A flexible and multifunctional metal–organic framework as a matrix for analysis of small molecules using laser desorption/ionization mass spectrometry

2019 ◽  
Vol 55 (48) ◽  
pp. 6898-6901 ◽  
Author(s):  
Wen Ma ◽  
Shuting Xu ◽  
Wanpeng Ai ◽  
Cheng Lin ◽  
Yu Bai ◽  
...  
Keyword(s):  
Small Molecules ◽  
Metal Organic Framework ◽  
Laser Desorption ◽  
Ionization Mass ◽  
Laser Desorption Ionization ◽  
Desorption Ionization ◽  
Fast Screening ◽  
Metal Organic ◽  
Simultaneous Enrichment ◽  
Saldi Ms

Fast screening of multi-functional MOFs as SALDI-MS matrices for the detection of small molecules and simultaneous enrichment and detection of analytes.

scholarly journals High-Performance Sample Substrate of Gold Nanoparticle Multilayers for Surface-Assisted Laser Desorption/Ionization Mass Spectrometry

Nanomaterials ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. 1078 ◽  
Author(s):  
Liu ◽  
Chang ◽  
Lin ◽  
Liou ◽  
Kuo
Keyword(s):  
Mass Spectrometry ◽  
Small Molecules ◽  
Mass Spectra ◽  
Laser Desorption ◽  
Ionization Mass ◽  
Laser Desorption Ionization ◽  
Homogeneous Sample ◽  
Desorption Ionization ◽  
Saldi Ms

The development of a sample substrate with superior performance for desorption and ionization of analyte is the key issue to ameliorate the quality of mass spectra for measurements of small molecules in surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS). Herein, the homogeneous sample substrate of gold nanoparticle multilayers (AuNPs-ML) with hexagonal lattice was successfully prepared by self-assembly technique. With strong surface plasmon resonance absorption and superior photothermal effect, the sample substrate of AuNPs-ML exhibited high signal sensitivity and low background noise for the detection of model analyte of glucose without additional matrixes in SALDI-MS. Furthermore, compared to merchant matrixes of α-cyano-4-hydroxycinnamic acid (CHCA) and 2,5-dihydroxybenzoic acid (DHB), the sample substrate of AuNPs-ML was demonstrated to ameliorate the quality of mass spectra, including signal strength, background interference and signal/noise (S/N) ratio. The sucrose and tryptophan were also measured to show the extensive applications of AuNPs-ML sample substrate for the detections of small molecules in SALDI-MS. Most importantly, the remarkable reproducibility of glucose mass spectra with relative signal of 7.3% was obtained by the use of AuNPs-ML sample substrate for SALDI-MS. The homogeneous sample substrate of AuNPs-ML greatly improved the quality of mass spectra because of its strong absorption of laser energy, low specific heat, high heat conductivity and extraordinary homogeneity. We believe that AuNPs-ML could be a practical sample substrate for small molecule detection in SALDI-MS.

Metal–organic frameworks: new matrices for surface-assisted laser desorption–ionization mass spectrometry

2013 ◽  
Vol 49 (43) ◽  
pp. 4929 ◽  
Author(s):  
Yung-Han Shih ◽  
Ching-Hsuan Chien ◽  
Brenda Singco ◽  
Chang-Lin Hsu ◽  
Chia-Her Lin ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Metal Organic Frameworks ◽  
Laser Desorption ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Laser Desorption Ionization ◽  
Desorption Ionization ◽  
Metal Organic
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