Intelligent polymer–MnO2 nanoparticles for dual-activatable photoacoustic and magnetic resonance bimodal imaging in living mice

2019 ◽  
Vol 55 (43) ◽  
pp. 6006-6009 ◽  
Author(s):  
Xiaoming Hu ◽  
Chen Zhan ◽  
Yufu Tang ◽  
Feng Lu ◽  
Yuanyuan Li ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Bimodal Imaging ◽  
Mno2 Nanoparticles ◽  
Intelligent Polymer

We herein report intelligent polymer–MnO2 nanoparticles for dual-activatable photoacoustic and magnetic resonance bimodal imaging in living mice.

scholarly journals Design and Synthesis of Luminescent Lanthanide-Based Bimodal Nanoprobes for Dual Magnetic Resonance (MR) and Optical Imaging

Nanomaterials ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 354
Author(s):  
Walid Mnasri ◽  
Mahsa Parvizian ◽  
Souad Ammar-Merah
Keyword(s):  
Magnetic Resonance ◽  
Optical Imaging ◽  
Imaging Technique ◽  
Imaging Techniques ◽  
Design And Synthesis ◽  
Bimodal Imaging ◽  
Successive Image ◽  
Complete Set ◽  
Magnetic Resonance Imaging Mri ◽  
Physical And Chemical

Current biomedical imaging techniques are crucial for the diagnosis of various diseases. Each imaging technique uses specific probes that, although each one has its own merits, do not encompass all the functionalities required for comprehensive imaging (sensitivity, non-invasiveness, etc.). Bimodal imaging methods are therefore rapidly becoming an important topic in advanced healthcare. This bimodality can be achieved by successive image acquisitions involving different and independent probes, one for each mode, with the risk of artifacts. It can be also achieved simultaneously by using a single probe combining a complete set of physical and chemical characteristics, in order to record complementary views of the same biological object at the same time. In this scenario, and focusing on bimodal magnetic resonance imaging (MRI) and optical imaging (OI), probes can be engineered by the attachment, more or less covalently, of a contrast agent (CA) to an organic or inorganic dye, or by designing single objects containing both the optical emitter and MRI-active dipole. If in the first type of system, there is frequent concern that at some point the dye may dissociate from the magnetic dipole, it may not in the second type. This review aims to present a summary of current activity relating to this kind of dual probes, with a special emphasis on lanthanide-based luminescent nano-objects.

Targeted gold nanoshelled hybrid nanocapsules encapsulating doxorubicin for bimodal imaging and near-infrared triggered synergistic therapy of Her2-positve breast cancer

2020 ◽  
Vol 35 (3) ◽  
pp. 430-445
Author(s):  
Qi Dong ◽  
Caifeng Wan ◽  
Hong Yang ◽  
Dongdong Zheng ◽  
Li Xu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Near Infrared ◽  
Average Diameter ◽  
Infrared Light ◽  
Resonance Imaging ◽  
Her2 Positive ◽  
Bimodal Imaging

A multifunctional targeted nanoplatform combining photothermal therapy and chemotherapy has emerged as a promising strategy for comprehensive therapies of breast cancer. In this study, we constructed human epidermal growth factor receptor 2 (Her2)-targeted gold nanoshelled poly(lactic- co-glycolic acid) hybrid nanocapsules encapsulating perfluorooctyl bromide, superparamagnetic iron oxide nanoparticles, and doxorubicin (Her2-GPDH nanocapsules) as theranostic agent for bimodal ultrasound/magnetic resonance imaging and synergistic photothermal-chemotherapy of Her2-postive breast cancer cells. Her2–GPDH nanocomposites possessed well-defined spherical morphology, and the average diameter was about 296 nm with good dispersion. Targeting assays demonstrated that Her2–GPDH nanocapsules exhibited higher targeting binding to Her2-positive SKBR3 cells than Her2-negative MDA-MB-231cells. The encapsulation efficiency and the loading content of doxorubicin in Her2–GPDH nanocapsules were 39 ± 1.45% and 3.8 ± 0.52%, respectively, and the agent exhibited pH-responsive and near-infrared light-triggered stepwise release behavior of doxorubicin. In vitro, the agent had potential to serve as feasible candidate for ultrasound imaging and T2-weighted magnetic resonance imaging with a relatively high relaxivity. Cell experiments confirmed that the agent had significant photothermal cytotoxicity on SKBR3 cells, and the combined photothermal–chemotherapy could significantly enhance the anti-tumor effect. In summary, the present Her2–GPDH nanocapsules, a novel multifunctional nanoplatform, will offer a new way for early bimodal molecular-level diagnosis and synergistic treatment of Her2-positve breast cancer.

scholarly journals Stable confinement of positron emission tomography and magnetic resonance agents within carbon nanotubes for bimodal imaging

Nanomedicine ◽  
2014 ◽  
Vol 9 (16) ◽  
pp. 2499-2509 ◽  
Author(s):  
Brandon T Cisneros ◽  
Justin J Law ◽  
Michael L Matson ◽  
Ali Azhdarinia ◽  
Eva M Sevick-Muraca ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Positron Emission Tomography ◽  
Magnetic Resonance ◽  
Emission Tomography ◽  
Bimodal Imaging ◽  
Positron Emission

Multifunctional silica-coated iron oxide nanoparticles: a facile four-in-one system for in situ study of neural stem cell harvesting

