Anti-inflammatory marine cyclic peptide stylissatin A and its derivatives inhibit differentiation of murine preadipocytes

2019 ◽  
Vol 55 (38) ◽  
pp. 5471-5474 ◽  
Author(s):  
Menghua Zhang ◽  
Taiki Sunaba ◽  
Yiting Sun ◽  
Kazunori Sasaki ◽  
Hiroko Isoda ◽  
...  
Keyword(s):  
Cyclic Peptide ◽  
Triglyceride Accumulation ◽  
Cyclic Heptapeptide ◽  
Anti Inflammatory ◽  
Murine Preadipocytes

Stylissatin A, an anti-inflammatory cyclic heptapeptide, and its derivatives inhibited the differentiation of preadipocytes and the triglyceride accumulation in adipocytes.

Anti-inflammatory activity of a new cyclic peptide, citrusin XI, isolated from the fruits of Citrus unshiu

2015 ◽  
Vol 163 ◽  
pp. 106-112 ◽  
Author(s):  
Hyung Jun Noh ◽  
Dukhyun Hwang ◽  
Eun Suk Lee ◽  
Jae Wook Hyun ◽  
Pyoung Ho Yi ◽  
...  
Keyword(s):  
Cyclic Peptide ◽  
Inflammatory Activity ◽  
Citrus Unshiu ◽  
Anti Inflammatory

Unguisin F, a new cyclic peptide from the endophytic fungus Mucor irregularis

2016 ◽  
Vol 71 (1-2) ◽  
pp. 15-19 ◽  
Author(s):  
Sergi H. Akone ◽  
Georgios Daletos ◽  
Wenhan Lin ◽  
Peter Proksch
Keyword(s):  
Endophytic Fungus ◽  
Cyclic Peptide ◽  
High Resolution Mass Spectrometry ◽  
Two Dimensional ◽  
Amino Acid Residues ◽  
Moringa Stenopetala ◽  
Mucor Irregularis ◽  
Antifungal Potential ◽  
Cyclic Heptapeptide ◽  
Antibacterial And Antifungal

Abstract The new cyclic heptapeptide unguisin F (1) and the known congener unguisin E (2), were obtained from the endophytic fungus Mucor irregularis, isolated from the medicinal plant Moringa stenopetala, collected in Cameroon. The structure of the new compound was unambiguously determined on the basis of one- and two-dimensional NMR spectroscopy as well as by high-resolution mass spectrometry. The absolute configuration of the amino acid residues of 1 and 2 was determined using Marfey’s analysis. Compounds 1 and 2 were evaluated for their antibacterial and antifungal potential, but failed to display significant activities.

scholarly journals PO-459 Systemic anti-inflammatory effect of a new anticancer cyclic peptide ALOS4

2018 ◽  
Author(s):  
E Nesher ◽  
A Pinhasov ◽  
M Becker ◽  
R Cohen-Harazi ◽  
S Yakobovich ◽  
...  
Keyword(s):  
Cyclic Peptide ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Recyclable hypervalent-iodine-mediated solid-phase peptide synthesis and cyclic peptide synthesis

2018 ◽  
Vol 14 ◽  
pp. 1112-1119 ◽  
Author(s):  
Dan Liu ◽  
Ya-Li Guo ◽  
Jin Qu ◽  
Chi Zhang
Keyword(s):  
Peptide Synthesis ◽  
Cyclic Peptide ◽  
Solid Phase ◽  
Biological Activities ◽  
Solid Phase Peptide Synthesis ◽  
Coupling Reaction ◽  
Hypervalent Iodine ◽  
Peptide Coupling ◽  
Cyclic Peptide Synthesis ◽  
Cyclic Heptapeptide

The system of the hypervalent iodine(III) reagent FPID and (4-MeOC6H4)3P was successfully applied to solid-phase peptide synthesis and cyclic peptide synthesis. Four peptides with biological activities were synthesized through SPPS and the bioactive cyclic heptapeptide pseudostellarin D was obtained via solution-phase peptide synthesis. It is worth noting that FPID can be readily regenerated after the peptide coupling reaction.

scholarly journals Cyclic peptide unguisin A is an anion receptor with high affinity for phosphate and pyrophosphate

2017 ◽  
Vol 15 (14) ◽  
pp. 2962-2967 ◽  
Author(s):  
A. Daryl Ariawan ◽  
James E. A. Webb ◽  
Ethan N. W. Howe ◽  
Philip A. Gale ◽  
Pall Thordarson ◽  
...  
Keyword(s):  
Binding Affinity ◽  
Cyclic Peptide ◽  
Anion Receptor ◽  
High Affinity ◽  
High Binding ◽  
Cyclic Heptapeptide ◽  
High Binding Affinity

Unguisin A (1) is a marine-derived, GABA-containing cyclic heptapeptide with a high binding affinity for phosphates.

