Two-dimensional supramolecular assemblies based on β-cyclodextrin-grafted graphene oxide for mitochondrial dysfunction and photothermal therapy

2019 ◽  
Vol 55 (81) ◽  
pp. 12200-12203 ◽  
Author(s):  
Bing Zhang ◽  
Qilin Yu ◽  
Ying-Ming Zhang ◽  
Yu Liu
Keyword(s):  
Graphene Oxide ◽  
Tumor Growth ◽  
Mitochondrial Dysfunction ◽  
Tumor Cells ◽  
Mitochondrial Function ◽  
Photothermal Therapy ◽  
Supramolecular Assemblies ◽  
Two Dimensional ◽  
Inhibition Of Tumor Growth

A 2D supramolecular nanoassemblies specifically target the mitochondria of tumor cells and severely disrupt mitochondrial function in a photocontrollable manner, leading to remarkable inhibition of tumor growth.

A polyprodrug-based nanoplatform for cisplatin prodrug delivery and combination cancer therapy

2019 ◽  
Vol 55 (93) ◽  
pp. 13987-13990 ◽  
Author(s):  
Chunhao Lin ◽  
Yiran Tao ◽  
Phei Er Saw ◽  
Minghui Cao ◽  
Hai Huang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Tumor Growth ◽  
Tumor Cells ◽  
Combination Cancer Therapy ◽  
Inhibition Of Tumor Growth

A robust mitoxantrone (MTO)-based polyprodrug nanoplatform was herein developed for systemic cisplatin prodrug delivery. This nanoplatform can concurrently deliver MTO and cisplatin to tumor cells and shows combinational inhibition of tumor growth.

Aptamer-modified CuS nanocrystals/graphene oxide composites for controlled release of glucosamine and chemo-photothermal therapy of tumor cells

2017 ◽  
Vol 195 ◽  
pp. 131-135 ◽  
Author(s):  
Ziqing Xu ◽  
Shicheng Wu ◽  
Guicheng Huang ◽  
Hongwei Ding ◽  
Rijun Gui ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Controlled Release ◽  
Tumor Cells ◽  
Photothermal Therapy ◽  
Oxide Composites

Post-synthesis strategy to integrate porphyrinic metal–organic frameworks with CuS NPs for synergistic enhanced photo-therapy

2020 ◽  
Vol 8 (5) ◽  
pp. 935-944 ◽  
Author(s):  
Xiaochun Hu ◽  
Yonglin Lu ◽  
Lulu Zhou ◽  
Lv Chen ◽  
Tianming Yao ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Photothermal Therapy ◽  
Metal Organic Frameworks ◽  
Synthesis Strategy ◽  
Metal Organic ◽  
Inhibition Of Tumor Growth ◽  
Post Synthesis

A multi-functional nanoplatform (PCN-CuS-FA-ICG) for combined photodynamic and photothermal therapy was presented, which demonstrated good inhibition of tumor growth.

Melatonin modifies tumor hypoxia and metabolism by inhibiting HIF-1α and energy metabolic pathway in the in vitro and in vivo models of breast cancer

2019 ◽  
Vol 2 (4) ◽  
pp. 83-98 ◽  
Author(s):  
André De Lima Mota ◽  
Bruna Vitorasso Jardim-Perassi ◽  
Tialfi Bergamin De Castro ◽  
Jucimara Colombo ◽  
Nathália Martins Sonehara ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Glucose Metabolism ◽  
Tumor Growth ◽  
Tumor Cells ◽  
Carbonic Anhydrases ◽  
In Vivo Models ◽  
Ca Ix ◽  
Gene And Protein Expression

Breast cancer is the most common cancer among women and has a high mortality rate. Adverse conditions in the tumor microenvironment, such as hypoxia and acidosis, may exert selective pressure on the tumor, selecting subpopulations of tumor cells with advantages for survival in this environment. In this context, therapeutic agents that can modify these conditions, and consequently the intratumoral heterogeneity need to be explored. Melatonin, in addition to its physiological effects, exhibits important anti-tumor actions which may associate with modification of hypoxia and Warburg effect. In this study, we have evaluated the action of melatonin on tumor growth and tumor metabolism by different markers of hypoxia and glucose metabolism (HIF-1α, glucose transporters GLUT1 and GLUT3 and carbonic anhydrases CA-IX and CA-XII) in triple negative breast cancer model. In an in vitro study, gene and protein expressions of these markers were evaluated by quantitative real-time PCR and immunocytochemistry, respectively. The effects of melatonin were also tested in a MDA-MB-231 xenograft animal model. Results showed that melatonin treatment reduced the viability of MDA-MB-231 cells and tumor growth in Balb/c nude mice (p <0.05). The treatment significantly decreased HIF-1α gene and protein expression concomitantly with the expression of GLUT1, GLUT3, CA-IX and CA-XII (p <0.05). These results strongly suggest that melatonin down-regulates HIF-1α expression and regulates glucose metabolism in breast tumor cells, therefore, controlling hypoxia and tumor progression. 

ANTITUMOR EFFECT OF COLLOIDAL SILVER BISILICATE IN EXPERIMENTAL IN VITRO AND IN VIVO STUDIES

2019 ◽  
Vol 65 (5) ◽  
pp. 760-765
Author(s):  
Margarita Tyndyk ◽  
Irina Popovich ◽  
A. Malek ◽  
R. Samsonov ◽  
N. Germanov ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Tumor Growth ◽  
Tumor Cells ◽  
Human Tumor ◽  
Significant Inhibition ◽  
In Vivo Studies ◽  
Ehrlich Carcinoma ◽  
In Vivo Experiments

The paper presents the results of the research on the antitumor activity of a new drug - atomic clusters of silver (ACS), the colloidal solution of nanostructured silver bisilicate Ag6Si2O7 with particles size of 1-2 nm in deionized water. In vitro studies to evaluate the effect of various ACS concentrations in human tumor cells cultures (breast cancer, colon carcinoma and prostate cancer) were conducted. The highest antitumor activity of ACS was observed in dilutions from 2.7 mg/l to 5.1 mg/l, resulting in the death of tumor cells in all studied cell cultures. In vivo experiments on transplanted Ehrlich carcinoma model in mice consuming 0.75 mg/kg ACS with drinking water revealed significant inhibition of tumor growth since the 14th day of experiment (maximally by 52% on the 28th day, p < 0.05) in comparison with control. Subcutaneous injections of 2.5 mg/kg ACS inhibited Ehrlich's tumor growth on the 7th and 10th days of the experiment (p < 0.05) as compared to control.

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