Development of a unique reversible fluorescent probe for tracking endogenous sulfur dioxide and formaldehyde fluctuation in vivo

2019 ◽  
Vol 55 (75) ◽  
pp. 11263-11266 ◽  
Author(s):  
Yanyan Ma ◽  
Wenjie Gao ◽  
Linlin Zhu ◽  
Yuping Zhao ◽  
Weiying Lin
Keyword(s):  
Sulfur Dioxide ◽  
Fluorescent Probe

A FRET-based reversible fluorescent probe for sensing SO2 and FA was designed. The probe was first used for imaging endogenous SO2 and FA in vitro and in vivo. Moreover, we first found that the interaction of SO2 and FA can reduce the cytotoxicity.

A novel colorimetric and near-infrared fluorescent probe for hydrogen peroxide imaging in vitro and in vivo

RSC Advances ◽  
2015 ◽  
Vol 5 (104) ◽  
pp. 85957-85963 ◽  
Author(s):  
Peng Wang ◽  
Ke Wang ◽  
Dan Chen ◽  
Yibo Mao ◽  
Yueqing Gu
Keyword(s):  
Hydrogen Peroxide ◽  
Fluorescent Probe ◽  
Near Infrared

A novel NIR fluorescent probe (DCM-B2) based on dicyanomethylene-4H-pyran was synthesized for the detection of H2O2.

A thiazolo[4,5-b]pyridine-based fluorescent probe for detection of zinc ions and application for in vitro and in vivo bioimaging

Talanta ◽  
2018 ◽  
Vol 185 ◽  
pp. 396-404 ◽  
Author(s):  
Jiao Gong ◽  
Yuan-heng Li ◽  
Chan-juan Zhang ◽  
Jian Huang ◽  
Qi Sun
Keyword(s):  
Fluorescent Probe ◽  
Zinc Ions

The development of a hemicyanine-based ratiometric CO fluorescent probe with a long emission wavelength and its applications for imaging CO in vitro and in vivo

2020 ◽  
Vol 44 (28) ◽  
pp. 12107-12112 ◽  
Author(s):  
Yunyan Zhang ◽  
Xiuqi Kong ◽  
Yonghe Tang ◽  
Min Li ◽  
Yaguang Yin ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Living Cells ◽  
Emission Wavelength ◽  
Long Wavelength ◽  
Wavelength Emission ◽  
Ratiometric Fluorescent Probe

A novel ratiometric fluorescent probe, Hcy-CO, with long-wavelength emission was developed for visualizing CO in living cells and zebrafish.

Highly sensitive and selective light-up fluorescent probe for monitoring gallium and chromium ions in vitro and in vivo

The Analyst ◽  
2019 ◽  
Vol 144 (12) ◽  
pp. 3807-3816 ◽  
Author(s):  
Xiaojun He ◽  
Chenglin Wu ◽  
Yuna Qian ◽  
Yahui Li ◽  
Lilei Zhang ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Chromium Ions ◽  
Highly Sensitive ◽  
Bio Imaging

Here reported an NBDT sensor could be effectively responsive to gallium and chromium for bio-imaging in vivo.

1,6-Elimination reaction induced detection of fluoride ions in vitro and in vivo based on a NIR fluorescent probe

2019 ◽  
Vol 220 ◽  
pp. 117108 ◽  
Author(s):  
Aiqing Feng ◽  
Yongmei Jia ◽  
Liping Huang ◽  
Lin Wang ◽  
Guohua Zhou ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Elimination Reaction ◽  
Fluoride Ions

scholarly journals Cancer-Specific Biomarker hNQO1-Activatable Fluorescent Probe for Imaging Cancer Cells In Vitro and In Vivo

Cancers ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 470 ◽  
Author(s):  
Surendra Punganuru ◽  
Hanumantha Madala ◽  
Viswanath Arutla ◽  
Kalkunte Srivenugopal
Keyword(s):  
Cancer Cells ◽  
Fluorescent Probe ◽  
Stokes Shift ◽  
High Sensitivity ◽  
Cell Permeability ◽  
Quinone Oxidoreductase ◽  
Brain Tumor Cells ◽  
Sensitivity And Selectivity

Human NAD(P)H quinone oxidoreductase-1 (hNQO1) is an important cancer-related biomarker, which shows significant overexpression in malignant cells. Developing an effective method for detecting NQO1 activity with high sensitivity and selectivity in tumors holds a great potential for cancer diagnosis, treatment, and management. In the present study, we report a new dicyanoisophorone (DCP) based fluorescent probe (NQ-DCP) capable of monitoring hNQO1 activity in vitro and in vivo in both ratiometric and turn-on model. NQ-DCP was prepared by conjugating dicyanoisophorone fluoroprobe with hNQO1 activatable quinone propionic acid (QPA), which remain non-fluorescent until activation by tumor-specific hNQO1. NQ-DCP featured a large Stokes shift (145 nm), excellent biocompatibility, cell permeability, and selectivity towards hNQO1 allowed to differentiate cancer cells from healthy cells. We have successfully employed NQ-DCP to monitor non-invasive endogenous hNQO1 activity in brain tumor cells in vitro and in xenografted tumors developed in nude mice.

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