scholarly journals Quinoxaline derivatives disrupt the base stacking of hepatitis C virus-internal ribosome entry site RNA: reduce translation and replication

2019 ◽  
Vol 55 (93) ◽  
pp. 14027-14030 ◽  
Author(s):  
Jeet Chakraborty ◽  
Ajay Kanungo ◽  
Tridib Mahata ◽  
Krishna Kumar ◽  
Geetika Sharma ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Small Molecule ◽  
Internal Ribosome Entry Site ◽  
Base Stacking ◽  
Entry Site ◽  
Internal Ribosome Entry ◽  
Quinoxaline Derivatives ◽  
Translational Inhibition ◽  
Virus Internal Ribosome Entry

Targeting the bend architecture: base de-stacking of the bend right-angled architecture of subdomain IIa leads to translational inhibition by a quinoxaline small molecule.

The Hepatitis C Virus Internal Ribosome Entry Site Adopts an Ion-dependent Tertiary Fold

1999 ◽  
Vol 292 (3) ◽  
pp. 513-529 ◽  
Author(s):  
Jeffrey S. Kieft ◽  
Kaihong Zhou ◽  
Ronald Jubin ◽  
Michael G. Murray ◽  
Johnson Y.N. Lau ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Internal Ribosome Entry Site ◽  
Entry Site ◽  
Internal Ribosome Entry ◽  
Virus Internal Ribosome Entry

scholarly journals 2-Aminobenzoxazole ligands of the hepatitis C virus internal ribosome entry site

2014 ◽  
Vol 24 (15) ◽  
pp. 3521-3525 ◽  
Author(s):  
Kevin D. Rynearson ◽  
Brian Charrette ◽  
Christopher Gabriel ◽  
Jesus Moreno ◽  
Mark A. Boerneke ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Internal Ribosome Entry Site ◽  
Entry Site ◽  
Internal Ribosome Entry ◽  
Virus Internal Ribosome Entry
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