A nanoparticle enabled focused ultrasound-stimulated magnetic resonance imaging spotlight

2019 ◽  
Vol 55 (69) ◽  
pp. 10261-10264 ◽  
Author(s):  
Tian Deng ◽  
Le Zhang ◽  
Holden H. Wu ◽  
Jeffrey I. Zink
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
High Intensity ◽  
Focused Ultrasound ◽  
Focal Point ◽  
Region Of Interest ◽  
High Intensity Focused Ultrasound ◽  
Resonance Imaging ◽  
Ultrasound Modulation

Periodic high-intensity focused ultrasound modulation of a nanoparticle generates reversible MRI T1 relaxivity changes at the 1.5 mm3 focal point. A modulation enhancement map spotlights the region of interest by increasing contrast almost 100-fold.

Magnetic Resonance Imaging–guided High-intensity Focused Ultrasound Applications in Pediatrics

2018 ◽  
Vol 27 (1) ◽  
pp. 45-51 ◽  
Author(s):  
Karun V. Sharma ◽  
Pavel S. Yarmolenko ◽  
Avinash Eranki ◽  
Ari Partanen ◽  
Haydar Celik ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Resonance Imaging ◽  
Ultrasound Applications

Magnetic resonance imaging of high-intensity focused ultrasound-stimulated drug release from a self-reporting core@shell nanoparticle platform

2020 ◽  
Vol 56 (71) ◽  
pp. 10297-10300
Author(s):  
Chi-An Cheng ◽  
Wei Chen ◽  
Le Zhang ◽  
Holden H. Wu ◽  
Jeffrey I. Zink
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Drug Release ◽  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Core Shell ◽  
Resonance Imaging

A self-reporting theranostic approach that controls and “images” drug release from nanoparticles using magnetic resonance imaging-guided high-intensity focused ultrasound is presented.

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