90) ◽  
pp. 13590-13593 ◽  
Author(s):  
Soumen Ghosh ◽  
Gautam Kumar ◽  
Naveen Naveen ◽  
Suman Pradhan ◽  
Indranil Chatterjee
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Synthetic Approach ◽  
Radical Generation ◽  
Eda Complex

N-Centred radicals generated via the formation of EDA complexes are added to electron-deficient allylsulfones to produce isoxazolidines, aziridines or β-amino acid derivatives.

Preparation of enantiopure long chain threo-2-amino-3-hydroxyesters via chiral morpholinone-derived azomethine ylids

2006 ◽  
Vol 84 (10) ◽  
pp. 1448-1455 ◽  
Author(s):  
Victoria A Brome ◽  
Laurence M Harwood ◽  
Helen MI Osborn
Keyword(s):  
Amino Acid ◽  
Building Blocks ◽  
Dipolar Cycloaddition ◽  
Amino Acid Derivatives ◽  
Synthetic Approach ◽  
Alkyl Chains ◽  
Long Chain

The synthetic approach to threo-2-amino-3-hydroxyesters possessing long alkyl chains outlined herein centres on the generation of chiral azomethine ylids by reaction of (5R)-5-phenyl-morpholin-2-one, (R)-(1), with long chain aldehydes. In the presence of a second equivalent of aldehyde, the azomethine ylid can be trapped to afford a cycloadduct with three new stereodefined centres. Degradation of the cycloadduct allows entry to β-substituted-α-amino acid derivatives, which have potential as building blocks for sphingosine synthesis.Key words: sphingosine, morpholinone, chiral azomethine ylid, dipolar cycloaddition.

ChemInform Abstract: α-FUNCTIONALIZED AMINO ACID DERIVATIVES. A SYNTHETIC APPROACH OF POSSIBLE BIOGENETIC IMPORTANCE

1980 ◽  
Vol 11 (44) ◽  
Author(s):  
J. D. M. HERSCHEID ◽  
R. J. F. NIVARD ◽  
M. W. TIJHUIS ◽  
H. P. H. SCHOLTEN ◽  
H. C. J. OTTENHEIJM
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Synthetic Approach

.alpha.-Functionalized amino acid derivatives. A synthetic approach of possible biogenetic importance

1980 ◽  
Vol 45 (10) ◽  
pp. 1880-1885 ◽  
Author(s):  
Jacobus D. M. Herscheid ◽  
Rutger J. F. Nivard ◽  
Marian W. Tijhuis ◽  
Henk P. H. Scholten ◽  
Harry C. J. Ottenheijm
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Synthetic Approach

Three Amino Acid Derivatives of Valproic Acid: Design, Synthesis, Theoretical and Experimental Evaluation as Anticancer Agents

2014 ◽  
Vol 14 (7) ◽  
pp. 984-993 ◽  
Author(s):  
Gabriela Luna-Palencia ◽  
Federico Martinez-Ramos ◽  
Ismael Vasquez-Moctezuma ◽  
Manuel Fragoso-Vazquez ◽  
Jessica Mendieta-Wejebe ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Amino Acid ◽  
Anticancer Agents ◽  
Experimental Evaluation ◽  
Amino Acid Derivatives ◽  
Design Synthesis ◽  
Derivatives Of

scholarly journals In vitro anticancer potentiality and molecular modelling study of novel amino acid derivatives based on N1,N3-bis-(1-hydrazinyl-1-oxopropan-2-yl) isophthalamide

2019 ◽  
Vol 34 (1) ◽  
pp. 1247-1258 ◽  
Author(s):  
Asmaa F. Kassem ◽  
Gaber O. Moustafa ◽  
Eman S. Nossier ◽  
Hemat S. Khalaf ◽  
Marwa M. Mounier ◽  
...  
Keyword(s):  
Amino Acid ◽  
Molecular Modelling ◽  
Amino Acid Derivatives ◽  
Modelling Study

scholarly journals Synthesis and antimicrobial activity of some novel 1,2-dihydro-[1,2,4]triazolo[1,5-a]pyrimidines bearing amino acid moiety

RSC Advances ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 2905-2916
Author(s):  
Mounir A. A. Mohamed ◽  
Adnan A. Bekhit ◽  
Omyma A. Abd Allah ◽  
Asmaa M. Kadry ◽  
Tamer M. Ibrahim ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Amino Acid ◽  
Green Chemistry ◽  
Antimicrobial Activities ◽  
Amino Acid Derivatives ◽  
Acid Moiety ◽  
Amino Acid Moiety

A new series of [1,2,4]-triazole bearing amino acid derivatives were synthesized under green chemistry conditions and evaluated for their antimicrobial activities.

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