2014 ◽  
Vol 175 ◽  
pp. 13-26 ◽  
Author(s):  
Yung-Kang Peng ◽  
Cathy N. P. Lui ◽  
Tsen-Hsuan Lin ◽  
Chen Chang ◽  
Pi-Tai Chou ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Neural Stem Cells ◽  
Neural Stem Cell ◽  
Cell Therapies ◽  
Bimodal Imaging

Neural stem cells (NSCs), which generate the main phenotypes of the nervous system, are multipotent cells and are able to differentiate into multiple cell types via external stimuli from the environment. The extraction, modification and re-application of NSCs have thus attracted much attention and raised hopes for novel neural stem cell therapies and regenerative medicine. However, few studies have successfully identified the distribution of NSCs in a live brain and monitored the corresponding extraction processes both in vitro and in vivo. To address those difficulties, in this study multi-functional uniform nanoparticles comprising an iron oxide core and a functionalized silica shell (Fe3O4@SiO2(FITC)-CD133, FITC: a green emissive dye, CD133: anti-CD133 antibody) have been strategically designed and synthesized for use as probe nanocomposites that provide four-in-one functionality, i.e., magnetic agitation, dual imaging (both magnetic resonance and optical) and specific targeting. It is shown that these newly synthesized Fe3O4@SiO2(FITC)-CD133 particles have clearly demonstrated their versatility in various applications. (1) The magnetic core enables magnetic cell collection and T2 magnetic resonance imaging. (2) The fluorescent FITC embedded in the silica framework enables optical imaging. (3) CD133 anchored on the outermost surface is demonstrated to be capable of targeting neural stem cells for cell collection and bimodal imaging.

In situ synthesis of fluorescent polydopamine on biogenic MnO2 nanoparticles as stimuli responsive multifunctional theranostics

2021 ◽  
Author(s):  
Jin Liu ◽  
Meizhou Zhang ◽  
Yuzhou Wu
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Manganese Dioxide ◽  
Clinical Applications ◽  
In Situ Synthesis ◽  
Stimuli Responsive ◽  
Resonance Imaging ◽  
Mno2 Nanoparticles ◽  
Multifunctional Nanocomposites

Multifunctional nanocomposites have drawn great attention in clinical applications because of their ability to integrate diagnostic and therapeutic functions. Manganese dioxide (MnO2), owing to its biocompatibility and magnetic resonance imaging...

β-conjugation of gadolinium(III) DOTA complexes to zinc(II) porpholactol as potential multimodal imaging contrast agents

2014 ◽  
Vol 18 (10n11) ◽  
pp. 950-959 ◽  
Author(s):  
Xian-Sheng Ke ◽  
Juan Tang ◽  
Zi-Shu Yang ◽  
Jun-Long Zhang
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Aqueous Media ◽  
Resonance Imaging ◽  
Bimodal Imaging ◽  
Imaging Experiment ◽  
Meso Position ◽  
Magnetic Resonance Imaging Mri ◽  
Magnetic Resonance Imaging Experiment

Synthesis of two bimodal imaging agents consist of a hydrophobic zinc(II) tetrapentafluorophenylporpholactol core and a β-substituted hydrophilic Gd ( III ) DO3A (ZnLGd539) or DOTA (ZnLGd595) like moiety has been described (DO3A = 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid, DOTA = 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid). Through β-conjugation approach, the absorption at deep red region increases compared to traditional conjugation methods at meso-position. More importantly, these new complexes possess largely improved ionic relaxitivites relative to the sole Gd ( III ) magnetic resonance imaging (MRI) agents such as Gd ( III ) DO3A and Gd ( III ) DOTA like complexes. Combining the optical and magnetic resonance measurements in aqueous media, the largely enhanced r1 relaxivities was attributed to the aggregation of ZnLGd539 and ZnLGd595 in aqueous media. Furthermore, fluorescence and magnetic resonance imaging experiment showed that both ZnLGd539 and ZnLGd595 can be applied as potential bimodal imaging contrast agents. Finally, both compounds showed no dark cytotoxicity and good photocytotoxicity (IC50 = 1.73 ± 0.13 and 1.52 ± 0.10 μM for ZnLGd539 and ZnLGd595 respectively) on Hela cells.

Enzymatically synthesised MnO2 nanoparticles for efficient near-infrared photothermal therapy and dual-responsive magnetic resonance imaging

Nanoscale ◽  
2021 ◽  
Author(s):  
Jin Liu ◽  
Liandong Feng ◽  
Yuzhou Wu
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Biomedical Applications ◽  
Near Infrared ◽  
Tumour Microenvironment ◽  
Stimuli Responsive ◽  
Resonance Imaging ◽  
Dual Responsive ◽  
Mno2 Nanoparticles ◽  
Magnetic Resonance Imaging Mri

Manganese dioxide (MnO2) nanoparticles (NPs) are highly attractive for biomedical applications due to their biocompatibility, stimuli-responsive magnetic resonance imaging (MRI) properties and capability to modulate the hypoxic tumour microenvironment (TME)....

Gd3+-Functionalized gold nanoclusters for fluorescence–magnetic resonance bimodal imaging

2017 ◽  
Vol 5 (10) ◽  
pp. 2122-2130 ◽  
Author(s):  
Guohai Liang ◽  
Lifu Xiao
Keyword(s):  
Magnetic Resonance ◽  
Mr Imaging ◽  
Gold Nanoclusters ◽  
Bimodal Imaging ◽  
High Relaxivity

Gd3+-Functionalized gold nanoclusters with high relaxivity and excellent biocompatibility are synthesized for optical and MR imaging.

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