Organocatalytic enantioselective direct alkylation of phloroglucinol derivatives: asymmetric total synthesis of (+)-aflatoxin B2

2019 ◽  
Vol 55 (35) ◽  
pp. 5171-5174 ◽  
Author(s):  
Zhonglei Wang ◽  
Liansuo Zu
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Asymmetric Total Synthesis ◽  
Phloroglucinol Derivatives ◽  
Chiral Centers ◽  
Aflatoxin B2

The organocatalytic enantioselective Friedel–Crafts alkylation of the phloroglucinol derivatives with enals is reported, providing general access to the benzylic chiral centers shown in a variety of phloroglucinol natural products.

Asymmetric Total Synthesis of 16-Methyleicos-(4E )-en-1-yn-3-ol from the Marine Sponge Cribrochalina vasculum : Establishment of Absolute Configuration of Chiral Centers

2019 ◽  
Vol 4 (1) ◽  
pp. 399-402 ◽  
Author(s):  
Narayana Rao Gundoju ◽  
Ramesh Bokam ◽  
Nageswara Rao Yalavarthi ◽  
Karimulla Shaik ◽  
Mangala Gowri Ponnapalli
Keyword(s):  
Total Synthesis ◽  
Absolute Configuration ◽  
Marine Sponge ◽  
Asymmetric Total Synthesis ◽  
Chiral Centers

Recent results toward the stereoselective synthesis of biologically active natural products

2007 ◽  
Vol 79 (2) ◽  
pp. 163-172 ◽  
Author(s):  
Luiz C. Dias ◽  
Luciana G. de Oliveira ◽  
Paulo R. R. Meira
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Cell Cultures ◽  
Stereoselective Synthesis ◽  
Animal Cell ◽  
Biologically Active ◽  
Asymmetric Total Synthesis ◽  
Callystatin A ◽  
Animal Cell Cultures ◽  
Active Natural

This paper describes the convergent and stereocontrolled asymmetric total synthesis of (+)-crocacins C and D, potent inhibitors of animal cell cultures and several yeasts and fungi, and (-)-callystatin A, a potent antitumor polyketide.

Diversity-Oriented Synthesis of Natural Products via Gold-Catalyzed Cascade Reactions

Synlett ◽  
2018 ◽  
Vol 29 (12) ◽  
pp. 1552-1571 ◽  
Author(s):  
Jianxian Gong ◽  
Zhen Yang ◽  
Yueqing Gu ◽  
Ceheng Tan
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Cascade Reactions ◽  
Cascade Reaction ◽  
Biologically Active ◽  
Synthetic Methods ◽  
Left Wing ◽  
Asymmetric Total Synthesis ◽  
Diversity Oriented Synthesis ◽  
Active Natural

This account describes our group’s latest research in the field of diversity-oriented synthesis of natural products via gold-catalyzed cascade reactions. We present two general strategies based on gold-catalyzed cycloisomerization: a gold-catalyzed cascade reaction of 1,7-diynes and a pinacol-terminated gold-catalyzed cascade reaction. We highlight our development of synthetic methods for the construction of biologically active natural products by using these two strategies.1 Introduction2 Gold-Catalyzed Cascade Reactions of 1,7-Diynes2.1 Collective Synthesis of C15 Oxygenated Drimane-Type Sesquiterpenoids2.2 Synthesis of Left-Wing Fragment of Azadirachtin I2.3 Collective Synthesis of Cladiellins3 Pinacol-Terminated Gold-Catalyzed Cascade Reaction3.1 Asymmetric Formal Total Synthesis of (+)-Cortistatins3.2 Total Synthesis of Orientalol F3.3 Asymmetric Total Synthesis of (–)-Farnesiferol C4 Summary and Outlook

Asymmetric Total Synthesis of Complex Marine Natural Products

ChemInform ◽  
2006 ◽  
Vol 37 (26) ◽  
Author(s):  
Jorma Hassfeld ◽  
Markus Kalesse ◽  
Timo Stellfeld ◽  
Mathias Christmann
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Marine Natural Products ◽  
Asymmetric Total Synthesis

Facile formation of tetrahydrofurans with multiple chiral centers using double iodoetherification of σ-symmetric diene acetals: short asymmetric total synthesis of rubrenolide and rubrynolide

Tetrahedron ◽  
2008 ◽  
Vol 64 (19) ◽  
pp. 4233-4245 ◽  
Author(s):  
Hiromichi Fujioka ◽  
Yusuke Ohba ◽  
Hideki Hirose ◽  
Kenji Nakahara ◽  
Kenichi Murai ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Asymmetric Total Synthesis ◽  
Chiral Centers
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