Size-controlled synthesis of polymerized DNA nanoparticles for targeted anticancer drug delivery

2019 ◽  
Vol 55 (34) ◽  
pp. 4905-4908 ◽  
Author(s):  
Keonwook Nam ◽  
Taehyung Kim ◽  
Young Min Kim ◽  
Kyungjik Yang ◽  
Deokyoung Choe ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Rolling Circle Amplification ◽  
Controlled Synthesis ◽  
Layer By Layer ◽  
Rolling Circle ◽  
Anticancer Drug Delivery ◽  
Dna Nanoparticles ◽  
Targeted Drug ◽  
Size Controlled

The size-tunable polymerized DNA nanoparticles (PDNs) for cancer-targeted drug delivery were synthesized via sequential processes of rolling circle amplification, condensation, and layer-by-layer assembly.

scholarly journals Designer DNA–silica/carbon nanotube nanocomposites for traceable and targeted drug delivery

2020 ◽  
Vol 8 (11) ◽  
pp. 2250-2255 ◽  
Author(s):  
Yong Hu ◽  
Christof M. Niemeyer
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Carbon Nanotube ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Targeted Drug Delivery ◽  
Rolling Circle Amplification ◽  
Functionalized Carbon Nanotubes ◽  
Rolling Circle ◽  
Targeted Drug

A programmable drug delivery system can be synthesized in a highly modular fashion from DNA-functionalized carbon nanotubes and silica nanoparticles via enzymatic rolling circle amplification.

Synthesis of polymeric micelles with dual-functional sheddable PEG stealth for enhanced tumor-targeted drug delivery

2020 ◽  
Vol 11 (27) ◽  
pp. 4469-4476 ◽  
Author(s):  
Lu Sun ◽  
Hua Wei ◽  
Xianshuo Zhang ◽  
Chao Meng ◽  
Guiying Kang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Targeted Drug Delivery ◽  
Polymeric Micelles ◽  
Anticancer Drug Delivery ◽  
Dual Functional ◽  
Targeted Drug

We reported the synthesis of polymeric micelles with a dual-functional sheddable mPEG stealth to realize simultaneously tumor-triggered targeting and intracellular micelle destabilization for enhanced anticancer drug delivery.

cRGDyK-modified camretastain A4-loaded graphene oxide nanosheets for targeted anticancer drug delivery

RSC Advances ◽  
2015 ◽  
Vol 5 (50) ◽  
pp. 40258-40268 ◽  
Author(s):  
Jing Wang ◽  
Qingqing Tian ◽  
Fang Ding ◽  
Yanyan Yu ◽  
Fanhong Wu
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Anticancer Drug ◽  
Targeted Drug Delivery ◽  
Integrin Expression ◽  
Functionalized Graphene ◽  
Graphene Oxide Nanosheets ◽  
Functionalized Graphene Oxide ◽  
Anticancer Drug Delivery ◽  
Targeted Drug

Functionalized graphene oxide (CGO–cRGDyK/POLO) nanosheets were designed and developed for targeted drug delivery to integrin expression.

scholarly journals Hydrolysable core crosslinked particles for receptor-mediated pH-sensitive anticancer drug delivery

2015 ◽  
Vol 39 (11) ◽  
pp. 8840-8847 ◽  
Author(s):  
Xifeng Liu ◽  
A. Lee Miller II ◽  
Brian E. Waletzki ◽  
Tewodros K. Mamo ◽  
Michael J. Yaszemski ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Targeted Drug Delivery ◽  
Ph Sensitive ◽  
Anticancer Drug Delivery ◽  
Targeted Drug

An extracellular stable micelle with a folate conjugated surface, a crosslinked core and pH-sensitive hydrolysable bonds was developed for cancer targeted drug delivery.

scholarly journals Shaping Rolling Circle Amplification Products into DNA Nanoparticles by Incorporation of Modified Nucleotides and Their Application to In Vitro and In Vivo Delivery of a Photosensitizer

Molecules ◽  
2018 ◽  
Vol 23 (7) ◽  
pp. 1833 ◽  
Author(s):  
Kyoung-Ran Kim ◽  
Pascal Röthlisberger ◽  
Seong Kang ◽  
Kihwan Nam ◽  
Sangyoup Lee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cellular Uptake ◽  
Rolling Circle Amplification ◽  
Modified Nucleotides ◽  
Rolling Circle ◽  
Dna Nanoparticles ◽  
Nuclease Resistance ◽  
Cellular Uptake Efficiency

Rolling circle amplification (RCA) is a robust way to generate DNA constructs, which are promising materials for biomedical applications including drug delivery because of their high biocompatibility. To be employed as a drug delivery platform, however, the DNA materials produced by RCA need to be shaped into nanoparticles that display both high cellular uptake efficiency and nuclease resistance. Here, we showed that the DNA nanoparticles (DNPs) can be prepared with RCA and modified nucleotides that have side-chains appended on the nucleobase are capable of interacting with the DNA strands of the resulting RCA products. The incorporation of the modified nucleotides improved cellular uptake efficiency and nuclease resistance of the DNPs. We also demonstrated that these DNPs could be employed as carriers for the delivery of a photosensitizer into cancer cells to achieve photodynamic therapy upon irradiation at both the in vitro and in vivo levels.

Multifunctional sharp pH-responsive nanoparticles for targeted drug delivery and effective breast cancer therapy

2019 ◽  
Vol 7 (4) ◽  
pp. 576-585 ◽  
Author(s):  
Yandan Yao ◽  
Phei Er Saw ◽  
Yan Nie ◽  
Ping-Pui Wong ◽  
Linjia Jiang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Anticancer Drug ◽  
Targeted Drug Delivery ◽  
Ph Responsive ◽  
Breast Cancer Therapy ◽  
Anticancer Drug Delivery ◽  
Targeted Drug

A new multifunctional pH-responsive NP platform was developed for targeted anticancer drug delivery and effective breast cancer therapy.

scholarly journals Conjugation of a smart polymer to doxorubicin through a pH-responsive bond for targeted drug delivery and improving drug loading on graphene oxide

RSC Advances ◽  
2021 ◽  
Vol 11 (31) ◽  
pp. 18809-18817
Author(s):  
Ali Bina ◽  
Heidar Raissi ◽  
Hassan Hashemzadeh ◽  
Farzaneh Farzad
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Anticancer Drug ◽  
Targeted Drug Delivery ◽  
Polymeric Nanoparticles ◽  
Drug Loading ◽  
Ph Responsive ◽  
Smart Polymer ◽  
Anticancer Drug Delivery ◽  
Targeted Drug

Polymeric nanoparticles have emerged as efficient carriers for anticancer drug delivery because they can improve the solubility of hydrophobic drugs and also can increase the bio-distribution of drugs throughout the bloodstream.

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