Acyl-CoA dehydrogenase long chain (ACADL) is a target protein of stylissatin A, an anti-inflammatory cyclic heptapeptide

2020 ◽  
Vol 73 (8) ◽  
pp. 589-592
Author(s):  
Menghua Zhang ◽  
Taiki Sunaba ◽  
Yiting Sun ◽  
Takahiro Shibata ◽  
Kazunori Sasaki ◽  
...  
Keyword(s):  
Target Protein ◽  
Cyclic Heptapeptide ◽  
Anti Inflammatory ◽  
Long Chain

Studies of Australian Ascidians. IV. Mollamide, a Cytotoxic Cyclic Heptapeptide From the Compound Ascidian Didemnum molle

1994 ◽  
Vol 47 (1) ◽  
pp. 61 ◽  
Author(s):  
AR Carroll ◽  
BF Bowden ◽  
JC Coll ◽  
DCR Hockless ◽  
BW Skelton ◽  
...  
Keyword(s):  
Amino Acids ◽  
Cyclic Peptide ◽  
Peptide Hydrolysis ◽  
One Dimensional ◽  
Crystallographic Study ◽  
Relative Stereochemistry ◽  
Cyclic Heptapeptide ◽  
Hydrolysis Of ◽  
Absolute Stereochemistry

A new cytotoxic cyclic heptapeptide, mollamide, has been isolated from the compound ascidian Didemnum molle. The structure of mollamide was initially deduced from one-dimensional and two-dimensional n.m.r . experiments at 300 MHz. The structure was confirmed by an X-ray crystallographic study, which showed the relative stereochemistry of the cyclic peptide. Hydrolysis of mollamide , and characterization of the amino acids by derivatization with Nα -(5-fluoro-2,4-dinitrophenyl)-L- alaninamide (FDAA; Marfey's reagent) gave the absolute stereochemistry; all constituent amino acids were the L-isomers. Cytotoxicity data are reported.

scholarly journals Anti-inflammatory activity of c(ILDV-NH(CH2 )5 CO), a novel, selective, cyclic peptide inhibitor of VLA-4-mediated cell adhesion

1999 ◽  
Vol 126 (8) ◽  
pp. 1751-1760 ◽  
Author(s):  
Duncan Haworth ◽  
Amanda Rees ◽  
Peter J Alcock ◽  
Linda J Wood ◽  
Anand S Dutta ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Cyclic Peptide ◽  
Inflammatory Activity ◽  
Peptide Inhibitor ◽  
Anti Inflammatory

scholarly journals Phytochemical Analysis, Anti-inflammatory, and Antioxidant Activities of Dendropanax dentiger Roots

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Li Yang ◽  
Yiwei Fang ◽  
Ronghua Liu ◽  
Junwei He
Keyword(s):  
High Performance ◽  
Cyclic Peptide ◽  
Antioxidant Activities ◽  
Inflammatory Diseases ◽  
Phytochemical Analysis ◽  
Chemical Compositions ◽  
Biological Functions ◽  
Cox 2 ◽  
Anti Inflammatory

Dendropanax dentiger root is a traditional medicinal plant in China and used to treat inflammatory diseases for centuries, but its phytochemical profiling and biological functions are still unknown. Thus, a rapid, efficient, and precise method based on ultra high-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (UHPLC-Q-TOF-MS/MS) was applied to rapidly analyse the phytochemical profiling of D. dentiger with anti-inflammatory and antioxidant activities in vitro. As a result, a total of 78 chemical compositions, including 15 phenylpropanoids, 15 alkaloids, 14 flavonoids, 14 fatty acids, 7 phenols, 4 steroids, 4 cyclic peptides, 3 terpenoids, and 2 others, were identified or tentatively characterized in the roots of D. dentiger. Moreover, alkaloid and cyclic peptide were reported from D. dentiger for the first time. In addition, the ethanol crude extract of D. dentiger roots exhibited remarkable anti-inflammatory activity against cyclooxygenase- (COX-) 2 inhibitory and antioxidant activities in vitro. This study is the first to explore the phytochemical analysis and COX-2 inhibitory activity of D. dentiger. This study can provide important phytochemical profiles and biological functions for the application of D. dentiger roots as a new source of natural COX-2 inhibitors and antioxidants in pharmaceutical industry.

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